GW1929
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- CAS号:
- 196808-24-9
- 英文名:
- GW1929
- 英文别名:
- GW1929;GW1929 HYDRATE;GW 1929 hydrochlorid;GW 1929 hydrochloride;GW1929 - CAS 196808-24-9 - Calbiochem;N-(2-BENZOYLPHENYL)-O-[2-(METHYL-2-PYRIDINYLAMINO)ETHYL]-L-TYROSINE;L-Tyrosine, N-(2-benzoylphenyl)-O-[2-(methyl-2-pyridinylamino)ethyl]-;N-(2-Benzoylphenyl)-O-[2-(methyl-2-pyridinylamino)ethyl]-L-tyrosine hydrate;N-(2-Benzoylphenyl)-O-[2-(methyl-2-pyridinylamino)ethyl]-L-tyrosinehydrochloride;(2S)-2-(2-benzoylanilino)-3-[4-[2-[methyl(pyridin-2-yl)amino]ethoxy]phenyl]propanoic acid
- 中文名:
- GW1929
- 中文别名:
- GW1929 CALBIOCHEM;N-(2-苯甲酰基苯基)-O-[2-(甲基-2-吡啶基氨基)乙基]-L-酪氨酸
- CBNumber:
- CB0259985
- 分子式:
- C30H29N3O4
- 分子量:
- 495.57
- MOL File:
- 196808-24-9.mol
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GW1929化学性质
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沸点:
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749.2±60.0 °C(Predicted)
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密度:
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1.264±0.06 g/cm3(Predicted)
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储存条件:
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Desiccate at +4°C
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溶解度:
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DMSO: 20 mg/mL
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形态:
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solid
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酸度系数(pKa):
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3.91±0.10(Predicted)
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颜色:
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yellow
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InChIKey:
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QTQMRBZOBKYXCG-MHZLTWQESA-N
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GW1929性质、用途与生产工艺
GW1929是有效的 PPAR-γ 激动剂，对人 PPAR-γ 的 pKi 为8.84。对人和鼠的 pEC50 分别为8.56 和 8.27。
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PPAR-γ
8.56 (pEC
50
, Human PPAR-γ)
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GW1929 is a potent PPAR-γ activator, with pK
i
s of 8.84, < 5.5, and < 6.5 for human PPAR-γ, PPAR-α, and PPAR-δ, and pEC
50
s of 8.56 and 8.27 for human PPAR-γ and murine PPAR-γ, respectively. GW1929 (10 μM) inhibits TBBPA-induced caspase-3 increase and TBBPA-stimulated LDH release in neocortical cell cultures.
GW1929 (0.5, 1, 5 mg/kg, p.o.) highly decreases nonfasted plasma glucose levels in Zucker diabetic fatty (ZDF) rats after treatment for 14 days, and possesses antilipolytic efficacy. GW1929 (1, 5 mg/kg, p.o.) increases glucose-stimulated insuline secretion of β-cell in ZDF rats.
GW1929
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/04/30 | HY-15655 | N-(2-苯甲酰基苯基)-O-[2-(甲基-2-吡啶基氨基)乙基]-L-酪氨酸
GW1929 | 196808-24-9 | 10mM * 1mLin DMSO | 1045元 |
| 2024/01/25 | HY-15655 | GW1929 | | 1 mg | 431元 |
196808-24-9, GW1929 相关搜索:
- Intracellular receptor
- 原料药
- 小分子
- 细胞周期
- Cell Biology
- Cell Signaling and Neuroscience
- BioChemical
- Gene Regulation and Expression
- PPAR and RXR Regulators
- GW1929 CALBIOCHEM
- N-(2-苯甲酰基苯基)-O-[2-(甲基-2-吡啶基氨基)乙基]-L-酪氨酸
- 196808-24-9
- GW1929 - CAS 196808-24-9 - Calbiochem
- L-Tyrosine, N-(2-benzoylphenyl)-O-[2-(methyl-2-pyridinylamino)ethyl]-
- GW 1929 hydrochlorid
- N-(2-BENZOYLPHENYL)-O-[2-(METHYL-2-PYRIDINYLAMINO)ETHYL]-L-TYROSINE
- N-(2-Benzoylphenyl)-O-[2-(methyl-2-pyridinylamino)ethyl]-L-tyrosinehydrochloride
- GW 1929 hydrochloride
- (S)-2-(2-Benzoylphenylamino)-3-(4-(2-(methyl(pyridin-2-yl)amino)ethoxy)phenyl)propanoic acid
- (2S)-2-(2-benzoylanilino)-3-[4-[2-[methyl(pyridin-2-yl)amino]ethoxy]phenyl]propanoic acid
- N-(2-Benzoylphenyl)-O-[2-(methyl-2-pyridinylamino)ethyl]-L-tyrosine hydrate
- GW1929 HYDRATE
- GW1929