ML329
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- CAS号:
- 19992-50-8
- 英文名:
- ML329
- 英文别名:
- ML329;ML329;ML 329;ML-329,ML329,ML 329,Inhibitor,inhibit;4-((1,4-Dioxo-1,4-dihydronaphthalen-2-yl)amino)benzenesulfonamide;Benzenesulfonamide, 4-[(1,4-dihydro-1,4-dioxo-2-naphthalenyl)amino]-
- 中文名:
- ML329
- 中文别名:
- 化合物ML329;4-((1,4-二氧代-1,4-二氢萘-2-基)氨基)苯磺酰胺
- CBNumber:
- CB23171697
- 分子式:
- C16H12N2O4S
- 分子量:
- 328.34
- MOL File:
- 19992-50-8.mol
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ML329化学性质
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储存条件:
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2-8°C(protect from light)
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溶解度:
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DMF: 20 mg/ml; DMSO: 20 mg/ml; DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml; Ethanol: 0.1 mg/ml
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形态:
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A crystalline solid
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ML329性质、用途与生产工艺
ML329 是一种 micropthalmia-associated transcription factor (MITF) 的抑制剂，可抑制 TRPM-1 promoter 的活性，其IC50值为1.2 μM。
| Target | Value |
MITF
()
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TRPM-1 promoter
(Cell-free assay)
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1.2 μM
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ML329 inhibits the expression of numerous micropthalmia-associated transcription factor (MITF) target genes and blocks the proliferation of numerous cell lines that require MITF for proliferation. ML329 could directly or indirectly interact with MITF or components of the MITF regulatory network. As a transcription factor that regulates cell cycle and pigmentation, interference of MITF with ML329 will be useful in characterizing the specific roles of MITF in melanoma and validate blockade of MITF function as a potential treatment of melanoma. ML329 shows specific activity against the MITF-dependent cells, primary melanocytes but no effect on the viability in A375 cells. ML329 reduces the expression of multiple MITF target genes, including pigment-related genes and the cell cycle regulator CDK2. As a tool compound, ML329 will be useful in elucidating the role of MITF in melanocyte lineage development and in melanoma disease progression.
ML329
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下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/04/30 | HY-101464 | ML329 | | 1 mg | 613元 |
| 2024/04/30 | HY-101464 | ML329
ML329 | 19992-50-8 | 5mg | 1350元 |
19992-50-8, ML329 相关搜索:
- 药靶配体
- 化合物ML329
- 4-((1,4-二氧代-1,4-二氢萘-2-基)氨基)苯磺酰胺
- 19992-50-8
- ML-329,ML329,ML 329,Inhibitor,inhibit
- ML329;ML 329
- 4-((1,4-Dioxo-1,4-dihydronaphthalen-2-yl)amino)benzenesulfonamide
- Benzenesulfonamide, 4-[(1,4-dihydro-1,4-dioxo-2-naphthalenyl)amino]-
- ML329