6-氨基-8-[(3,5-二氯苯基)硫基]-N-异丙基-9H-嘌呤-9-丙胺
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- CAS号:
- 1454619-14-7
- 英文名:
- PU-WS13
- 英文别名:
- PU-WS13;CS-2047;CS-1689;PU WS13;PUWS13;8-((3,5-dichlorophenyl)thio)-9-(3-(isopropylamino)propyl)-9H-purin-6-amine;8-(3,5-dichlorophenyl)sulfanyl-9-[3-(propan-2-ylamino)propyl]purin-6-amine;6-Amino-8-[(3,5-dichlorophenyl)thio]-N-(1-methylethyl)-9H-purine-9-propanamine;9H-Purine-9-propanamine, 6-amino-8-[(3,5-dichlorophenyl)thio]-N-(1-methylethyl)-
- 中文名:
- 6-氨基-8-[(3,5-二氯苯基)硫基]-N-异丙基-9H-嘌呤-9-丙胺
- 中文别名:
- PU-WS13 抑制剂;HSP90抑制剂(PU-WS13);6-氨基-8-[(3,5-二氯苯基)硫基]-N-异丙基-9H-嘌呤-9-丙胺
- CBNumber:
- CB22742078
- 分子式:
- C17H20Cl2N6S
- 分子量:
- 411.35
- MOL File:
- 1454619-14-7.mol
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6-氨基-8-[(3,5-二氯苯基)硫基]-N-异丙基-9H-嘌呤-9-丙胺化学性质
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沸点:
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617.4±65.0 °C(Predicted)
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密度:
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1.47±0.1 g/cm3(Predicted)
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储存条件:
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2-8°C(protect from light)
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溶解度:
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DMF: 30 mg/mL,DMSO: 30 mg/mL,DMSO:PBS(pH7.2) (1:1): 0.5 mg/mL,Ethanol: 25 mg/mL
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形态:
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Powder
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酸度系数(pKa):
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10.15±0.29(Predicted)
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6-氨基-8-[(3,5-二氯苯基)硫基]-N-异丙基-9H-嘌呤-9-丙胺性质、用途与生产工艺
PU-WS13 是一种选择性的 Grp94 抑制剂，EC50 值为 0.22 μM。
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GRP94
0.22 μM (EC
50
)
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HSP90α
27.3 μM (EC
50
)
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HSP90β
41.8 μM (EC
50
)
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TRAP-1
7.3 μM (EC
50
)
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PU-WS13 is a Grp94 inhibitor, with an EC
50
of 0.22 μM. PU-WS13 also slightly suppresses Hsp90α, Hsp90β and Trap-1, with EC
50
s of 27.3, 41.8 and 7.3 μM, respectively. PU-WS13 (2.5-20 μM) shows no toxicity on two nonmalignant cell lines. PU-WS13 (15 μM) disrupts the circular architecture of HER2 at the plasma membrane of SKBr3 cells mediated through Grp94. PU-WS13 inhibits Grp94, and the inhibition induces apoptosis in and reduce the viability of HER2 overexpressing breast cancer cells.
6-氨基-8-[(3,5-二氯苯基)硫基]-N-异丙基-9H-嘌呤-9-丙胺
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2022/04/29 | HY-18680 | PU-WS13 | 1454619-14-7 | 5mg | 900元 |
| 2022/04/29 | HY-18680 | PU-WS13 | 1454619-14-7 | 10mM * 1mLin DMSO | 990元 |
6-氨基-8-[(3,5-二氯苯基)硫基]-N-异丙基-9H-嘌呤-9-丙胺
生产厂家
1454619-14-7, 6-氨基-8-[(3,5-二氯苯基)硫基]-N-异丙基-9H-嘌呤-9-丙胺 相关搜索:
- 细胞生物学试剂
- C17H20Cl2N6S
- PU-WS13 抑制剂
- HSP90抑制剂(PU-WS13)
- 6-氨基-8-[(3,5-二氯苯基)硫基]-N-异丙基-9H-嘌呤-9-丙胺
- 1454619-14-7
- 9H-Purine-9-propanamine, 6-amino-8-[(3,5-dichlorophenyl)thio]-N-(1-methylethyl)-
- CS-2047
- CS-1689
- PU WS13;PUWS13
- 8-(3,5-dichlorophenyl)sulfanyl-9-[3-(propan-2-ylamino)propyl]purin-6-amine
- 6-Amino-8-[(3,5-dichlorophenyl)thio]-N-(1-methylethyl)-9H-purine-9-propanamine
- 8-((3,5-dichlorophenyl)thio)-9-(3-(isopropylamino)propyl)-9H-purin-6-amine
- PU-WS13