奥西那林
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- CAS号:
- 586-06-1
- 英文名:
- Orciprenaline
- 英文别名:
- orciprenaline;Orciprenaline USP/EP/BP;Epinephrine Impurity 43;Orciprenaline & Orciprenaline Sulfate;Isoprenaline Hydrochloride Impurity 28;Metaproterenol (base and/or unspecified salts);1-(3,5-dihydroxyphenyl)-2-isopropylaminoethanol;5-[1-hydroxy-2-(isopropylamino)ethyl]resorcinol;5-[2-(Isopropylamino)-1-hydroxyethyl]-1,3-benzenediol;3,5-Dihydroxy-a-[(isopropylamino)methyl]benzyl alcohol
- 中文名:
- 奥西那林
- 中文别名:
- 奥西那林;间羟异丙基肾上腺素;化合物 T16043;肾上腺素杂质43盐酸盐;5-(1-羟基-2-异丙基氨基乙基)苯-1,3-二酚
- CBNumber:
- CB1855195
- 分子式:
- C11H17NO3
- 分子量:
- 211.26
- MOL File:
- 586-06-1.mol
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奥西那林化学性质
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熔点:
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100°
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沸点:
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350.94°C (rough estimate)
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密度:
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1.1240 (rough estimate)
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折射率:
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1.5718 (estimate)
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酸度系数(pKa):
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9.11±0.10(Predicted)
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CAS 数据库:
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586-06-1(CAS DataBase Reference)
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奥西那林性质、用途与生产工艺
Metaproterenol (Orciprenaline) 是一种直接作用的拟交感神经药,是 β2-肾上腺素能受体 (β2AR) 激动剂,其 IC50 为 68 nM。Metaproterenol 还具有抗炎活性。
IC50: 68 nM (β2-adrenergic receptor)
Metaproterenol (10 μM; 74 hours; THP-1 cells and bone marrow macrophages) treatment enhances β-arrestin2 and its interaction with IκBα in high glucose-induced THP-1 cells and bone marrow macrophages.
Metaproterenol (10 μM; 74 hours; THP-1 cells and bone marrow macrophages) treatment leads to downregulation of NF-κB in high glucose-induced THP-1 cells and bone marrow macrophages.
Western Blot Analysis
Cell Line:
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THP-1 cells and bone marrow macrophages
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Concentration:
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10 μM
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Incubation Time:
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74 hours
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Result:
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Enhanced β-arrestin2 and its interaction with IκBα.
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RT-PCR
Cell Line:
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THP-1 cells and bone marrow macrophages
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Concentration:
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10 μM
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Incubation Time:
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74 hours
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Result:
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Led to downregulation of NF-κB.
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Treatment of Zucker diabetic fatty rats with Metaproterenol for 12 weeks attenuates monocyte activation as well as pro-inflammatory and pro-fibrotic responses in the kidneys and heart. Thus, Metaproterenol might has protective effects against diabetic renal and cardiovascular complications.
化学性质
熔点100℃。其硫酸([5874-97-5])熔点202-203℃。
用途
支气管扩张药。
生产方法
3,5-二乙酸基乙酰首先与溴反应,然后与异丙胺反应得过且过-(3,5-二羟基苯基)-2-异丙胺乙酮,将其溶于甲醇,在室温下以镍催化氢化,得异丙喘宁。
奥西那林
上下游产品信息
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奥西那林
生产厂家
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奥西那林国内生产厂家
586-06-1, 奥西那林 相关搜索:
- Orciprenaline
- 平喘药物
- 瘦肉精类
- 肾上腺素杂质43盐酸盐
- 化合物 T16043
- 间羟异丙基肾上腺素
- 5-(1-羟基-2-异丙基氨基乙基)苯-1,3-二酚
- 奥西那林
- 586-06-1
- Epinephrine Impurity 43
- Isoprenaline Hydrochloride Impurity 28
- OrciprenalineQ: What is
Orciprenaline Q: What is the CAS Number of
Orciprenaline Q: What is the storage condition of
Orciprenaline Q: What are the applications of
Orciprenaline
- Orciprenaline USP/EP/BP
- Metaproterenol (base and/or unspecified salts)
- Orciprenaline & Orciprenaline Sulfate
- 5-[1-hydroxy-2-(isopropylamino)ethyl]resorcinol
- 5-[2-(Isopropylamino)-1-hydroxyethyl]-1,3-benzenediol
- 3,5-Dihydroxy-α-[(isopropylamino)methyl]benzyl alcohol
- 5-[1-Hydroxy-2-[(1-methylethyl)amino]ethyl]-1,3-benzenediol
- 5-(1-hydroxy-2-((1-methylethyl)amino)ethyl)-3-benzenediol
- 3,5-dihydroxy-alpha-((isopropylamino)methyl)-benzyl alcohol
- 3,5-dihydroxy-alpha-((isopropylamino)methyl)benzyl alcohol
- Benzyl alcohol, 3,5-dihydroxy-a-[(isopropylamino)methyl]- (6CI, 8CI)
- 3,5-Dihydroxy-a-[(isopropylamino)methyl]benzyl alcohol
- 1,3-Benzenediol, 5-[1-hydroxy-2-[(1-methylethyl)amino]ethyl]- (9CI)
- 1,3-Benzenediol, 5-1-hydroxy-2-(1-methylethyl)aminoethyl-
- 1-(3,5-dihydroxyphenyl)-2-isopropylaminoethanol
- orciprenaline
- 5-(1-hydroxy-2-propan-2-ylamino-ethyl)benzene-1,3-diol
- 5-[1-hydroxy-2-(1-methylethylamino)ethyl]benzene-1,3-diol