网站主页 >> CAS数据库列表 >> [4-[Bis(4-chlorophenyl)methyl]piperazin-1-yl]-(5-methyl-4-nitro-1,2-oxazol-3-yl)methanone
[4-[Bis(4-chlorophenyl)methyl]piperazin-1-yl]-(5-methyl-4-nitro-1,2-oxazol-3-yl)methanone
|
|
|
- CAS号:
- 1360705-96-9
- 英文名:
- [4-[Bis(4-chlorophenyl)methyl]piperazin-1-yl]-(5-methyl-4-nitro-1,2-oxazol-3-yl)methanone
- 英文别名:
- ML 210;CID 49766530;ML 210 >=98% (HPLC);ML 210 - CID 49766530;[4-[Bis(4-chlorophenyl)methyl]-1-piperazinyl](5-methyl-4-nitro-3-isoxazolyl)methanone;(4-(Bis(4-chlorophenyl)methyl)piperazin-1-yl)(5-methyl-4-nitroisoxazol-3-yl)methanone;Methanone, [4-[bis(4-chlorophenyl)methyl]-1-piperazinyl](5-methyl-4-nitro-3-isoxazolyl)-;[4-[Bis(4-chlorophenyl)methyl]piperazin-1-yl]-(5-methyl-4-nitro-1,2-oxazol-3-yl)methanone;residue,Ferroptosis,inhibit,peroxidase,ML-210,Covalent,selenocysteine,Glutathione Peroxidase,ML 210,ML210,glutathione,Inhibitor,GPX4,anti-cancer
- 中文名:
- [4-[Bis(4-chlorophenyl)methyl]piperazin-1-yl]-(5-methyl-4-nitro-1,2-oxazol-3-yl)methanone
- 中文别名:
- 化合物ML-210;ML 210,杀死突变的表达HRAS的细胞;(4-(双(4-氯苯基)甲基)哌嗪-1-基)(5-甲基-4-硝基异噁唑-3-基)甲酮;(4-(双(4-氯苯基)甲基)哌嗪-1-基)(5-甲基-4-硝基异恶唑-3-基)甲酮
- CBNumber:
- CB12750494
- 分子式:
- C22H20Cl2N4O4
- 分子量:
- 475.32
- MOL File:
- 1360705-96-9.mol
|
|
|
[4-[Bis(4-chlorophenyl)methyl]piperazin-1-yl]-(5-methyl-4-nitro-1,2-oxazol-3-yl)methanone化学性质
-
沸点:
-
644.7±55.0 °C(Predicted)
-
|
-
密度:
-
1.415±0.06 g/cm3(Predicted)
-
|
-
储存条件:
-
2-8°C
-
|
-
溶解度:
-
Soluble in DMSO (up to 30 mg/ml)
-
|
-
酸度系数(pKa):
-
4.69±0.10(Predicted)
-
|
-
形态:
-
powder
-
|
-
颜色:
-
white to beige
-
|
-
稳定性:
-
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
-
|
[4-[Bis(4-chlorophenyl)methyl]piperazin-1-yl]-(5-methyl-4-nitro-1,2-oxazol-3-yl)methanone性质、用途与生产工艺
ML-210 (CID 49766530)是一种选择性的 glutathione peroxidase 4 (GPX4) 的共价抑制剂，其EC50值为0.04 μM，可诱导铁死亡。ML-210 可以选择性地杀死诱导表达突变型 RAS 的细胞，并具有抗癌活性。
| Target | Value |
RAS
()
|
|
GPX4
(Cell-free assay)
|
0.04 μM(EC50)
|
ML-210 exhibits cell-killing activity across a panel of 821 cancer cell lines (WM88, LOX-IMVI, CJM, U257, CAKI2, A498, HT1080, MC38, PANC02). ML-210 is a prodrug that requires cellular activation to bind GPX4.
ML-210 has
IC
50
s of 71 nM, 272 nM and 107nM for BJeLR (HRAS
V12
), BJeH-LT (without HRAS
V12
) and DRD cell lines, respectively.
[4-[Bis(4-chlorophenyl)methyl]piperazin-1-yl]-(5-methyl-4-nitro-1,2-oxazol-3-yl)methanone
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/01/25 | HY-100003 | ML-210 | | 1 mg | 409元 |
| 2024/01/25 | HY-100003 | [4-[Bis(4-chlorophenyl)methyl]piperazin-1-yl]-(5-methyl-4-nitro-1,2-oxazol-3-yl)methanone
ML-210 | 1360705-96-9 | 5mg | 900元 |
[4-[Bis(4-chlorophenyl)methyl]piperazin-1-yl]-(5-methyl-4-nitro-1,2-oxazol-3-yl)methanone
生产厂家
1360705-96-9, [4-[Bis(4-chlorophenyl)methyl]piperazin-1-yl]-(5-methyl-4-nitro-1,2-oxazol-3-yl)methanone 相关搜索:
- 药靶配体
- ML 210,杀死突变的表达HRAS的细胞
- (4-(双(4-氯苯基)甲基)哌嗪-1-基)(5-甲基-4-硝基异噁唑-3-基)甲酮
- 化合物ML-210
- (4-(双(4-氯苯基)甲基)哌嗪-1-基)(5-甲基-4-硝基异恶唑-3-基)甲酮
- 1360705-96-9
- residue,Ferroptosis,inhibit,peroxidase,ML-210,Covalent,selenocysteine,Glutathione Peroxidase,ML 210,ML210,glutathione,Inhibitor,GPX4,anti-cancer
- (4-(Bis(4-chlorophenyl)methyl)piperazin-1-yl)(5-methyl-4-nitroisoxazol-3-yl)methanone
- ML 210 >=98% (HPLC)
- Methanone, [4-[bis(4-chlorophenyl)methyl]-1-piperazinyl](5-methyl-4-nitro-3-isoxazolyl)-
- ML 210 - CID 49766530
- [4-[Bis(4-chlorophenyl)methyl]-1-piperazinyl](5-methyl-4-nitro-3-isoxazolyl)methanone
- ML 210
- CID 49766530
- [4-[Bis(4-chlorophenyl)methyl]piperazin-1-yl]-(5-methyl-4-nitro-1,2-oxazol-3-yl)methanone