N-[2-(4'-氰基联苯-4-基)丙基]-2-丙烷磺酰胺
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- CAS号:
- 211311-95-4
- 英文名:
- N-(2-(4'-cyanobiphenyl-4-yl)propyl)propane-2-sulfonaMide
- 英文别名:
- 100775;CS-2739;LY40418;LY404187;LY-404187; LY 404187;N-(2-(4'-cyanobiphenyl-4-yl)propyl)propane-2-sulfonaMide;N-2-(4-(4-Cyanophenyl)phenyl)propyl-2-propanesulfonamide;N-(2-(4'-cyanobiphenyl-4-yl)propyl)propane-2-sulfonamide;N-[2-[4-(4-Cyanophenyl)phenyl]propyl]propane-2-sulfonamide;N-[2-(4'-Cyano[1,1'-biphenyl]-4-yl)propyl]-2-propanesulfonamide
- 中文名:
- N-[2-(4'-氰基联苯-4-基)丙基]-2-丙烷磺酰胺
- 中文别名:
- N-[2-(4'-氰基联苯-4-基)丙基]-2-丙烷磺酰胺;N-[2-[4-(4-氰基苯基)苯基]丙基]丙烷-2-磺酰胺
- CBNumber:
- CB42640286
- 分子式:
- C19H22N2O2S
- 分子量:
- 342.46
- MOL File:
- 211311-95-4.mol
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N-[2-(4'-氰基联苯-4-基)丙基]-2-丙烷磺酰胺化学性质
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沸点:
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519.0±60.0 °C(Predicted)
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密度:
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1.19±0.1 g/cm3(Predicted)
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储存条件:
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Sealed in dry,Room Temperature
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溶解度:
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DMF: 15mg/mL; DMSO: 15mg/mL; DMSO:PBS (pH 7.2) (1:4): 0.2mg/mL; Ethanol: 3mg/mL
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形态:
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A solid
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酸度系数(pKa):
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11.24±0.40(Predicted)
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N-[2-(4'-氰基联苯-4-基)丙基]-2-丙烷磺酰胺性质、用途与生产工艺
LY-404187 是有效的，选择性和中枢活性的 AMPA 受体的正变构调节剂，作用于 GluR1i，GluR2i，GluR2o，GluR3i 和 GluR4i 的 EC50 值分别为 5.65、0.15、1.44、1.66 和 0.21 µM。LY-404187 有潜力用于许多精神疾病和神经退行性疾病的研究。
EC50: 5.65 µM (GluR1i), 0.15 µM (GluR2i), 1.44 µM (GluR2o), 1.66 µM (GluR3i), 0.21 µM (GluR4i)
LY-404187 (3-10 nM) potentiates glutamate-evoked inward currents in human GluR4 transfected HEK293 cells.
LY-404187 (0.03-10 µM) selectively enhances glutamate-evoked currents through AMPA receptor/channels of acutely isolated pyramidal neurons with considerably greater potency (EC
50
=1.3±0.3 µM) and efficacy (E
max
=45.3±8.0-fold increase) .
LY-404187 does not affect the magnitude or time course of wholecell K
+
or Na
+
currents in pre frontal cortex (PFC) pyramidal neurons at concentrations of 10 µM.
LY-404187 (0.5 mg/kg; s.c for 11 days) can prevent MPTP-induced neurotoxicity in mice.
LY-404187 (0.5 mg/kg; s.c. for 28 days) attenuates apomorphine-induced contraversive rotations and affords significant protection against the loss of tyrosine hydroxylase positive nigral cell bodies.
LY-404187 (0.1 or 0.5 mg/kg; s.c. for 14 days) affords functional, neurochemical and histological protection after infusion of 6-hydroxydopamine into the substantia nigra in rats.
LY-404187 (0.5 mg/kg; s.c. for 14 days) delayed treatment provides functional and histological improvement, suggesting a trophic action as administration is initiated after cell death.
LY-404187 (0.1 and 0.5 mg/kg; s.c. for 14 days) increases GAP-43 immunoreactivity in the striatum in a dose-dependent manner.
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Animal Model:
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Male C57BL/6J mice (20-25 g) are challenged with MPTP on day 8
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Dosage:
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0.5 mg/kg
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Administration:
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S.c; twice daily on weekdays and once daily at weekends for 11 days
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Result:
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Attenuated the loss of tyrosine hydroxylase immunoreactivity in the substantia nigra.
No significant change in tyrosine hydroxylase immunoreactivity in the dorsal and ventral striatum.
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N-[2-(4'-氰基联苯-4-基)丙基]-2-丙烷磺酰胺
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/04/30 | HY-13456 | LY-404187 | | 1 mg | 400元 |
| 2024/04/30 | HY-13456 | N-[2-(4'-氰基联苯-4-基)丙基]-2-丙烷磺酰胺
LY-404187 | 211311-95-4 | 5 mg | 1000元 |
N-[2-(4'-氰基联苯-4-基)丙基]-2-丙烷磺酰胺
生产厂家
211311-95-4, N-[2-(4'-氰基联苯-4-基)丙基]-2-丙烷磺酰胺 相关搜索:
- N-[2-[4-(4-氰基苯基)苯基]丙基]丙烷-2-磺酰胺
- N-[2-(4'-氰基联苯-4-基)丙基]-2-丙烷磺酰胺
- 211311-95-4
- N-(2-(4'-cyanobiphenyl-4-yl)propyl)propane-2-sulfonamide
- LY40418
- GluR2o,inhibit,Allosteric,GluR3i,iGluR,GluR4i,AMPA,Ionotropic glutamate receptors,GluR1i,LY-404187,psychiatric,LY404187,Inhibitor,GluR2i,LY 404187,neurodegenerative
- N-[2-[4-(4-Cyanophenyl)phenyl]propyl]propane-2-sulfonamide
- 2-Propanesulfonamide, N-[2-(4'-cyano[1,1'-biphenyl]-4-yl)propyl]-
- LY-404187; LY 404187
- 100775
- CS-2739
- LY-404187 N-(2-(4'-cyanobiphenyl-4-yl)propyl)propane-2-sulfonaMide
- N-2-(4-(4-Cyanophenyl)phenyl)propyl-2-propanesulfonamide
- N-[2-(4'-Cyano[1,1'-biphenyl]-4-yl)propyl]-2-propanesulfonamide
- N-(2-(4'-Cyano-[1,1'-biphenyl]-4-yl)propyl)propane-2-sulfonaMide
- LY404187
- N-(2-(4'-cyanobiphenyl-4-yl)propyl)propane-2-sulfonaMide