95975-55-6
95975-55-6 结构式
基本信息
咕咕草
香胶甾酮
CIS-4,17(20)-PREGNADIENE-3,16-DIONE
CIS GUGGULSTERONE
GUGGULESTERONE Z
GUGGULSTERONE
GUGGULSTERONE Z
GUGGULSTERONE (Z FORM)
GUGULSTERONE
PREGNA-4,17(20)-DIENE-3,16-DIONE
(Z)-GUGGULSTERONE
(8S,9R,10R,13S,14S,17E)-17-(1-methoxyethylidene)-10,13-dimethyl-1,2,6,7,8,9,11,12,14,15-decahydrocyclopenta[a]phenanthrene-3,16-dione
pregna-4,17-diene-3,16-dione
GUGGULISTERONES 95%
(17Z)-Pregna-4,17(20)-diene-3,16-dione
(Z)-Guggulsterone
物理化学性质
常见问题列表
香胶甾酮是一种植物甾醇，来自 Commiphora wightii 树的树胶脂。 香胶甾酮通过下调抗细胞凋亡 (apoptosis) 基因产物 (IAP1，xIAP，Bfl-1/A1，Bcl-2，cFLIP，survivin)，调节细胞周期蛋白 (cyclin D1，c-Myc)，激活 caspases，JNK，抑制 Akt，抑制多种肿瘤细胞的生长并诱导细胞凋亡。香胶甾酮通过调节几种转录因子介导基因表达，包括 NF-κB，STAT3，C /EBPα，雄激素受体 (androgen receptor) 和糖皮质激素受体(glucocorticoid receptors)。它是一种法尼醇 X 受体 (FXR) 拮抗剂，可降低 CDCA 诱导的 FXR 活化，Z- 和 E-Guggulsterone 的 IC50 分别为 17 和 15 μM。
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JNK
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Akt
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Caspase
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Guggulsterone (0.5-20 μM; 24 hours) suppresses TREM-1, TLR4 and TNF-α expression as well as the phosphorylation of IκBα and NF-κB p65 by LPS.
Western Blot Analysis
| Cell Line: | RAW 264.7 murine macrophage cells |
| Concentration: | 0.5, 5, 10, 20 μM |
| Incubation Time: | 24 hours |
| Result: | Suppressed TREM-1, TLR4, and TNF-α expression as well as the phosphorylation of IκBα and NF-κB p65 by LPS. |
Guggulsterone (orally; 100 mg/kg once per day for 8 days) significantly improved the survival rates of wild-type mice with TNBS-induced colitis.
| Animal Model: | Wild-type mice with TNBS-induced colitis |
| Dosage: | 100 mg/kg |
| Administration: | Orally; once per day; for 8 days |
| Result: | Improved the survival rates of wild-type mice with TNBS-induced colitis. |