氧羰酰-4-羟基苯胺
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- CAS号:
- 54840-15-2
- 英文名:
- 4-N-BOC-AMINOPHENOL
- 英文别名:
- 4-N-BOC-AMINOPHENOL;4-(BOC-AMINO)PHENOL;N-BOC-4-HYDROXY ANILINE;N-Boc-4-hydroxyaniline 97%;N-Boc-4-hydroxyaniline,95%;N-Boc-4-hydroxyaniline;tert-Butyl p-hydroxycarbanilate;tert-butyl 4-hydroxyphenylcarbamate;tert-Butyl N-(4-hydroxyphenyl)carbamate;1,1-DiMethylethyl (4-hydroxyphenyl)carbaMate
- 中文名:
- 氧羰酰-4-羟基苯胺
- 中文别名:
- 氧羰酰-4-羟基苯胺;4-(BOC-氨基)酚;N-BOC-4-羟基苯胺;4-(BOC-氨基)苯酚;N-BOC-4-氨基苯酚;4-羟基苯基氨基甲酸叔丁酯
- CBNumber:
- CB9246409
- 分子式:
- C11H15NO3
- 分子量:
- 209.24
- MOL File:
- 54840-15-2.mol
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氧羰酰-4-羟基苯胺化学性质
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熔点:
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143-147 °C(lit.)
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沸点:
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288.7±23.0 °C(Predicted)
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密度:
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1.182±0.06 g/cm3(Predicted)
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储存条件:
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Keep in dark place,Sealed in dry,Room Temperature
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酸度系数(pKa):
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10.13±0.26(Predicted)
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外观:
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White to off-white Solid
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水溶解性:
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Slightly soluble in water.
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InChI:
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InChI=1S/C11H15NO3/c1-11(2,3)15-10(14)12-8-4-6-9(13)7-5-8/h4-7,13H,1-3H3,(H,12,14)
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InChIKey:
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YRQMBQUMJFVZLF-UHFFFAOYSA-N
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SMILES:
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C(OC(C)(C)C)(=O)NC1=CC=C(O)C=C1
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CAS 数据库:
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54840-15-2(CAS DataBase Reference)
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氧羰酰-4-羟基苯胺性质、用途与生产工艺
生产方法
以二碳酸二叔丁酯和4-氨基苯酚为原料合成氧羰酰-4-羟基苯胺的一般步骤：向含有4-氨基苯酚（10.97g，100.5mmol）和三乙胺（30mL）的甲醇（200mL）溶液中缓慢加入二碳酸二叔丁酯（24.07g，110.3mmol）。反应混合物在室温（22℃）下搅拌反应14小时。反应完成后，通过旋转蒸发除去溶剂。将残余物溶解于乙酸乙酯（250mL）中，并用0.25N盐酸水溶液（100mL）进行萃取。分离有机相，依次用饱和氯化铵水溶液（3×50mL）洗涤，无水硫酸钠干燥。最后，通过旋转蒸发除去溶剂，得到白色固体产物氧羰酰-4-羟基苯胺（20.91g，收率100%，ESI-MS（m/z）208.1 [M-H]-）。
参考文献：
[1] Patent: EP1609789, 2005, A1. Location in patent: Page/Page column 12
[2] Tetrahedron Letters, 2011, vol. 52, # 12, p. 1260 - 1264
[3] Chemical Communications, 2013, vol. 49, # 51, p. 5757 - 5759
[4] Organic Letters, 2016, vol. 18, # 21, p. 5728 - 5731
[5] Comptes Rendus Chimie, 2013, vol. 16, # 11, p. 962 - 966
氧羰酰-4-羟基苯胺
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2025/05/22 | H55645 | 4-(Boc-氨基)苯酚, 97%
4-(Boc-amino)phenol, 97% | 54840-15-2 | 5g | 689元 |
| 2025/05/22 | H55645 | 4-(Boc-氨基)苯酚, 97%
4-(Boc-amino)phenol, 97% | 54840-15-2 | 25g | 2407元 |
氧羰酰-4-羟基苯胺
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54840-15-2, 氧羰酰-4-羟基苯胺 相关搜索:
- N-BOC
- 高端化学
- Amino Alcohols
- Building Blocks
- Organic Building Blocks
- Oxygen Compounds
- C11H15NO3
- N-BOC-4-羟基苯胺
- 4-(BOC-氨基)苯酚
- 氧羰酰-4-羟基苯胺
- 4-(BOC-氨基)酚
- N-BOC-4-氨基苯酚
- 4-羟基苯基氨基甲酸叔丁酯
- 54840-15-2
- N-Boc-4-hydroxyaniline
- N-Boc-4-hydroxyaniline,95%
- Carbamic acid, N-(4-hydroxyphenyl)-, 1,1-dimethylethyl ester
- N-Boc-4-hydroxyaniline 97%
- tert-Butyl p-hydroxycarbanilate
- tert-Butyl N-(4-hydroxyphenyl)carbamate
- 1,1-DiMethylethyl (4-hydroxyphenyl)carbaMate
- tert-butyl 4-hydroxyphenylcarbamate
- Carbamic acid, (4-hydroxyphenyl)-, 1,1-dimethylethyl ester (9CI)
- (4-HYDROXY-PHENYL)-CARBAMIC ACID TERT-BUTYL ESTER
- 4-N-BOC-AMINOPHENOL
- 4-(BOC-AMINO)PHENOL
- N-BOC-4-HYDROXY ANILINE