ChemicalBook >> CAS DataBase List >>PU-WS13
PU-WS13
- CAS No.
- 1454619-14-7
- Chemical Name:
- PU-WS13
- Synonyms
- PU-WS13;CS-2047;CS-1689;PU WS13;PUWS13;8-((3,5-dichlorophenyl)thio)-9-(3-(isopropylamino)propyl)-9H-purin-6-amine;8-(3,5-dichlorophenyl)sulfanyl-9-[3-(propan-2-ylamino)propyl]purin-6-amine;6-Amino-8-[(3,5-dichlorophenyl)thio]-N-(1-methylethyl)-9H-purine-9-propanamine;9H-Purine-9-propanamine, 6-amino-8-[(3,5-dichlorophenyl)thio]-N-(1-methylethyl)-
- CBNumber:
- CB22742078
- Molecular Formula:
- C17H20Cl2N6S
- Molecular Weight:
- 411.35
- MDL Number:
- MFCD28156414
- MOL File:
- 1454619-14-7.mol
Last updated:2023-05-18 11:31:06
PU-WS13 price More Price(21)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 18409 | PU-WS13 ≥98% | 1454619-14-7 | 1mg | $36 | 2022-04-27 | Buy |
| Cayman Chemical | 18409 | PU-WS13 ≥98% | 1454619-14-7 | 5mg | $91 | 2022-04-27 | Buy |
| Cayman Chemical | 18409 | PU-WS13 ≥98% | 1454619-14-7 | 10mg | $143 | 2022-04-27 | Buy |
| Cayman Chemical | 18409 | PU-WS13 ≥98% | 1454619-14-7 | 25mg | $269 | 2022-04-27 | Buy |
| TRC | P840335 | PU-WS13 | 1454619-14-7 | 100mg | $790 | 2021-12-16 | Buy |
PU-WS13 Chemical Properties,Uses,Production
Description
PU-WS13 is an inhibitor of the heat shock protein family member and chaperone protein glucose-regulated protein 94 (GRP94; IC50 = 0.22 μM). It is selective for GRP94 over the chaperones Hsp90α, Hsp90β, and TRAP1 (IC50s = 27.3, 41.8, and 7.3 μM, respectively). PU-WS13 (0.5, 2.5, and 12.5 μM) induces apoptosis without increasing Hsp70 protein levels in HER2-overexpressing SK-BR-3, BT474, and MDA-MB-361 breast cancer cells. It also induces apoptosis and necrosis in multiple myeloma cells but does not induces cell death in pre-B leukemic cells.
Uses
PU-WS13 is a pharmaceutical agent used in the preparation go paralog=selective HSP90 inhibitors used in anti-tumor treatments.
PU-WS13 Preparation Products And Raw materials
Raw materials
Preparation Products
Global( 74)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32480 | 60 |
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29914 | 58 |
| Chongqing Chemdad Co., Ltd | +86-023-61398051 +8613650506873 | sales@chemdad.com | China | 39916 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6313 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10523 | 58 |
| CD Chemical Group Limited | +8615986615575 | info@codchem.com | China | 20356 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131981 | 58 |
| Shanghai Boyle Chemical Co., Ltd. | sales@boylechem.com | China | 2923 | 55 | |
| Haoyuan Chemexpress Co., Ltd. | 021-58950125 | info@chemexpress.com | China | 7553 | 61 |
PU-WS13
8-((3,5-dichlorophenyl)thio)-9-(3-(isopropylamino)propyl)-9H-purin-6-amine
6-Amino-8-[(3,5-dichlorophenyl)thio]-N-(1-methylethyl)-9H-purine-9-propanamine
8-(3,5-dichlorophenyl)sulfanyl-9-[3-(propan-2-ylamino)propyl]purin-6-amine
PU WS13;PUWS13
CS-1689
CS-2047
9H-Purine-9-propanamine, 6-amino-8-[(3,5-dichlorophenyl)thio]-N-(1-methylethyl)-
1454619-14-7
C17H20Cl2N6S