ChemicalBook >> CAS DataBase List >>MKT 077
MKT 077
- CAS No.
- 147366-41-4
- Chemical Name:
- MKT 077
- Synonyms
- FJ 776;MKT 077;MKT-077, ≥98% (HPLC);MKT077;MKT-077;FJ-776;MKT-077 >=98% (HPLC), powder;MKT-077,Heat shock proteins,FJ 776,HSP,Inhibitor,inhibit,FJ776;1-Ethyl-2-[[3-ethyl-5-(3-methyl-2(3H)-benzothiazolylidene)-4-oxo-2-thiazolidinylidene]methyl]-pyridinium chloride;Pyridinium, 1-ethyl-2-[[3-ethyl-5-(3-methyl-2(3H)-benzothiazolylidene)-4-oxo-2-thiazolidinylidene]methyl]-, chloride (1:1);1-Ethyl-2-((Z)-((Z)-3-ethyl-5-(3-methylbenzo[d]thiazol-2(3H)-ylidene)-4-oxothiazolidin-2-ylidene)methyl)pyridin-1-ium chloride
- CBNumber:
- CB31356358
- Molecular Formula:
- C21H22ClN3OS2
- Molecular Weight:
- 432.00188
- MDL Number:
- MFCD00953420
- MOL File:
- 147366-41-4.mol
- MSDS File:
- SDS
Last updated:2023-06-30 15:45:59
| storage temp. | 2-8°C |
|---|---|
| solubility | H2O: soluble10mg/mL, clear |
| form | powder |
| color | orange to red |
| FDA UNII | 8PF5ZXI0JE |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
| WGK Germany | 3 |
| RTECS | UU4023332 |
| Toxicity | LD50 intraperitoneal in mouse: 50mg/kg |
MKT 077 price More Price(24)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | M5449 | MKT-077 ≥98% (HPLC), powder | 147366-41-4 | 5mg | $195 | 2024-03-01 | Buy |
| Sigma-Aldrich | M5449 | MKT-077 ≥98% (HPLC), powder | 147366-41-4 | 25mg | $309.6 | 2024-03-01 | Buy |
| Cayman Chemical | 14395 | MKT-077 ≥95% | 147366-41-4 | 1mg | $36 | 2024-03-01 | Buy |
| Cayman Chemical | 14395 | MKT-077 ≥95% | 147366-41-4 | 5mg | $117 | 2024-03-01 | Buy |
| Cayman Chemical | 14395 | MKT-077 ≥95% | 147366-41-4 | 10mg | $162 | 2024-03-01 | Buy |
MKT 077 Chemical Properties,Uses,Production
Description
MKT-077 is a cationic rhodacyanine dye that demonstrates antiproliferative activity against cancer cell lines (EC50s = 1.4-2.2 μM in vitro) through its ability to inhibit members of the heat shock protein 70 (Hsp70) family of molecular chaperones. It has been shown to bind to an allosteric site conserved in Hsp70 family members, interfering with ATP hydrolysis and abrogating the interaction of the chaperone with the tumor suppressor p53.
Uses
MKT-077 is used in the treatment of Alzheimer’s diseases and other tauopathie’s. Also, is a rhodacyanine derivative that selectively targets cancer cells and overcomes tamoxifen resistance
Biochem/physiol Actions
MKT-077 is an inhibitor of mitochondrial hsp70 family member, mortalin (mot-2)n; causes selective death of cancer cells.
storage
Store at +4°C
MKT 077 Preparation Products And Raw materials
Raw materials
Preparation Products
MKT 077 Suppliers
Global( 70)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32480 | 60 |
| career henan chemical co | +86-0371-86658258 15093356674; | factory@coreychem.com | China | 29826 | 58 |
| SHANGHAI T&W PHARMACEUTICAL CO., LTD. | +86-021-61551413 +8618813727289 | contact@trustwe.com | China | 5738 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6313 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
| Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd | +86-18341751992 +86-15382112998 | 757984502@qq.com | China | 892 | 58 |
| LEAPCHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 43348 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131981 | 58 |
MKT 077
FJ 776
1-Ethyl-2-[[3-ethyl-5-(3-methyl-2(3H)-benzothiazolylidene)-4-oxo-2-thiazolidinylidene]methyl]-pyridinium chloride
MKT-077, ≥98% (HPLC)
1-Ethyl-2-((Z)-((Z)-3-ethyl-5-(3-methylbenzo[d]thiazol-2(3H)-ylidene)-4-oxothiazolidin-2-ylidene)methyl)pyridin-1-ium chloride
MKT-077 >=98% (HPLC), powder
Pyridinium, 1-ethyl-2-[[3-ethyl-5-(3-methyl-2(3H)-benzothiazolylidene)-4-oxo-2-thiazolidinylidene]methyl]-, chloride (1:1)
MKT077;MKT-077;FJ-776
MKT-077,Heat shock proteins,FJ 776,HSP,Inhibitor,inhibit,FJ776
147366-41-4
C21H22ClN3OS2