地塞米松EP杂质E
中文名称 | 地塞米松EP杂质E |
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中文同义词 | 地塞米松杂质E(EP);16Α-甲基-9,11-脱氢泼尼松龙;地塞米松杂质杂质E;地塞米松EP杂质E;地塞米松磷酸钠杂质EP E;地塞米松磷酸钠杂质EP F;地塞米松磷酸钠杂质E;糠酸莫米松杂质22 |
英文名称 | Dexamethasone EP Impurity E |
英文同义词 | 17,21-dihydroxy-16alpha-methylpregna-1,4,9(11)-triene-3,20-dione;16α-Methyl-9,11-dehydro Prednisolone;(16α)-17,21-Dihydroxy-16-Methylpregna-1,4,9(11)-triene-3,20-dione;17.alpha.,21-Dihydroxy-16.alpha.-methylpregna-1,4,9(11)-triene-3,20-dione;Dexamethasone impurity E;Dexamethasone Impurity 5(Dexamethasone EP Impurity E);Dexamethasone Impurity L;(8S,10S,13S,14S,16R,17R)-17-hydroxy |
CAS号 | 13209-41-1 |
分子式 | C22H28O4 |
分子量 | 356.46 |
EINECS号 | 236-177-8 |
相关类别 | 杂质对照品;标准品;178-糠酸莫米松;对照品-杂质对照品;医药研发中间体;地塞米松杂质;杂质;Intermediates & Fine Chemicals;Pharmaceuticals;Steroids |
Mol文件 | 13209-41-1.mol |
结构式 |
地塞米松EP杂质E 性质
熔点 | 228-231 °C(Solv: acetone (67-64-1); hexane (110-54-3)) |
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沸点 | 548.3±50.0 °C(Predicted) |
密度 | 1.24±0.1 g/cm3(Predicted) |
储存条件 | Refrigerator |
溶解度 | 氯仿(微溶)、二恶烷(微溶)、乙酸乙酯(微溶) |
形态 | 固体 |
酸度系数(pKa) | 12.53±0.70(Predicted) |
颜色 | 淡黄色低 |
Vamorolone (VBP15) inhibits TNFα-induced pro-inflammatory NF-κB signaling in C2C12 muscle cells at 1 nM or more. Vamorolone binds the glucocorticoid receptor (GR) and mineralocorticoid receptor (MR) with similar affinity.
Vamorolone (0.1, 1μM; 30 minutes) reduces production of IL1βand CCL5 inflammatory mediators in primary human macrophages.
Vamorolone is a first-in-class mineralocorticoid receptor (MR) antagonist/dissociative glucocorticoid receptor (GR) ligand.
Vamorolone (5-30 mg/kg; cherry syrup) shows a superior side effect profile compared to pharmacological glucocorticoids in
mdx
mice.
Vamorolone (30 mg/kg; orally; daily for 20 days) reduces CNS Inflammation in murine experimental autoimmune encephalomyelitis.
Animal Model: | C57BL/6 mice (experimental autoimmune encephalomyelitis) |
Dosage: | 30 mg/kg |
Administration: | Orally; daily for 20 days (starting one day prior to MOG 33-55 peptide immunization and continuing) |
Result: | Reduced CNS inflammation in murine experimental autoimmune encephalomyelitis. |