CS-2757
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- CAS号:
- 1118460-77-7
- 英文名:
- UCPH-101
- 英文别名:
- CS-2757;UCPH-101;UCPH-101; UCPH 101; UCPH101;inhibit,UCPH101,UCPH-101,Inhibitor;2-Amino-4-(4-methoxy-phenyl)-7-naphthalen-1-yl-5-oxo-5,6,7,8-tetrahydro-4H-chromene-3-carbonitrile;2-Amino-5,6,7,8-tetrahydro-4-(4-methoxyphenyl)-7-(naphthalen-1-yl)-5-oxo-4H-chromene-3-carbonitrile;2-amino-4-(4-methoxyphenyl)-7-(naphthalene-1-yl)-5-oxo-5,6,7,8-tetrahydro-4H-chromene-3-carbonitrile;4H-1-Benzopyran-3-carbonitrile, 2-aMino-5,6,7,8-tetrahydro-4-(4-Methoxyphenyl)-7-(1-naphthalenyl)-5-oxo-
- 中文名:
- CS-2757
- 中文别名:
- 化合物UCPH101;UCPH-101,EAAT1抑制剂;2-氨基-4-(4-甲氧基苯基)-7-(萘-1-基)-5-氧代-5,6,7,8-四氢-4H-苯并吡喃-3-甲腈
- CBNumber:
- CB42487582
- 分子式:
- C27H22N2O3
- 分子量:
- 422.48
- MOL File:
- 1118460-77-7.mol
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CS-2757化学性质
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熔点:
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194.0-197.2 °C
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沸点:
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703.5±60.0 °C(Predicted)
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密度:
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1.32±0.1 g/cm3(Predicted)
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储存条件:
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Keep in dark place,Inert atmosphere,2-8°C
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溶解度:
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Soluble in DMSO (up to 10 mg/ml).
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形态:
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solid
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酸度系数(pKa):
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3.23±0.60(Predicted)
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颜色:
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Off-white
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稳定性:
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Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.
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CS-2757性质、用途与生产工艺
UCPH-101 是一种 excitatory amino acid transporter subtype 1 (EAAT1) 的抑制剂,在EAAT1-HEK293细胞中通过[3H]-D-Asp uptake assay测定的IC50值为0.66 μM。
Target | Value |
EAAT1
(in EAAT1-HEK293 cells)
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0.66 μM
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UCPH-101 and UCPH-102 inhibit EAAT1 anion currents in a concentration-dependent manner, with K
D
values of 0.34±0.03 μM (Hill=1.3±0.13, n≥9) for UCPH-101 and 0.17±0.02 μM (Hill=0.97±0.11, n≥7) for UCPH-102. A small but significant decrease in the total expression levels of both HA-EAAT1 and HA-GLAST is observed in cells preincubated with 100 μM UCPH-101 (p=0.048).
CS-2757
上下游产品信息
上游原料
下游产品
更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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2024/04/30 | HY-10914 | UCPH-101 | | 1 mg | 727元 |
2024/04/30 | S0297 | CS-2757 UCPH-101 | 1118460-77-7 | 5mg | 1675元 |
1118460-77-7, CS-2757 相关搜索:
- Glutamate
- 合成有机化合物配体
- UCPH-101,EAAT1抑制剂
- 化合物UCPH101
- 2-氨基-4-(4-甲氧基苯基)-7-(萘-1-基)-5-氧代-5,6,7,8-四氢-4H-苯并吡喃-3-甲腈
- 1118460-77-7
- inhibit,UCPH101,UCPH-101,Inhibitor
- 2-amino-4-(4-methoxyphenyl)-7-(naphthalene-1-yl)-5-oxo-5,6,7,8-tetrahydro-4H-chromene-3-carbonitrile
- CS-2757
- UCPH-101; UCPH 101; UCPH101
- 2-Amino-4-(4-methoxy-phenyl)-7-naphthalen-1-yl-5-oxo-5,6,7,8-tetrahydro-4H-chromene-3-carbonitrile
- 4H-1-Benzopyran-3-carbonitrile, 2-aMino-5,6,7,8-tetrahydro-4-(4-Methoxyphenyl)-7-(1-naphthalenyl)-5-oxo-
- 2-Amino-5,6,7,8-tetrahydro-4-(4-methoxyphenyl)-7-(naphthalen-1-yl)-5-oxo-4H-chromene-3-carbonitrile
- UCPH-101