HDAC6 Inhibitor
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- CAS号:
- 1045792-66-2
- 英文名:
- CAY10603
- 英文别名:
- Isox;187257;BML-281;CAY10603;HDAC6 Inhibitor;CAY10603
CAY10603;HDAC6 inhibitor ISOX;CAY10603; CAY-10603; CAY 10603.;Histone Deacetylase Inhibitor VIII - CAS 1045792-66-2 - Calbiochem;tert-butyl 4-(3-((7-(hydroxyamino)-7-oxoheptyl)carbamoyl)isoxazol-5-yl)phenylcarbamate
- 中文名:
- HDAC6 Inhibitor
- 中文别名:
- 化合物CAY10603;HDAC6抑制剂(CAY10603);(4-(3-((7-(羟基氨基)-7-氧代庚基)氨基甲酰)异恶唑-5-基)苯基)氨基甲酸叔丁酯;N-[4-[3-[[[7-(羟基氨基)-7-氧代庚基]氨基]羰基]-5-异恶唑基]苯基]氨基甲酸叔丁酯
- CBNumber:
- CB42590439
- 分子式:
- C22H30N4O6
- 分子量:
- 446.5
- MOL File:
- 1045792-66-2.mol
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HDAC6 Inhibitor化学性质
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密度:
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1.231±0.06 g/cm3(Predicted)
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储存条件:
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+2C to +8C
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溶解度:
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≥22.35 mg/mL in DMSO; insoluble in EtOH; ≥24.85 mg/mL in H2O
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形态:
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Beige to light brown solid
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酸度系数(pKa):
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9.47±0.20(Predicted)
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颜色:
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White to light yellow
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HDAC6 Inhibitor性质、用途与生产工艺
CAY10603是一种强效的选择性HDAC6抑制剂,IC50为2 pM,选择性比其它HDACs高200多倍。
CAY10603, via inhibition of HDAC6, shows potent antiproliferative activity against pancreatic cancer cell lines with IC50 of <1 μM, which can be used as a new molecular probe in exploring HDAC biology.
CAY10603 (BML-281)是一种强效的选择性HDAC6抑制剂,IC50为2 pM,选择性比其它HDACs高200多倍。
Target | Value |
HDAC6
(Cell-free assay)
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2 pM
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CAY10603,通过抑制HDAC6,对胰腺癌细胞系表现出有效的抗增殖活性,IC50 <1 μM,其可以用作新的分子探针以探索HDAC的生物学性能。
HDAC6 Inhibitor
上下游产品信息
上游原料
下游产品
更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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2024/08/19 | HY-18613 | CAY10603 | | 1 mg | 440元 |
2024/08/19 | HY-18613 | HDAC6 Inhibitor CAY10603 | 1045792-66-2 | 10mM * 1mLin DMSO | 1081元 |
1045792-66-2, HDAC6 Inhibitor 相关搜索:
- Inhibitors
- 合成有机化合物配体
- 标准品
- 细胞生物学试剂
- 小分子抑制剂,天然产物
- 小分子抑制剂
- 化合物CAY10603
- (4-(3-((7-(羟基氨基)-7-氧代庚基)氨基甲酰)异恶唑-5-基)苯基)氨基甲酸叔丁酯
- HDAC6抑制剂(CAY10603)
- N-[4-[3-[[[7-(羟基氨基)-7-氧代庚基]氨基]羰基]-5-异恶唑基]苯基]氨基甲酸叔丁酯
- 1045792-66-2
- CAY10603
CAY10603
- BML 281,inhibit,Histone deacetylases,BML281,CAY-10603,Inhibitor,CAY10603,CAY 10603,HDAC
- Carbamic acid, N-[4-[3-[[[7-(hydroxyamino)-7-oxoheptyl]amino]carbonyl]-5-isoxazolyl]phenyl]-, 1,1-dimethylethyl ester
- BML-281
- tert-butyl N-[4-[3-[[7-(hydroxyamino)-7-oxoheptyl]carbamoyl]-1,2-oxazol-5-yl]phenyl]carbamate
- 187257
- CAY10603; CAY-10603; CAY 10603.
- Histone Deacetylase Inhibitor VIII - CAS 1045792-66-2 - Calbiochem
- HDAC6 Inhibitor
- tert-butyl 4-(3-((7-(hydroxyamino)-7-oxoheptyl)carbamoyl)isoxazol-5-yl)phenylcarbamate
- Isox
- CAY10603
- HDAC6 inhibitor ISOX
- N-[4-[3-[[[7-(Hydroxyamino)-7-oxoheptyl]amino]carbonyl]-5-isoxazolyl]phenyl]carbamic acid 1,1-dimethylethyl ester