那可汀
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- CAS号:
- 128-62-1
- 英文名:
- Narcotine
- 英文别名:
- Opian;Capval;Lyobex;Ecasil;Terial;Vadebe;Nipaxon;Detusso;nsc5366;Opianin
- 中文名:
- 那可汀
- 中文别名:
- 鼻瓣;那可汀;纳可丁;诺司卡品;诺斯卡品;那可汀[鹼];罂粟碱EP杂质A;那可汀 EP标准品;(S,R)-那可汀;那可丁 USP标准品
- CBNumber:
- CB8468501
- 分子式:
- C22H23NO7
- 分子量:
- 413.42
- MOL File:
- 128-62-1.mol
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那可汀化学性质
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熔点:
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174-176 °C(lit.)
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比旋光度:
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-200 º (c=1 in chloroform)
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沸点:
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532.6°C (rough estimate)
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密度:
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1.395
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折射率:
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1.5614 (estimate)
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储存条件:
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-20°C Freezer, Under Inert Atmosphere
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溶解度:
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Practically insoluble in water, soluble in acetone, slightly soluble in ethanol (96 per cent). It dissolves in strong acids; on dilution of the solution with water, the base may be precipitated.
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酸度系数(pKa):
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7.8(at 25℃)
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颜色:
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Orthorhombic prisms or stout needles from alc
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旋光性 (optical activity):
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[α]20/D 200°, c = 1 in chloroform
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水溶解性:
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302.9mg/L(25 ºC)
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Merck:
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13,6752
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NIST化学物质信息:
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Narcotine alkaloid(128-62-1)
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EPA化学物质信息:
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1(3H)-Isobenzofuranone, 6,7-dimethoxy-3-[(5R)-5,6,7,8-tetrahydro-4-methoxy-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl]-, (3S)- (128-62-1)
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那可汀性质、用途与生产工艺
Noscapine ((S,R)-Noscapine) 是一种具有口服活性的苯酞异喹啉生物碱，具有强效镇咳作用。Noscapine 通过激活 sigma 阿片类受体 (sigma opioid receptors) 发挥镇咳作用，是一种非竞争性 Bradykinin 抑制剂。Noscapine 破坏微管动力学，诱导细胞有丝分裂停滞和凋亡 (apoptosis) 以及活性。Noscapine 具有抗癌，神经保护，抗炎活性，并且可以穿越血脑屏障。
Sigma opioid receptors
Bradykinin
Apoptosis
Noscapine (0-1000 μM; 0-96 hours; rat C6 glioma cells) treatment inhibits cell viability of rat C6 glioma in vitro in a dose- and time-dependent manner. Noscapine inhibits the viability of rat C6 glioma cells with an IC
50
of 250 μM at 72 hours.
Noscapine exposure causes abnormal S-phase reentry, increases mitotic arrest and results in excessive DNA accumulation.
Cylindromatosis increases the ability of noscapine to induce mitotic arrest and apoptosis. Cylindromatosis enhances the effect of noscapine on microtubule polymerization and promotes noscapine binding to microtubules.
Cell Viability Assay
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Cell Line:
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Rat C6 glioma cells
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Concentration:
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0 μM, 0.1 μM, 1 μM, 2 μM, 10 μM, 50 μM, 100 μM, 1000 μM
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Incubation Time:
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0 hours, 12 hours, 24 hours, 48 hours, 72 hours, 96 hours
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Result:
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Inhibited cell viability of rat C6 glioma in vitro in a dose- and time-dependent manner.
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Noscapine (300 mg/kg; oral gavage; daily; for 15 days; athymic female mice) treatment reduces tumor growth in mice.
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Animal Model:
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Athymic female mice (nu/nu) (8-week-old) injected with rat C6 glioma cells
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Dosage:
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300 mg/kg
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Administration:
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Oral gavage; daily; for 15 days
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Result:
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Revealed a significant reduction of tumor volume.
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化学性质
无色结晶性粉末或有光泽的棱柱状或片状结晶；无臭，无味。几乎不溶于水，微溶于乙醇与乙醚，溶于氯仿。
用途
支气管解痉性镇咳药。
那可汀
上下游产品信息
上游原料
下游产品
5,6,7,8-四氢-4-甲氧基-6-甲基-1,3-1,3-二氧杂环戊基(4,5-G)异喹啉-5-醇
[S-(R*,S*)]-3,4-dimethoxy-alpha1-(5,6,7,8-tetrahydro-4-methoxy-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl)-o-xylene-alpha,alpha'-diol
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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| 2024/01/16 | XW12862102 | 试剂Noscapine
Narcotine | | 250mg | 1024元 |
| 2024/01/16 | XW12862101 | 试剂Noscapine
Narcotine | | 50mg | 273元 |
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128-62-1, 那可汀 相关搜索:
- FINACEAE
- Complex Molecules
- Chiral Building Blocks
- Asymmetric Synthesis
- Pharmaceuticals
- Intermediates & Fine Chemicals
- 医药原料药
- 化工原料
- 标准品
- 镇咳药物
- Complex Molecules
- Chiral Building Blocks
- Asymmetric Synthesis
- C22H23NO7
- 22H23NO7
- 鼻瓣
- 罂粟碱EP杂质A
- 诺斯卡品-13C-D3
- 乙腈中那可汀溶液,100ΜG/ML
- 那可汀 EP标准品
- NOSCAPINE[干冰运输]
- (-)-NOSCAPINE
- 那可丁 USP标准品
- 诺斯卡品
- 那可汀[鹼]
- 纳可丁
- (S,R)-那可汀
- 诺司卡品
- (S,R)-诺司卡品
- 那可汀
- 128-62-1
- Noscapine (1474504)
- Narcotine Solution in Acetonitrile, 100μg/mL
- 1(3H)-Isobenzofuranone, 6,7-dimethoxy-3-[(5R)-5,6,7,8-tetrahydro-4-methoxy-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl]-, (3S)-
- Noscapine CRS
- NOSCAPINE BP
- 7-O-Demethyl &alpha
- Noscapine(HSDB 3372,NSC5366)
- alpha-Narcotine
- 6,7-dimethoxy-3-(5,6,7,8-tetrahydro-4-methoxy-6-methyl-1(3h)-isobenzofuranon
- NOSCAPINE (NARCOTINE) NATURALLY OCCURRIN G O
- NARCOTINE
- NOSCAPINE
- (S)-6,7-DIMETHOXY-3-((R)-4-METHOXY-6-METHYL-5,6,7,8-TETRAHYDRO-[1,3]DIOXOLO[4,5-G]ISOQUINOLIN-5-YL)-3H-ISOBENZOFURAN-1-ONE
- (S,R)-NOSCAPINE
- S(R*,S*)-6,7-DIMETHOXY-3-(5,6,7,8-TETRAHYDRO-4-METHOXY-6-METHYL-1,3-DIOXOLO[4,5-G]-ISOQUINOLIN-5-YL)-1(3H)-ISOBENZOFURANONE
- L-ALPHA-NARCOTINE
- 1,3-Dioxolo[4,5-g]isoquinoline, 1(3H)-isobenzofuranone deriv.
- 1(3H)-Isobenzofuranone, 6,7-dimethoxy-3-[(5R)-5,6,7,8-tetrahydro-4-methoxy-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl]-, (3S)- (9CI)
- Vadebe
- a-Narcotine
- (3S)-6,7-Dimethoxy-3-[(5R)-5,6,7,8-tetrahydro-4-methoxy-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl]-1(3H)-isobenzofuranone
- (-)-a-Narcotine
- Vadebex
- tusseapine
- Tusscapine
- Terbenol
- Phthalide, 6,7-dimethoxy-3-(5,6,7,8-tetrahydro-4-methoxy-6-methyl-1,3-dioxolo(4,5-g)isoquinolin-5-yl)-