MRK 560

677772-84-8

CAS-Nr.: 677772-84-8

Englisch Name:: MRK 560

Synonyma:: MRK 560;MRK-560; MRK560;WDZVWDXOIGQJIO-UJKQEGAGSA-N;N-[cis-4-[(4-Chlorophenyl)sulfonyl]-4-(2,5-difluorophenyl)cyclohexyl]-1,1,1-trifluoromethanesulfonamide;Methanesulfonamide, N-[cis-4-[(4-chlorophenyl)sulfonyl]-4-(2,5-difluorophenyl)cyclohexyl]-1,1,1-trifluoro-;N-((1s,4s)-4-((4-chlorophenyl)sulfonyl)-4-(2,5-difluorophenyl)cyclohexyl)-1,1,1-trifluoromethanesulfonamide;MRK-560,Jurkat cells,DND-41,Aβ peptides,MRK560,MRK 560,Gamma secretase,γ-secretase,T-ALL,Inhibitor,inhibit,Alzheimer’s disease,HPB-ALL

CBNumber:: CB02538282

Summenformel:: C19H17ClF5NO4S2

Molgewicht:: 517.92

MOL-Datei:: 677772-84-8.mol

Request For Quotation

Eigenschaften Sicherheit Verwendungswort Produktionsfirma 37

MRK 560 Eigenschaften

Siedepunkt:: 580.1±60.0 °C(Predicted)

Dichte: 1.57±0.1 g/cm3(Predicted)

storage temp.: Store at 4°C

Löslichkeit: <51.79mg/ml in DMSO; <25.9mg/ml in ethanol

Aggregatzustand: solid

pka: 5.97±0.40(Predicted)

Farbe: White

Sicherheit

MRK 560 Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

MRK-560 is a potent inhibitor of γ-secretase (IC₅₀ = 0.65 nM). In vivo, MRK-560 (1-10 mg/kg) reduces diethanolamine-soluble amyloid-β (1-40) (Aβ40) levels in APP-YAC transgenic mouse brain. MRK-560 reduces brain and cerebrospinal fluid Aβ40 levels in rats (ED₅₀s = 6 and 10 mg/kg, respectively). It also decreases brain-soluble Aβ40 and Aβ42 levels and recovers hippocampal long-term potentiation in the Tg2576 transgenic mouse model of Alzheimer''s disease.

Verwenden

MRK 560 acts as a y-secretase inhibitor that is orally bioavailable and potent and may be used in a therapeutic strategy to counter low amyloid (β) production in Alheimer’s disease.

MRK 560 Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

MRK 560 Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 37)Lieferanten

Firmenname	Telefon	E-Mail	Land	Produktkatalog	Edge Rate
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	19892	58
Wuhan Topule Biopharmaceutical Co., Ltd	+8618327326525	masar@topule.com	China	8474	58
Aladdin Scientific	+1-833-552-7181	sales@aladdinsci.com	United States	57511	58
ShangHai Caerulum Pharma Discovery Co., Ltd.	18149758185	sales-cpd@caerulumpharma.com	China	3421	58
Shanghai Beckham Medical Technology Co., Ltd	021-13816613772 13816613772	huahero21@sina.com	China	357	55
EMMX Biotechnology LLC	888-539-0666	info@emmx.com	United States	8449	60
ShangHai Biochempartner Co.,Ltd	17754423994 17754423994	2853530910@QQ.com	China	8011	62
Shanghai Rechem science Co., Ltd.	21-31433387 15618786686	sales@rechemscience.com	China	2981	58
Shanghai zhigan biotechnology co., LTD		zhiqianbio@126.com	China	19785	58
ChemeGen(Shanghai) Biotechnology Co.,Ltd.	18818260767	sales@chemegen.com	China	11289	58

N-[cis-4-[(4-Chlorophenyl)sulfonyl]-4-(2,5-difluorophenyl)cyclohexyl]-1,1,1-trifluoromethanesulfonamide
N-((1s,4s)-4-((4-chlorophenyl)sulfonyl)-4-(2,5-difluorophenyl)cyclohexyl)-1,1,1-trifluoromethanesulfonamide
MRK 560
Methanesulfonamide, N-[cis-4-[(4-chlorophenyl)sulfonyl]-4-(2,5-difluorophenyl)cyclohexyl]-1,1,1-trifluoro-
MRK-560; MRK560
WDZVWDXOIGQJIO-UJKQEGAGSA-N
MRK-560,Jurkat cells,DND-41,Aβ peptides,MRK560,MRK 560,Gamma secretase,γ-secretase,T-ALL,Inhibitor,inhibit,Alzheimer’s disease,HPB-ALL
677772-84-8
C19H17ClF5NO4S2