网站主页 >> CAS数据库列表 >> N-[2-[2-(二甲基氨基)乙氧基]-4-(1H-吡唑-4-基)苯基]-2,3-二氢-1,4-苯并二恶烷-2-甲酰胺
N-[2-[2-(二甲基氨基)乙氧基]-4-(1H-吡唑-4-基)苯基]-2,3-二氢-1,4-苯并二恶烷-2-甲酰胺
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- CAS号:
- 1072959-67-1
- 英文名:
- N-[2-[2-(Dimethylamino)ethoxy]-4-(1H-pyrazol-4-yl)phenyl]-2,3-dihydro-1,4-benzodioxin-2-carboxamide
- 英文别名:
- SR3677;CS-1125;CS-2825;SR-3677; SR 3677;SR 3677 hydrochloride;SR 3677 dihydrochloride;N-(2-(2-(Dimethylamino)ethoxy)-4-(1H-pyrazol-4-yl)phenyl)-2,3-dihydrobenzo[b][1,4]dioxine-2-ca;N-[2-[2-(Dimethylamino)ethoxy]-4-(1H-pyrazol-4-yl)phenyl]-2,3-dihydro-1,4-benzodioxin-2-carboxamide;N-{2-[2-(dimethylamino)ethoxy]-4-(1H-pyrazol-4-yl)phenyl}-2,3-dihydro-1,4-benzodioxine-2-carboxamide;1,4-Benzodioxin-2-carboxamide, N-[2-[2-(dimethylamino)ethoxy]-4-(1H-pyrazol-4-yl)phenyl]-2,3-dihydro-
- 中文名:
- N-[2-[2-(二甲基氨基)乙氧基]-4-(1H-吡唑-4-基)苯基]-2,3-二氢-1,4-苯并二恶烷-2-甲酰胺
- 中文别名:
- 化合物SR-3677;ROCK-II抑制剂(SR-3677);N-[2-[2-(二甲基氨基)乙氧基]-4-(1H-吡唑-4-基)苯基]-2,3-二氢-1,4-苯并二恶烷-2-甲酰胺;N-(2-(2-(二甲基氨基)乙氧基)-4-(1H-吡唑-4-基)苯基)-2,3-二氢苯并[B][1,4]二噁烷-2-甲酰胺
- CBNumber:
- CB52484669
- 分子式:
- C22H24N4O4
- 分子量:
- 408.45
- MOL File:
- 1072959-67-1.mol
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N-[2-[2-(二甲基氨基)乙氧基]-4-(1H-吡唑-4-基)苯基]-2,3-二氢-1,4-苯并二恶烷-2-甲酰胺化学性质
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沸点:
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646.9±55.0 °C(Predicted)
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密度:
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1.298
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储存条件:
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Desiccate at RT
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溶解度:
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DMSO: soluble15mg/mL, clear
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酸度系数(pKa):
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11.90±0.70(Predicted)
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形态:
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powder
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颜色:
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white to light brown
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N-[2-[2-(二甲基氨基)乙氧基]-4-(1H-吡唑-4-基)苯基]-2,3-二氢-1,4-苯并二恶烷-2-甲酰胺性质、用途与生产工艺
SR-3677是高效的选择性的ROCK-II抑制剂,IC50值为~3 nM。
ROCK-II
3 nM (IC
50
)
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ROCK-I
56 nM (IC
50
)
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SR-3677 has an IC
50
of ~3 nM in enzyme and cell based assays and has an off-target hit rate of 1.4% against 353 kinases, and inhibits only 3 out of 70 nonkinase enzymes and receptors. The IC
50
value of SR-3677 for ROCK-I is 56±12 nM. The hydrophobic interaction of the benzodioxane phenyl ring with the hydrophobic surface of the pocket is the dominating factor that contributes to the high potency of SR-3677.
ExVivo: Pharmacology studies shows that SR-3677 is efficacious in both, increasing
ex vivo
aqueous humor outflow in porcine eyes and inhibiting myosin light chain phosphorylation. Continuous exposure of 25 µM SR-3677 increases the outflow facility by 60% at 1 h perfusion, increasing to 70–80% for the 2–5 h time points.
N-[2-[2-(二甲基氨基)乙氧基]-4-(1H-吡唑-4-基)苯基]-2,3-二氢-1,4-苯并二恶烷-2-甲酰胺
上下游产品信息
上游原料
下游产品
更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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2024/08/19 | HY-13300 | SR-3677 | | 5 mg | 600元 |
2024/08/19 | HY-13300 | N-[2-[2-(二甲基氨基)乙氧基]-4-(1H-吡唑-4-基)苯基]-2,3-二氢-1,4-苯并二恶烷-2-甲酰胺 SR-3677 | 1072959-67-1 | 10mM * 1mLin DMSO | 660元 |
N-[2-[2-(二甲基氨基)乙氧基]-4-(1H-吡唑-4-基)苯基]-2,3-二氢-1,4-苯并二恶烷-2-甲酰胺
生产厂家
1072959-67-1, N-[2-[2-(二甲基氨基)乙氧基]-4-(1H-吡唑-4-基)苯基]-2,3-二氢-1,4-苯并二恶烷-2-甲酰胺 相关搜索:
- 酶
- 细胞生物学试剂
- C22H24N4O4HCl
- 072959-67-1
- N-(2-(2-(二甲基氨基)乙氧基)-4-(1H-吡唑-4-基)苯基)-2,3-二氢苯并[B][1,4]二噁烷-2-甲酰胺
- 化合物SR-3677
- ROCK-II抑制剂(SR-3677)
- N-[2-[2-(二甲基氨基)乙氧基]-4-(1H-吡唑-4-基)苯基]-2,3-二氢-1,4-苯并二恶烷-2-甲酰胺
- 1072959-67-1
- N-{2-[2-(dimethylamino)ethoxy]-4-(1H-pyrazol-4-yl)phenyl}-2,3-dihydro-1,4-benzodioxine-2-carboxamide
- Inhibitor,Rho-associated protein kinase,Autophagy,SR 3677,Rho-kinase,SR3677,ROCK,ROK,SR-3677,inhibit,Rho-associated kinase
- 1,4-Benzodioxin-2-carboxamide, N-[2-[2-(dimethylamino)ethoxy]-4-(1H-pyrazol-4-yl)phenyl]-2,3-dihydro-
- CS-2825
- SR-3677; SR 3677
- CS-1125
- N-[2-[2-(Dimethylamino)ethoxy]-4-(1H-pyrazol-4-yl)phenyl-2,3-dihydro-1,4-benzodioxin-2-carboxamide dihydrochloride
- N-[2-[2-(Dimethylamino)ethoxy]-4-(1H-pyrazol-4-yl)phenyl]-2,3-dihydro-1,4-benzodioxin-2-carboxamide
- N-[2-[2-(Dimethylamino)ethoxy]-4-(1H-pyrazol-4-yl)phenyl]-2,3-dihydro-benzo[b][1,4]dioxin-2-carboxamide
- N-(2-(2-(Dimethylamino)ethoxy)-4-(1H-pyrazol-4-yl)phenyl)-2,3-dihydrobenzo[b][1,4]dioxine-2-ca
- SR 3677 dihydrochloride
- N-(2-(2-(diMethylaMino)ethoxy)-4-(1H-pyrazol-4-yl)phenyl)-2,3-dihydrobenzo[b][1,4]dioxine-2-carboxaMide
- SR 3677 hydrochloride
- N-[2-[2-(Dimethylamino)ethoxy]-4-(1H-pyrazol-4-yl)phenyl-2,3-dihydro-1,4-benzodioxin-2-carboxamidehydrochloride
- SR3677