地塞米松EP杂质E
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- CAS号:
- 13209-41-1
- 英文名:
- Dexamethasone EP Impurity E
- 英文别名:
- VBP15;Dexamethasone EP Imp E;Dexamethasone impurity E;Dexamethasone Impurity L;Carbamazepine Impurity 22;(8S,10S,13S,14S,16R,17R)-17-hydroxy;16α-Methyl-9,11-dehydro Prednisolone;16α-Methyl-9,11-dehydro Prednisolone;Dexamethasone Impurity 5(Dexamethasone EP Impurity E);17,21-dihydroxy-16alpha-methylpregna-1,4,9(11)-triene-3,20-dione
- 中文名:
- 地塞米松EP杂质E
- 中文别名:
- 艾美龙;地塞米松EP杂质E;地塞米松杂质杂质E;糠酸莫米松杂质22;地塞米松磷酸钠杂质E;地塞米松杂质E(EP);地塞米松磷酸钠杂质EP F;地塞米松磷酸钠杂质EP E;16Α-甲基-9,11-脱氢泼尼松龙;地塞米松杂质5(地塞米松EP杂质E)
- CBNumber:
- CB1921384
- 分子式:
- C22H28O4
- 分子量:
- 356.46
- MOL File:
- 13209-41-1.mol
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地塞米松EP杂质E化学性质
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熔点:
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228-231 °C(Solv: acetone (67-64-1); hexane (110-54-3))
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沸点:
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548.3±50.0 °C(Predicted)
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密度:
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1.24±0.1 g/cm3(Predicted)
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储存条件:
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Refrigerator
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溶解度:
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Chloroform (Slightly), Dioxane (Slightly), Ethyl Acetate (Slightly)
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形态:
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Solid
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酸度系数(pKa):
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12.53±0.70(Predicted)
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颜色:
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Pale Yellow
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地塞米松EP杂质E性质、用途与生产工艺
Vamorolone (VBP15) 是首创的,具有口服活性的解离性类固醇 (dissociative steroidal) 抗炎药和膜稳定剂。Vamorolone 改善肌营养不良,无副作用。Vamorolone 抑制 (NF-κB) 抑制作用,并降低了激素的影响。
Vamorolone (VBP15) inhibits TNFα-induced pro-inflammatory NF-κB signaling in C2C12 muscle cells at 1 nM or more. Vamorolone binds the glucocorticoid receptor (GR) and mineralocorticoid receptor (MR) with similar affinity.
Vamorolone (0.1, 1μM; 30 minutes) reduces production of IL1βand CCL5 inflammatory mediators in primary human macrophages.
Vamorolone is a first-in-class mineralocorticoid receptor (MR) antagonist/dissociative glucocorticoid receptor (GR) ligand.
Vamorolone (5-30 mg/kg; cherry syrup) shows a superior side effect profile compared to pharmacological glucocorticoids in
mdx
mice.
Vamorolone (30 mg/kg; orally; daily for 20 days) reduces CNS Inflammation in murine experimental autoimmune encephalomyelitis.
Animal Model:
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C57BL/6 mice (experimental autoimmune encephalomyelitis)
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Dosage:
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30 mg/kg
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Administration:
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Orally; daily for 20 days (starting one day prior to MOG 33-55 peptide immunization and continuing)
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Result:
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Reduced CNS inflammation in murine experimental autoimmune encephalomyelitis.
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地塞米松EP杂质E
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13209-41-1, 地塞米松EP杂质E 相关搜索:
- Steroids
- Pharmaceuticals
- Intermediates & Fine Chemicals
- 杂质-地塞米松杂质
- 杂质
- 地塞米松杂质
- 医药研发中间体
- 对照品-杂质对照品
- 178-糠酸莫米松
- 标准品
- 杂质对照品
- 地塞米松杂质5(地塞米松EP杂质E)
- (16Α)-17,21-二羟基-16-甲基预浸基-1,4,9(11)-三烯-3,20-二酮
- 艾美龙
- 糠酸莫米松杂质22
- 地塞米松磷酸钠杂质E
- 地塞米松磷酸钠杂质EP F
- 地塞米松磷酸钠杂质EP E
- 地塞米松EP杂质E
- 地塞米松杂质杂质E
- 16Α-甲基-9,11-脱氢泼尼松龙
- 地塞米松杂质E(EP)
- 13209-41-1
- Carbamazepine Impurity 22
- Pregna-1,4,9(11)-triene-3,20-dione, 17,21-dihydroxy-16-methyl-, (16α)-
- 16α-Methyl-9,11-dehydro Prednisolone
- inhibit,repair,Mineralocorticoid Receptor,VBP 15,Glucocorticoid Receptor,NF-κB,inflammation,Duchenne,Inhibitor,membrane,dystrophy,Vamorolone,Nuclear factor-κB,Nuclear factor-kappaB,muscular,VBP-15,glucocorticoid
- VBP15
- ethyl (8S,9R,10S,11S,13S,14S,16R,17R)-9-fluoro-11,17-dihydroxy-10,13,16-trimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthrene-17-carboxylate
- 17, 21-dihydroxy-16α-methylpregna- 1, 4, 9(11)-triene-3,20-dione
- ((2R,3R,4aS,4bS,10aS,10bR,11S,12aS)-10b-fluoro-2,11-dihydroxy-3,10a,12a-trimethyl-1,8-dioxo-1,2,3,4,4a,4b,5,6,8,10a,10b,11,12,12a-tetradecahydrochrysen-2-yl)methyl dihydrogen phosphate
- (8S,10S,13S,14S,16R,17R)-17-hydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-6,7,8,10,12,13,14,15,16,17-decahydro-3H-cyclopenta[a]phenanthren-3-one
- Dexamethasone EP Imp E
- (8S,10S,13S,14S,16R,17R)-17-hydroxy
- Dexamethasone Impurity L
- Dexamethasone Impurity 5(Dexamethasone EP Impurity E)
- Dexamethasone impurity E
- 17.alpha.,21-Dihydroxy-16.alpha.-methylpregna-1,4,9(11)-triene-3,20-dione
- (16α)-17,21-Dihydroxy-16-Methylpregna-1,4,9(11)-triene-3,20-dione
- 16α-Methyl-9,11-dehydro Prednisolone
- 17,21-dihydroxy-16alpha-methylpregna-1,4,9(11)-triene-3,20-dione