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PU-WS13

PU-WS13 Struktur
1454619-14-7
CAS-Nr.
1454619-14-7
Englisch Name:
PU-WS13
Synonyma:
PU-WS13;CS-2047;CS-1689;PU WS13;PUWS13;8-((3,5-dichlorophenyl)thio)-9-(3-(isopropylamino)propyl)-9H-purin-6-amine;8-(3,5-dichlorophenyl)sulfanyl-9-[3-(propan-2-ylamino)propyl]purin-6-amine;6-Amino-8-[(3,5-dichlorophenyl)thio]-N-(1-methylethyl)-9H-purine-9-propanamine;9H-Purine-9-propanamine, 6-amino-8-[(3,5-dichlorophenyl)thio]-N-(1-methylethyl)-;8-[(3,5-dichlorophenyl)sulfanyl]-9-{3-[(propan-2-yl)amino]propyl}-9H-purin-6-amine
CBNumber:
CB22742078
Summenformel:
C17H20Cl2N6S
Molgewicht:
411.35
MOL-Datei:
1454619-14-7.mol
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PU-WS13 Eigenschaften

Siedepunkt:
617.4±65.0 °C(Predicted)
Dichte
1.47±0.1 g/cm3(Predicted)
storage temp. 
2-8°C(protect from light)
Löslichkeit
DMF: 30 mg/mL,DMSO: 30 mg/mL,DMSO:PBS(pH7.2) (1:1): 0.5 mg/mL,Ethanol: 25 mg/mL
Aggregatzustand
Powder
pka
10.15±0.29(Predicted)

Sicherheit

PU-WS13 Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

PU-WS13 is an inhibitor of the heat shock protein family member and chaperone protein glucose-regulated protein 94 (GRP94; IC50 = 0.22 μM). It is selective for GRP94 over the chaperones Hsp90α, Hsp90β, and TRAP1 (IC50s = 27.3, 41.8, and 7.3 μM, respectively). PU-WS13 (0.5, 2.5, and 12.5 μM) induces apoptosis without increasing Hsp70 protein levels in HER2-overexpressing SK-BR-3, BT474, and MDA-MB-361 breast cancer cells. It also induces apoptosis and necrosis in multiple myeloma cells but does not induces cell death in pre-B leukemic cells.

Verwenden

PU-WS13 is a pharmaceutical agent used in the preparation go paralog=selective HSP90 inhibitors used in anti-tumor treatments.

PU-WS13 Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

PU-WS13 Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 77)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795
ivan@atkchemical.com China 32836 60
career henan chemical co 		+86-0371-86658258 +8613203830695
 sales@coreychem.com China 29888 58
Chongqing Chemdad Co., Ltd 		+86-023-6139-8061 +86-86-13650506873
 sales@chemdad.com China 39916 58
HANGZHOU CLAP TECHNOLOGY CO.,LTD 		86-571-88216897,88216896 13588875226
 sales@hzclap.com CHINA 6313 58
Zhejiang J&C Biological Technology Co.,Limited 		+1-2135480471 +1-2135480471
 sales@sarms4muscle.com China 10522 58
CD Chemical Group Limited 		+8615986615575
 info@codchem.com China 20356 58
InvivoChem 		+1-708-310-1919 +1-13798911105
 sales@invivochem.cn United States 6393 58
Henan Fengda Chemical Co., Ltd 		+86-371-86557731 +86-13613820652
 info@fdachem.com China 20291 58
SHANGHAI KEAN TECHNOLOGY CO., LTD. 		+8613817748580
 cooperation@kean-chem.com China 40068 58
Amadis Chemical Company Limited 		571-89925085
sales@amadischem.com China 131980 58
  • PU-WS13
  • 8-((3,5-dichlorophenyl)thio)-9-(3-(isopropylamino)propyl)-9H-purin-6-amine
  • 6-Amino-8-[(3,5-dichlorophenyl)thio]-N-(1-methylethyl)-9H-purine-9-propanamine
  • 8-(3,5-dichlorophenyl)sulfanyl-9-[3-(propan-2-ylamino)propyl]purin-6-amine
  • PU WS13;PUWS13
  • CS-1689
  • CS-2047
  • 9H-Purine-9-propanamine, 6-amino-8-[(3,5-dichlorophenyl)thio]-N-(1-methylethyl)-
  • 8-[(3,5-dichlorophenyl)sulfanyl]-9-{3-[(propan-2-yl)amino]propyl}-9H-purin-6-amine
  • 1454619-14-7
  • C17H20Cl2N6S
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