307002-71-7
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- CAS号:
- 307002-71-7
- 英文名:
- CL 82198 HYDROCHLORIDE
- 英文别名:
- CL-82198
(CL82198;CL 82198 hydrochlori;CL 82198 HYDROCHLORIDE;N-(4-Morpholinobutyl)benzofuran-2-carboxamide;N-[4-(4-Morpholinyl)butyl]-2-benzofurancarboxamide;2-Benzofurancarboxamide, N-[4-(4-morpholinyl)butyl]-;Benzofuran-2-carboxylic acid (4-morpholin-4-yl-butyl)-amide;N-(4-Morpholinobutyl)benzofuran-2-carboxamide hydrochloride;N-[4-(4-MORPHOLINYL)BUTYL]-2-BENZOFURANCARBOXAMIDE HYDROCHLORIDE;N-(4-morpholin-4-ylbutyl)-1-benzofuran-2-carboxamide,hydrochloride
- 中文名:
- 307002-71-7
- 中文别名:
- 化合物CL-82198;CL-82198,MMP-13抑制剂;N-(4-吗啉丁基)苯并呋喃-2-甲酰胺
- CBNumber:
- CB42450342
- 分子式:
- C17H22N2O3
- 分子量:
- 302.37
- MOL File:
- 307002-71-7.mol
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307002-71-7化学性质
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沸点:
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515.6±40.0 °C(Predicted)
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密度:
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1.159±0.06 g/cm3(Predicted)
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储存条件:
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2-8°C
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溶解度:
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DMSO: >10mg/mL
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酸度系数(pKa):
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14.19±0.46(Predicted)
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形态:
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powder
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颜色:
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white to off-white
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稳定性:
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Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 6 months.
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307002-71-7性质、用途与生产工艺
CL-82198 是一个选择性的 MMP-13 抑制剂。CL-82198 与 MMP-13 的整个 S1' 口袋结合，这是其对 MMP-13 选择性和对其他 MMP 缺乏抑制活性的基础。CL-82198 可用于骨关节炎 (OA) 的研究。
CL-82198 (10 μM; 24 hours) significantly reduces LS174 cell migration.
CL-82198 decreases CTGF and TGF-β1 protein levels in hepatic stellate cells.
CL82198 (1-10 mg/kg; i.p.; every other day for 12 weeks) prevents and decelerates MLI-induced osteoarthritis progression.
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Animal Model:
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10-week-old C57BL/6J mice (performed MLI surgery)
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Dosage:
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1, 5, 10 mg/kg body weight
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Administration:
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Intraperitoneal injection; every other day for 12 weeks
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Result:
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Prevented and decelerated MLI-induced osteoarthritis progression.
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307002-71-7
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307002-71-7, 307002-71-7 相关搜索:
- Angiogenesis and Metastasis
- Protease inhibitor
- 合成有机化合物配体
- C17H33N2O3HCl
- CL-82198,MMP-13抑制剂
- 化合物CL-82198
- N-(4-吗啉丁基)苯并呋喃-2-甲酰胺
- 307002-71-7
- Inhibitor,CL-82198,CL82198,MMP,inhibit,Matrix metalloproteinases,CL 82198
- N-(4-Morpholinobutyl)benzofuran-2-carboxamide
- CL 82198 hydrochlori
- 2-Benzofurancarboxamide, N-[4-(4-morpholinyl)butyl]-
- CL-82198
(CL82198
- Benzofuran-2-carboxylic acid (4-morpholin-4-yl-butyl)-amide
- N-(4-Morpholinobutyl)benzofuran-2-carboxamide hydrochloride
- N-(4-morpholin-4-ylbutyl)-1-benzofuran-2-carboxamide,hydrochloride
- N-[4-(4-Morpholinyl)butyl]-2-benzofurancarboxamide
- N-[4-(4-MORPHOLINYL)BUTYL]-2-BENZOFURANCARBOXAMIDE HYDROCHLORIDE
- CL 82198 HYDROCHLORIDE