6-[4-(叔丁基)苯氧基]吡啶-3-胺
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- CAS号:
- 218457-67-1
- 英文名:
- 5-AMINO-2-(4-TERT-BUTYLPHENOXY)PYRIDINE
- 英文别名:
- BUTTPARK 96\12-100;6-(4-tert-butylphenoxy)-3-pyridinamine;5-AMINO-2-(4-TERT-BUTYLPHENOXY)PYRIDINE;6-[4-(TERT-BUTYL)PHENOXY]PYRIDIN-3-AMINE;6-[4-(tert-Butyl)phenoxy]pyridin-3-amine97%;6-[4-(tert-Butyl)phenoxy]pyridin-3-amine 97%;6-[4-(1,1-Dimethylethyl)phenoxy]-3-pyridinamine;3-Pyridinamine, 6-[4-(1,1-dimethylethyl)phenoxy]-;pathway,CB103,inhibit,Inhibitor,Notch,CB-103,signaling,leukemia,CB 103
- 中文名:
- 6-[4-(叔丁基)苯氧基]吡啶-3-胺
- 中文别名:
- 5-氨基-2-(4-叔丁苯氧基)吡啶;6-[4-(叔丁基)苯氧基]吡啶-3-胺;6-[4-(叔丁基)苯氧基]吡啶-3-胺;6-[4-(叔丁基)苯氧基]吡啶-3-胺6-(4-(TERT-BUTYL)PHENOXY)PYRIDIN-3-AMINE;6-[4-(叔丁基)苯氧基]吡啶-3-胺
6-(4-(tert-Butyl)phenoxy)pyridin-3-amine
- CBNumber:
- CB8254830
- 分子式:
- C15H18N2O
- 分子量:
- 242.32
- MOL File:
- 218457-67-1.mol
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6-[4-(叔丁基)苯氧基]吡啶-3-胺化学性质
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熔点:
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89-90
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储存条件:
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2-8°C
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溶解度:
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Soluble in DMSO (>30 mg/ml)
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形态:
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solid
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颜色:
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Off-white to pale orange
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稳定性:
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Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
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CAS 数据库:
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218457-67-1(CAS DataBase Reference)
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6-[4-(叔丁基)苯氧基]吡啶-3-胺性质、用途与生产工艺
CB-103 是一种口服活性的 Notch 转录激活复合物的抑制剂。CB-103 可在果蝇和小鼠中产生Notch功能丧失的表型,并抑制人类乳腺癌和白血病异种移植瘤的生长。
CB-103 acts as a pan-NOTCH inhibitor by targeting NOTCH transcriptional activation complex.
CB-103 has shown the ability to block NOTCH signaling in human T cell acute lymphoblastic leukemia cancer cell lines.
CB-103 exhibits anti-tumor efficacy in GSI resistant T-ALL cell lines.
Cell Viability Assay
Cell Line:
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RPMI 8402, KOPTK1, PANC1, nRas driven melanoma cells
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Concentration:
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10 μM
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Incubation Time:
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4 days, 6 days
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Result:
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Caused a significant reduction in their growth potential.
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CB-103 inhibits NOTCH dependent cellular processes in mice.
CB-103 blocks in vivo growth of PDX models of T-ALL.
CB-103 (25 mg/kg; i.p./p.o.; 2x daily; for 2 weeks) inhibits growth of GSI/Mab resistant triple negative breast cancer.
CB-103 exhibits anti-tumor activity in xenograft models of human T-ALL and mouse mammary tumors.
Animal Model:
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NSG mice, triple negative breast cancer mouse xenograft model
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Dosage:
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25 mg/kg
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Administration:
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Oral administration/Intraperitoneal injection; 2x daily; for 2 weeks
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Result:
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Inhibited growth of GSI/Mab resistant triple negative breast cancer.
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6-[4-(叔丁基)苯氧基]吡啶-3-胺
上下游产品信息
上游原料
下游产品
更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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2024/01/16 | S9719 | 6-[4-(叔丁基)苯氧基]吡啶-3-胺 CB-103 | 218457-67-1 | 5mg | 713.16元 |
2024/01/16 | S9719 | CB-103 | 218457-67-1 | 10mM (1mL in DMSO) | 794.43元 |
6-[4-(叔丁基)苯氧基]吡啶-3-胺
生产厂家
218457-67-1, 6-[4-(叔丁基)苯氧基]吡啶-3-胺 相关搜索:
- 合成有机化合物配体
- 抑制剂
- 合成中间体
- ARYL AMINE
- C15H18N2O
- 6-[4-(叔丁基)苯氧基]吡啶-3-胺6-(4-(TERT-BUTYL)PHENOXY)PYRIDIN-3-AMINE
- 6-[4-(叔丁基)苯氧基]吡啶-3-胺
6-(4-(tert-Butyl)phenoxy)pyridin-3-amine
- 6-[4-(叔丁基)苯氧基]吡啶-3-胺
- 5-氨基-2-(4-叔丁苯氧基)吡啶
- 6-[4-(叔丁基)苯氧基]吡啶-3-胺
- 218457-67-1
- 6-[4-(1,1-Dimethylethyl)phenoxy]-3-pyridinamine
- pathway,CB103,inhibit,Inhibitor,Notch,CB-103,signaling,leukemia,CB 103
- 6-(4-tert-butylphenoxy)-3-pyridinamine
- 3-Pyridinamine, 6-[4-(1,1-dimethylethyl)phenoxy]-
- BUTTPARK 96\12-100
- 6-[4-(TERT-BUTYL)PHENOXY]PYRIDIN-3-AMINE
- 5-AMINO-2-(4-TERT-BUTYLPHENOXY)PYRIDINE
- 6-[4-(tert-Butyl)phenoxy]pyridin-3-amine97%
- 6-[4-(tert-Butyl)phenoxy]pyridin-3-amine 97%