吲哚美辛钠
|
|
|
- CAS号:
- 74252-25-8
- 英文名:
- INDOMETHACIN SODIUM SALT TRIHYDRATE
- 英文别名:
- Indometacin Sodium;INDOMETACIN FARNESIL;Sodium salt trihydrate;Indomethacin sodium hydrate;Indomethacin sodium trihydrate;Indomethacin sodium salt 3-hydrate;INDOMETHACIN SODIUM SALT TRIHYDRATE;sodium,2-[1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetate,trihydrate;1H-Indole-3-acetic acid, 1-(4-chlorobenzoyl)-5-methoxy-2-methyl-, sodi um salt, trihydrate;1H-Indole-3-aceticacid, 1-(4-chlorobenzoyl)-5-Methoxy-2-Methyl-, sodiuM salt, hydrate (1:1:3)
- 中文名:
- 吲哚美辛钠
- 中文别名:
- 吲哚美辛钠;吲哚美锌钠;水溶性吲哚美辛;吲哚美辛钠 水溶性;吲哚美辛钠盐三水合物;吲哚美辛钠中文名称:吲哚美辛钠中文同义词:吲哚美辛钠;2-甲基-1-(4-氯苯甲酰基)-5-甲氧基-1H-吲哚-3-乙酸钠;INDOMETHACIN SODIUM SALT TRIHYDRATE英文同义词:SODIUM,2-[1-(4-CHLOROBENZOYL)-5-METHOXY-2-METHYLINDOL-3-YL]ACETATE,TRIHYDRATE
- CBNumber:
- CB81012013
- 分子式:
- C34H40ClNO4
- 分子量:
- 562.146
- MOL File:
- 74252-25-8.mol
|
|
|
吲哚美辛钠化学性质
-
储存条件:
-
4°C, protect from light, stored under nitrogen
-
|
-
溶解度:
-
DMSO: 5 mg/mL (11.53 mM)
-
|
-
水溶解性:
-
Water: 33.33 mg/mL (76.83 mM)
-
|
吲哚美辛钠性质、用途与生产工艺
吲哚美辛钠是在吲哚美辛基础上研制成功可水溶的非甾体类解热镇痛药物，其具有显著的解热、消炎、镇痛、抗风湿，减轻免疫反应、止泻和增加抗菌药物组织血药浓度，改善精液品质等特点。
吲哚美辛钠可用于治疗高热性疾病、治疗胸腔感染、肠炎、腹泻等疾病。
Indomethacin sodium hydrate (Indometacin sodium hydrate) 是一种有效的，可透过血脑屏障的，非选择性的 COX1 和 COX2 抑制剂，在 CHO 细胞中，对人 COX-1 和 COX-2 的 IC50 值分别为 18 nM 和 26 nM。Indomethacin sodium hydrate 通过干扰溶酶体的正常功能来破坏自噬流 (autophagic flux)。
| Target | Value |
COX1
()
|
0.11 μM
|
COX2
()
|
0.78 μM
|
Indomethacin is a potent and nonselective inhibitor of
COX1
and
COX2
, with
IC
50
s of 18 nM and 26 nM for human COX-1 and COX-2, respectively, in CHO cells. Indomethacin inhibits lipopolysaccharide (LPS)-induced PGE2 production (COX-2) in a human whole blood assay with a potency (IC
50
=0.68±0.17 μM), and suppresses coagulation-induced TXB2 production (COX-1) (IC
50
=0.19±0.02 μM). Indomethacin blocks COX-1 with an IC
50
of 20±1 nM in U937 cell microsomes at a low arachidonic acid concentration (0.1 μM).
Indomethacin dose-dependently inhibits both the carrageenan-induced rat paw oedema (ED
50
, 2.0 mg/kg), hyperalgesia (ED
50
, 1.5 mg/kg), and is also effective at reversing LPS-induced pyrexia in rats (ED
50
, 1.1 mg/kg). Indomethacin (2.5 mg/kg, i.p) decreases the number of NeuN
+
cells in the animals at 8 days after ET-1 injection. Indomethacin also reduces microglia/macrophage activation at 14 days. Indomethacin significantly increases the number of SVZ DCX
+
cells/field at 14 days post stroke. Indomethacin (22.9 mg/kg, p.o.) produces 8 to 10 linear mucosal lesions extended from the fundic to pyloric area of stomach wall.
吲哚美辛钠
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/01/25 | HY-14397A | 吲哚美辛钠
Indomethacin sodium hydrate | 74252-25-8 | 500mg | 350元 |
| 2024/01/25 | HY-14397A | 吲哚美辛钠
Indomethacin sodium hydrate | 74252-25-8 | 1g | 450元 |
74252-25-8, 吲哚美辛钠 相关搜索:
- 请选择 -请选择
- 化学试剂
- 医用原料
- 原料
- 日用化学品
- 原料药
- 兽药原料药
- 医用原料
- 化工原料
- 医药兽药
- 化合物：原料药
- 解热镇痛药
- 饲料添加剂
- 兽药
- C19H21ClNNaO7
- 吲哚美锌钠
- 吲哚美辛钠盐三水合物
- 水溶性吲哚美辛
- 吲哚美辛钠中文名称:吲哚美辛钠中文同义词:吲哚美辛钠
- INDOMETHACIN SODIUM SALT TRIHYDRATE英文同义词:SODIUM,2-[1-(4-CHLOROBENZOYL)-5-METHOXY-2-METHYLINDOL-3-YL]ACETATE,TRIHYDRATE
- 吲哚美辛钠 水溶性
- 2-甲基-1-(4-氯苯甲酰基)-5-甲氧基-1H-吲哚-3-乙酸钠
- 吲哚美辛钠
- 74252-25-8
- Indomethacin sodium trihydrate
- Indomethacin sodium salt 3-hydrate
- Indomethacin sodium hydrate
- sodium,2-[1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetate,trihydrate
- Sodium salt trihydrate
- Indometacin Sodium
- 1H-Indole-3-aceticacid, 1-(4-chlorobenzoyl)-5-Methoxy-2-Methyl-, sodiuM salt, hydrate (1:1:3)
- INDOMETACIN FARNESIL
- 1H-Indole-3-acetic acid, 1-(4-chlorobenzoyl)-5-methoxy-2-methyl-, sodi um salt, trihydrate
- INDOMETHACIN SODIUM SALT TRIHYDRATE