网站主页 >> CAS数据库列表 >> 1-(2,3-二氢-1,4-苯并二恶烷-5-基)-4-[[5-(4-氟苯基)-3-吡啶基]甲基]哌嗪
1-(2,3-二氢-1,4-苯并二恶烷-5-基)-4-[[5-(4-氟苯基)-3-吡啶基]甲基]哌嗪
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- CAS号:
- 222551-17-9
- 英文名:
- adoprazine
- 英文别名:
- SLV313;SLV 313;adoprazine;Unii-7snb18Q89d;Adoprazine (SLV313);SLV 313;SLV313;SLV-313;1-(2,3-Dihydro-1,4-benzodioxin-5-yl)-4-[[5-(4-fluorophenyl)-3-pyridinyl]methyl]piperazine;Piperazine, 1-(2,3-dihydro-1,4-benzodioxin-5-yl)-4-[[5-(4-fluorophenyl)-3-pyridinyl]methyl]-
- 中文名:
- 1-(2,3-二氢-1,4-苯并二恶烷-5-基)-4-[[5-(4-氟苯基)-3-吡啶基]甲基]哌嗪
- 中文别名:
- 阿哆嗪;化合物 T10249;1-(2,3-二氢-1,4-苯并二恶烷-5-基)-4-[[5-(4-氟苯基)-3-吡啶基]甲基]哌嗪
- CBNumber:
- CB51518488
- 分子式:
- C24H24FN3O2
- 分子量:
- 405.46
- MOL File:
- 222551-17-9.mol
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1-(2,3-二氢-1,4-苯并二恶烷-5-基)-4-[[5-(4-氟苯基)-3-吡啶基]甲基]哌嗪化学性质
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沸点:
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565.0±50.0 °C(Predicted)
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密度:
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1.256
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储存条件:
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Store at -20°C
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溶解度:
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DMSO : 50 mg/mL (123.32 mM; Need ultrasonic)H2O : < 0.1 mg/mL (insoluble)
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形态:
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Powder
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酸度系数(pKa):
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6.07±0.10(Predicted)
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颜色:
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Light yellow to yellow
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1-(2,3-二氢-1,4-苯并二恶烷-5-基)-4-[[5-(4-氟苯基)-3-吡啶基]甲基]哌嗪性质、用途与生产工艺
Adoprazine (SLV313) 是 5-HT 1A 受体的完全激动剂,其在 h5-HT1A 受体的 pEC50 为 9。Adoprazine (SLV313) 是 D2 和 D3 受体的完全拮抗剂,在 hD2 受体中的 pA2 值是 9.3,在 hD3 受体中的 pA2 值是 8.9。Adoprazine (SLV313) 具有非典型抗精神病的特征。
5-HT
1A
Receptor
9 (pEC
50
)
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D
2
Receptor
9.3 (pA2)
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D
3
Receptor
8.9 (pA2)
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D
4
Receptor
8.0 (pKi)
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5-HT
7
Receptor
7.2 (pKi)
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5-HT
1A
Receptor
9.1 (pKi)
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D
2
Receptor
8.4 (pKi)
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D
3
Receptor
8.4 (pKi)
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Adoprazine (SLV313) has high affinity at human recombinant D
2
, D
3
, D
4
, 5-HT
2B
, and 5-HT
1A
receptors, with
pK
i
s of 8.4, 8.4, 8.0, 7.9 and 9.1, respectively.
Adoprazine (SLV313) acts as a high potency dopamine D
2
receptor antagonist and an efficacious serotonin 5-HT
1A
receptor agonist, with E
max
value (% effect of 10 μM 5-HT) of 73 and pK
B
value of 8.5 .
Adoprazine (SLV313) (0.1-10 mg/kg; p.o.; single) is sufficient to reduce extracellular 5-HT and increase dopamine levels in the nucleus accumbens in a dose- and time-dependent manner.
Animal Model:
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Male Wistar rats (275-350 g)
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Dosage:
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0.1 mg/kg, 0.3 mg/kg, 1 mg/kg, 3 mg/kg, 10 mg/kg
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Administration:
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p.o.; single
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Result:
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Led to a dose- and time-dependent increase in extracellular levels of DA, DOPAC, and HVA. In contrast, led to a reduction in 5-HT levels and no change in 5-HIAA levels.
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1-(2,3-二氢-1,4-苯并二恶烷-5-基)-4-[[5-(4-氟苯基)-3-吡啶基]甲基]哌嗪
上下游产品信息
上游原料
下游产品
更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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2024/08/19 | HY-14782 | 1-(2,3-二氢-1,4-苯并二恶烷-5-基)-4-[[5-(4-氟苯基)-3-吡啶基]甲基]哌嗪 Adoprazine | 222551-17-9 | 5mg | 1400元 |
2024/08/19 | HY-14782 | 1-(2,3-二氢-1,4-苯并二恶烷-5-基)-4-[[5-(4-氟苯基)-3-吡啶基]甲基]哌嗪 Adoprazine | 222551-17-9 | 10mM * 1mLin DMSO | 1540元 |
1-(2,3-二氢-1,4-苯并二恶烷-5-基)-4-[[5-(4-氟苯基)-3-吡啶基]甲基]哌嗪
生产厂家
222551-17-9, 1-(2,3-二氢-1,4-苯并二恶烷-5-基)-4-[[5-(4-氟苯基)-3-吡啶基]甲基]哌嗪 相关搜索:
- G蛋白偶联受体&G蛋白
- 化合物 T10249
- 阿哆嗪
- 1-(2,3-二氢-1,4-苯并二恶烷-5-基)-4-[[5-(4-氟苯基)-3-吡啶基]甲基]哌嗪
- 222551-17-9
- Piperazine, 1-(2,3-dihydro-1,4-benzodioxin-5-yl)-4-[[5-(4-fluorophenyl)-3-pyridinyl]methyl]-
- SLV 313;SLV313;SLV-313
- Adoprazine (SLV313)
- SLV313
- SLV 313
- Unii-7snb18Q89d
- 1-(2,3-Dihydro-1,4-benzodioxin-5-yl)-4-[[5-(4-fluorophenyl)-3-pyridinyl]methyl]piperazine
- adoprazine