MRK 560
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MRK 560 속성
- 끓는 점
- 580.1±60.0 °C(Predicted)
- 밀도
- 1.57±0.1 g/cm3(Predicted)
- 저장 조건
- Store at 4°C
- 용해도
- <51.79mg/ml in DMSO; <25.9mg/ml in ethanol
- 물리적 상태
- 고체
- 물리적 상태
- 단단한 모양
- 산도 계수 (pKa)
- 5.97±0.40(Predicted)
- 색상
- 하얀색
안전
MRK 560 C화학적 특성, 용도, 생산
개요
MRK-560 is a potent inhibitor of γ-secretase (IC50 = 0.65 nM). In vivo, MRK-560 (1-10 mg/kg) reduces diethanolamine-soluble amyloid-β (1-40) (Aβ40) levels in APP-YAC transgenic mouse brain. MRK-560 reduces brain and cerebrospinal fluid Aβ40 levels in rats (ED50s = 6 and 10 mg/kg, respectively). It also decreases brain-soluble Aβ40 and Aβ42 levels and recovers hippocampal long-term potentiation in the Tg2576 transgenic mouse model of Alzheimer''s disease.용도
MRK 560 acts as a y-secretase inhibitor that is orally bioavailable and potent and may be used in a therapeutic strategy to counter low amyloid (β) production in Alheimer’s disease.MRK 560 준비 용품 및 원자재
원자재
준비 용품
MRK 560 공급 업체
글로벌( 39)공급 업체
| 공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 |
marketing@targetmol.com | United States | 19892 | 58 |
| Wuhan Topule Biopharmaceutical Co., Ltd | +8618327326525 |
masar@topule.com | China | 8474 | 58 |
| Aladdin Scientific | +1-+1(833)-552-7181 |
sales@aladdinsci.com | United States | 57511 | 58 |
| ShangHai Caerulum Pharma Discovery Co., Ltd. | 18149758185 |
sales-cpd@caerulumpharma.com | China | 3466 | 58 |
| Shanghai Beckham Medical Technology Co., Ltd | 021-13816613772 13816613772 |
huahero21@sina.com | China | 399 | 55 |
| EMMX Biotechnology LLC | 888-539-0666 |
info@emmx.com | United States | 8449 | 60 |
| ShangHai Biochempartner Co.,Ltd | 17754423994 17754423994 |
2853530910@QQ.com | China | 8014 | 62 |
| Shanghai Rechem science Co., Ltd. | 21-31433387 15618786686 |
sales@rechemscience.com | China | 2992 | 58 |
| Shanghai zhigan biotechnology co., LTD | |
zhiqianbio@126.com | China | 19785 | 58 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 |
sales@chemegen.com | China | 11289 | 58 |