MG-115

MG-115 Struktur
133407-86-0
CAS-Nr.
133407-86-0
Englisch Name:
MG-115
Synonyma:
MG-115;Z-LLnV;(S)-MG115;Z-LL-NVA-CHO;MG115, Z-LLnV;Z-LEU-LEU-NVA-H;Z-LEU-LEU-NVA-CHO;z-leu-leu-norvalinal;Z-LEU-LEU-NVA-ALDEHYDE;MG-115 (DMSO solution)
CBNumber:
CB0195607
Summenformel:
C25H39N3O5
Molgewicht:
461.59
MOL-Datei:
133407-86-0.mol

MG-115 Eigenschaften

Siedepunkt:
678.8±55.0 °C(Predicted)
Dichte
1.082±0.06 g/cm3(Predicted)
storage temp. 
-20°C
Löslichkeit
DMSO: soluble
Aggregatzustand
powder
pka
11.14±0.46(Predicted)
Farbe
white

Sicherheit

WGK Germany  3

MG-115 Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

(S)-MG115 is a potent and reversible proteasome inhibitor, targeting the chymotryptic site on the 20S particle (Ki = 21 nM). It reduces the degradation of ubiquitin-conjugated proteins in extracts. (S)-MG115 also blocks the degradation of long- and short-lived proteins in intact cells as well as the proteolytic generation of diverse proteins, including NF-κB, antigens, and p53. Proteasome inhibitors, including (S)-MG115, can induce a heat shock response and apoptosis, particularly in cancer cells.

Verwenden

MG-115 is a compound that inhibits the chymotrypsin-like activity of the proteasome.

Allgemeine Beschreibung

Potent reversible proteasome inhibitor (Ki = 21 nM and 35 nM for 20S and 26S proteasome, respectively).

MG-115 Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


MG-115 Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 86)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Alpha Biopharmaceuticals Co., Ltd
+86-411-39042497 +8613921981412
sales@alphabiopharm.com China 886 58
ATK CHEMICAL COMPANY LIMITED
+undefined-21-51877795
ivan@atkchemical.com China 32480 60
Nextpeptide Inc
+86-0571-81612335 +8613336028439
sales@nextpeptide.com China 19915 58
Nantong HI-FUTURE Biology Co., Ltd.
+undefined18051384581
sales@chemhifuture.com China 3136 58
ZHEJIANG JIUZHOU CHEM CO., LTD
+86-0576225566889 +86-13454675544
admin@jiuzhou-chem.com;jamie@jiuzhou-chem.com;alice@jiuzhou-chem.com China 20000 58
Aladdin Scientific
+1-833-552-7181
sales@aladdinsci.com United States 57511 58
Aladdin Scientific
+1-833-552-7181
sales@aladdinsci.com United States 52927 58
Alabiochem Tech.Co., Ltd. 0512-58900862 400-0707518
sales@alabiochem.com China 995 59
Guangzhou Isun Pharmaceutical Co., Ltd 020-39119399 18927568969
isunpharm@qq.com China 4428 55
ApexBio Technology LLC +1-832-696-8203
info@apexbt.com United States 477 60

133407-86-0()Verwandte Suche:


  • PROTEASOME INHIBITOR MG-115
  • N-CBZ-LEU-LEU-NORVALINAL
  • MG-115
  • Z-LL-NVA-CHO
  • Z-LEU-LEU-NVA-ALDEHYDE
  • Z-LEU-LEU-NVA-CHO
  • Z-LEU-LEU-NVA-H
  • Z-LEU-LEU-NVA-H (ALDEHYDE)
  • CARBOBENZOXY-L-LEUCYL-L-LEUCYL-L-NORVALINAL
  • CARBOBENZOXY-L-LEUCYL-L-LEUCYL-NORVALINAL
  • BENZYLOXYCARBONYL-L-LEUCYL-L-LEUCYL-L-NORVALINAL
  • z-leu-leu-norvalinal
  • N-carbobenzyloxy-Leu-Leu-norvalinal
  • MG115, Z-LLnV
  • Z-Leu-Leu-Norvalinal,MG115, Z-LLnV
  • (S)-MG115
  • Z-LLnV
  • L-Leucinamide, N-[(phenylmethoxy)carbonyl]-L-leucyl-N-[(1S)-1-formylbutyl]-
  • MG-115 - CAS 133407-86-0 - Calbiochem
  • MG-115 (DMSO solution)
  • 133407-86-0
  • C25H39N3O5
  • Inhibitors
  • BioChemical
  • Biochemicals and Reagents
  • Application Index
  • Cell Signaling Enzymes
  • Proteasome, Calpain and Lysosomal Proteases
  • Proteasomes
  • Enzymes, Inhibitors, and Substrates
  • Calpain and Lysosomal Proteases
  • Proteasome Inhibitors
  • Aldehydes
  • and Substrates
  • Application Index
  • Bioactive Small Molecules
  • Biochemicals and Reagents
  • Building Blocks
  • C13-C60
  • Calpain and Proteasome Inhibitors
  • Carbonyl Compounds
  • Cell Biology
  • Cell Signaling and Neuroscience
  • Cell Signaling Enzymes
  • Chemical Synthesis
  • Endoplasmic Reticulum Stress
  • Enzymes
  • Inhibitors
  • Intracellular Protein Degradation
  • Nitric Oxide and Cell Stress
  • Organic Building Blocks
  • Proteasome
  • Proteasomes
  • Z
  • ProteasomeInhibitors
  • peptides
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