(S)-(-)-3-BOC-4-甲氧羰基-2,2-二甲基-1,3-恶唑烷

(S)-(-)-3-BOC-4-甲氧羰基-2,2-二甲基-1,3-恶唑烷性质、用途与生产工艺

用途

制备

以乙醇胺、丙酮及二碳酸二叔丁酯为起始物料，经一锅法反应制备得到目标化合物(S)-(-)-3-BOC-4-甲氧羰基-2,2-二甲基-1,3-恶唑烷。其合成反应式如下图：

实验步骤

在100ml干燥的三径圆底烧瓶上分别装置温度计、滴液漏斗和冷凝管，依次加入乙醇胺、丙酮和苯，在35℃下搅拌30分钟.。将反应体系用冰盐浴冷却至-10℃，加入氢氧化钠水溶液后搅拌，当反应温度下降至-5℃时，慢慢滴加二碳酸二叔丁酯，控制体系温度为0℃，约40分钟滴加完毕，继续搅拌1小时。将反应液水洗至中性，用无水硫酸镁干燥，蒸出溶剂，固体用乙酸乙酯 / 石油醚重结晶，得产品(S)-(-)-3-BOC-4-甲氧羰基-2,2-二甲基-1,3-恶唑烷。

(S)-(-)-3-BOC-4-甲氧羰基-2,2-二甲基-1,3-恶唑烷 上下游产品信息

上游原料

下游产品

(S)-(-)-3-BOC-4-甲氧羰基-2,2-二甲基-1,3-恶唑烷 生产厂家

108149-60-6, (S)-(-)-3-BOC-4-甲氧羰基-2,2-二甲基-1,3-恶唑烷 相关搜索:

• Synthetic Organic Chemistry
• Esters (Chiral)
• Chiral Building Blocks
• 高端化学
• 手性砌块
• Oxazolidinone Derivatives
• Chiral Building Blocks
• Esters (Chiral)
• Asymmetric Synthesis
• Chiral Auxiliaries
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• (S)-(-)-3-BOC-4-甲氧羰基-2,2-二甲基-1,3-恶唑烷 1G
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• 108149-60-6
• 3-(tert-butyl) 4-methyl (S)-2,2-dimethyloxazolidine-3,4-dicarboxylate
• (S)-(-)-3-Tert-Butoxycarbonyl-4-Methoxycarbonyl-2,2-Dimethyl...
• (S)-(-)-3-tert-Butoxycarbonyl-4-methoxycarbonyl-2,2-dimethyl-1,3-oxazolidine >
• (S)-(-)-3-tert-Butoxycarbonyl-4-methoxycarbonyl-2,2-dimethyl-1,3-oxazolidine, 98%, ee: 98%
• 3-O-tert-butyl 4-O-methyl (4S)-2,2-dimethyl-1,3-oxazolidine-3,4-dicarboxylate
• 3-tert-Butyl 4-methyl (4S)-2,2-dimethyl-1,3-oxazolidine-3,4-dicarboxylate 98%
• Methyl (S)-(-)3-BOC-2,2-dimethyl-4-oxazolidinecarboxylate,93%,tech.
• Methyl (4S)-3-(tert-butoxycarbonyl)-2,2-dimethyloxazolidine-4-carboxylate
• Methyl-(S)-3-(tert-butoxycarbonyl)-2,2-dimethyl-4-oxazolidinecarboxylate, tech.
• METHYL-(S)-3-(TERT.-BUTOXYCARBONYL)-2,2-DIMETHYL-4-OXAZOLIDINECARBOXYLATE, TECH.,93%
• methyl (tert-butoxycarbonyl)dimethyloxazolidinecarboxylate
• 3-(1,1-dimethylethyl)-4-methyl-(S)-2,2-dimethyl-3,4-oxazolidinedicarboxylate, 98 %
• TERT-BUTYL METHYL (4S)-2,2-DIMETHYLOXAZOLIDINE-3,4-DICARBOXYLATE
• (S)-(-)-3-tert-Butoxycarbonyl-4-methoxycarbonyl-
• methyl (s)-(-)-3-boc-2,2-dimethyl-4-oxazolidinecarboxylate
• methyl(s)-3-(t-butoxycarbonyl)-2,2-di-me-4-oxazolidinecarboxylate(ee)
• Methyl (S)-(-)-3-Boc-2,2-dimethyl-4-oxazolidinecarboxylate, 98% (99% ee)
• (S)-(-)-3-tert-Butoxycarbonyl-4-Methoxycarbonyl-2,2-diMethyl-1,3-oxazolidine, ee: 98%
• Methyl (S)-N-Boc-2,2-diMethyloxazolidine-4-carboxylate
• (S)-(-)-3-Boc-4-methoxycarbonyl-2,2-dimethyl-1,3-oxazolidine Methyl (S)-(-)-3-tert-Butoxycarbonyl-2,2-dimethyl-4-oxazolidinecarboxylate
• 3-(1,1-Dimethylethyl)-4-methyl-(S)-2,2-dimethyl-3,4-oxazolidinedicarboxylate mainly S
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• Methyl (S)-(-)3-BOC-2,2-dimethyl-4-oxazolidinecarboxylate, tech., 93%
• (S)-3-Boc-2,2-dimethyl-oxazolidine-4-carboxylicacid methyl ester
• BOC-2,2-DIMETHYLOXAZOLIDINE-4-CARBOXYLIC ACID METHYL ESTER
• METHYL (S)-3-(TERT-BUTOXYCARBONYL)-2,2-DIMETHYL-4-OXAZOLIDINECARBOXYLATE
• METHYL (S)-(-)-3-TERT-BUTOXYCARBONYL-2,2-DIMETHYL-4-OXAZOLIDINECARBOXYLATE
• METHYL 3-(TERT-BUTOXYCARBONYL)-2, 2-DIMETHYL-4-OXAZOLIDINECARBOXYLATE
• (S)-2,2-Dimethyloxazolidine-3,4-dicarboxylic acid 3-tert-butyl ester 4-methyl ester
• (S)-3-tert-butyl4-methyl2,2-dimethyloxazolidine-3,4-dicarboxylate
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