LY310762
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- CAS号:
- 192927-92-7
- 英文名:
- LY310762
- 英文别名:
- CS-195;LY 310762 HCl;LY310762 USP/EP/BP;LY310762;LY-310762;LY-310,762 HYDROCHLORIDE;1-[2-[4-(4-fluorobenzoyl)piperidin-1-yl]ethyl]-3,3-dimethylindol-2-one;1-[2-[4-(4-fluorobenzoyl)piperidin-1-yl]ethyl]-3,3-dimethylindol-2-one,hydrochloride;1-(2-(4-(4-fluorobenzoyl)piperidin-1-yl)ethyl)-3,3-diMethylindolin-2-one Hydrochloride;1-[2-[4-(4-Fluorobenzoyl)-1-piperidinyl]ethyl]-1,3-dihydro-3,3-dimethyl-2H-indol-2-onehydrochloride;3,3-Dimethyl-1-{2-[4-(4-fluorobenzoyl)-1-piperidinyl]-1-ethyl}-1,3-dihydro-2H-indol-2-one hydrochloride
- 中文名:
- LY310762
- 中文别名:
- 化合物LY310762;LY310762,5-HT1拮抗剂;1-(2-(4-(4-氟苯甲酰基)哌啶-1-基)乙基)-3,3-二甲基吲哚啉-2-酮盐酸盐;1-[2-[4-(4-氟苯甲酰基)-1-哌啶基]乙基]-1,3-二氢-3,3-二甲基-2H-吲哚-2-酮盐酸盐
- CBNumber:
- CB0488147
- 分子式:
- C24H27O2N2FHCl
- 分子量:
- 0
- MOL File:
- 192927-92-7.mol
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LY310762化学性质
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储存条件:
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Sealed in dry,Room Temperature
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溶解度:
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DMSO: 10 mg/mL with heating, soluble
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形态:
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white powder
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CAS 数据库:
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192927-92-7
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LY310762性质、用途与生产工艺
LY310762是一种5-HT1D受体拮抗剂，K
i为249 nM，对5-HT1B受体具有较低的亲和力。
LY310762 has a higher affinity for the guinea pig 5-HT1D receptor than for the 5-HT1B receptor. LY310762 potentiates the potassium-induced [
3H]5-HT outflow from guinea pig cortical slices with an EC50 of 30 nM. The maximum potentiation of the potassium-induced outflow which is obtained with LY310762 is about 40%. LY310762 blocks the decreased EPSC amplitude induced by Sumatriptan.
Systemic administration of LY310762 (10 mg/kg i.p.) produces a further significant enhancement in the 5-HT response to fluoxetine (20 mg/kg i.p.) when compared to animals receiving a control vehicle injection. In fluoxetine treated animals, levels of 5-HT increases from 312±43% to a maximum of 683% after LY310762. In control animals, levels of 5-HT remains unchanged (250%). LY310762 administered alone also significantly increases basal levels of 5-HT above vehicle controls, reaching a maximum of 258% compared to the pre-injection control.
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5-HT
1D
Receptor
249 nM (Ki)
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LY310762
上下游产品信息
上游原料
下游产品
192927-92-7, LY310762 相关搜索:
- Inhibitors
- 药靶配体
- 小分子抑制剂
- 神经信号
- 小分子抑制剂，天然产物
- C24H27O2N2FHCl
- C24H28ClFN2O2
- C24H27FN2O2HCl
- LY310762,5-HT1拮抗剂
- 化合物LY310762
- 1-(2-(4-(4-氟苯甲酰基)哌啶-1-基)乙基)-3,3-二甲基吲哚啉-2-酮盐酸盐
- 1-[2-[4-(4-氟苯甲酰基)-1-哌啶基]乙基]-1,3-二氢-3,3-二甲基-2H-吲哚-2-酮盐酸盐
- 192927-92-7
- LY 310762,5-HT Receptor,5-hydroxytryptamine Receptor,Inhibitor,LY-310762,LY310762,Serotonin Receptor,inhibit
- 1-[2-[4-(4-fluorobenzoyl)-1-piperidinyl]ethyl]-1,3-dihydro-3,3-dimethyl-2H-Indol-2-one hydrochloride (1:1)
- 2H-Indol-2-one, 1-[2-[4-(4-fluorobenzoyl)-1-piperidinyl]ethyl]-1,3-dihydro-3,3-dimethyl-, hydrochloride (1:1)
- 1-[2-[4-(4-fluorobenzoyl)piperidin-1-yl]ethyl]-3,3-dimethylindol-2-one
- LY310762 USP/EP/BP
- CS-195
- 1-[2-[4-(4-fluorobenzoyl)piperidin-1-yl]ethyl]-3,3-dimethylindol-2-one,hydrochloride
- LY-310,762 HYDROCHLORIDE
- 3,3-Dimethyl-1-{2-[4-(4-fluorobenzoyl)-1-piperidinyl]-1-ethyl}-1,3-dihydro-2H-indol-2-one hydrochloride
- LY310762;LY-310762
- 2H-Indol-2-one, 1-[2-[4-(4-fluorobenzoyl)-1-piperidinyl]ethyl]-1,3-dihydro-3,3-diMethyl-, Monohydrochloride
- 1-(2-(4-(4-fluorobenzoyl)piperidin-1-yl)ethyl)-3,3-diMethylindolin-2-one Hydrochloride
- LY 310762 HCl
- 1-[2-[4-(4-Fluorobenzoyl)-1-piperidinyl]ethyl]-1,3-dihydro-3,3-dimethyl-2H-indol-2-onehydrochloride