1-[4-(1,2,3,4-TETRAHYDROXYBUTYL)-1H-IMIDAZOL-2-YL]ETHANONE

94944-70-4

CAS-Nr.: 94944-70-4

Englisch Name:: 1-[4-(1,2,3,4-TETRAHYDROXYBUTYL)-1H-IMIDAZOL-2-YL]ETHANONE

Synonyma:: 2-Athbi;Inhibitor,inhibit,2 ATHBI,2ATHBI;2-Acetyl-5-tetrahydroxybutyl Imidazole;2-acetyl-4(5)-tetrahydroxybutylimidazole;2-Acetyl-5-tetrahydroxybutyl iMidazole (THI);2-Acetyl-4-tetrahydroxybutylimidazole Standard;2-Acetyl-4-(1,2,3,4-tetrahydroxybutyl)iMidazole, 97%;2-Acetyl-4-(1,2,3,4-tetrahydroxybutyl)imidazole, 97%,;(R,S,R)-2-Acetyl-4-(1,2,3,4-tetrahydroxybutyl)-imidazole;2-ACETYL-4(5)-(1,2,3,4-TETRAHYDROXYBUTYL)-IMIDAZOLE (THI)

CBNumber:: CB0371535

Summenformel:: C9H14N2O5

Molgewicht:: 230.22

MOL-Datei:: 94944-70-4.mol

Request For Quotation

Eigenschaften Sicherheit Verwendungswort Produktionsfirma 57

1-[4-(1,2,3,4-TETRAHYDROXYBUTYL)-1H-IMIDAZOL-2-YL]ETHANONE Eigenschaften

Schmelzpunkt:: approximate 230℃ (dec.)

Siedepunkt:: 613.5±65.0 °C(Predicted)

Dichte: 1.536±0.06 g/cm3(Predicted)

storage temp.: 2-8°C

Löslichkeit: DMSO: soluble2mg/mL, clear (warmed)

Aggregatzustand: Powder

pka: 10.63±0.10(Predicted)

Farbe: white to light brown

Wasserlöslichkeit: Soluble in distilled water, DMSO (>5 mg/ml), clear (warmed), and PBS pH 7.2 (~0.15 mg/ml).

Stabilität:: Stable for 1 year from date of purchase as supplied. Solutions in distilled water may be stored at -20°C for up to 3 months.

CAS Datenbank: 94944-70-4

Sicherheit

Risiko- und Sicherheitserklärung
Gefahreninformationscode (GHS)

Kennzeichnung gefährlicher	Xn
R-Sätze:	22
WGK Germany	3
HS Code	29332900

Bildanzeige (GHS)

Alarmwort

Warnung

Gefahrenhinweise

Code	Gefahrenhinweise	Gefahrenklasse	Abteilung	Alarmwort	Symbol	P-Code
H302	Gesundheitsschädlich bei Verschlucken.	Akute Toxizität oral	Kategorie 4	Warnung	src="/GHS07.jpg" width="20" height="20" />	P264, P270, P301+P312, P330, P501

Sicherheit

P264	Nach Gebrauch gründlich waschen.
P264	Nach Gebrauch gründlich waschen.
P270	Bei Gebrauch nicht essen, trinken oder rauchen.
P330	Mund ausspülen.

1-[4-(1,2,3,4-TETRAHYDROXYBUTYL)-1H-IMIDAZOL-2-YL]ETHANONE Chemische Eigenschaften,Einsatz,Produktion Methoden

Verwenden

Sphingosine-1-phosphate (S1P) lyase catalyzes the irreversible decomposition of S1P to hexadecanaldehyde and phosphoethanolamine. 2-Acetyl-5-tetrahydroxybutyl imidazole (THI) is an inhibitor of S1P lyase. Because S1P lyase is primarily expressed in lymphatic tissue, treatment of mice with THI (50 μg/ml in drinking water) increases lymphoid tissue S1P concentrations 100-fold, reducing lymphocyte egress from thymus and peripheral lymphoid organs. The resulting lymphopenia is reversible following cessation of THI treatment. Reducing S1P lyase activity results in therapeutic levels of immunosuppression without the non-lymphoid lesions that result from synthetic S1P receptor agonists.

Biochem/physiol Actions

2-Acetyl-5-tetrahydroxybutyl imidazole (THI) can block S1P lyase in vivo and up-regulates circulatory and tissue S1P levels. It has the ability to repress dystrophic muscle degeneration.

1-[4-(1,2,3,4-TETRAHYDROXYBUTYL)-1H-IMIDAZOL-2-YL]ETHANONE Upstream-Materialien And Downstream Produkte

Upstream-Materialien

(3R,4R,5S,6R)-3-amino-6-(hydroxymethyl)tetrahydro-2H-pyran-2,4,5-triol hydrochloride NA 1,3-Dithiolane-2-carboxaldehyde, 2-methyl- 2-?Propenimidic acid, 2-?ethoxy-?, methyl ester 1-Amino-1-deoxy-D-fructose Acetate alpha-Ethoxyacrylonitrile Glucosaminhydrochlorid Methanol

Downstream Produkte

1-[4-(1,2,3,4-TETRAHYDROXYBUTYL)-1H-IMIDAZOL-2-YL]ETHANONE Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 57)Lieferanten

Firmenname	Telefon	E-Mail	Land	Produktkatalog	Edge Rate
BOC Sciences	+1-631-485-4226	inquiry@bocsci.com	United States	19553	58
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	19892	58
Shanghai Acmec Biochemical Technology Co., Ltd.	+undefined18621343501	product@acmec-e.com	China	33349	58
J & K SCIENTIFIC LTD.	010-82848833 400-666-7788	jkinfo@jkchemical.com	China	96815	76
Alfa Aesar	400-6106006	saleschina@alfa-asia.com	China	30132	84
Hangzhou Sage Chemical Co., Ltd.	+86057186818502 13588463833	info@sagechem.com	China	10269	58
Nanjing JinruiJiuAn Biotechnology Co., Ltd.	025-58196018 800028039	sales@fartop.net	China	2231	55
Guangzhou Isun Pharmaceutical Co., Ltd	020-39119399 18927568969	isunpharm@qq.com	China	4428	55
ChemStrong Scientific Co.,Ltd	0755-66853366 13670046396	sales@chem-strong.com	China	17982	56
Shanghai Kewel Chemical Co., Ltd.	021-64609169 18901607656	greensnown@163.com	China	9911	50

1-[4-(1,2,3,4-TETRAHYDROXYBUTYL)-1H-IMIDAZOL-2-YL]ETHANONE
2-acetyl-4(5)-tetrahydroxybutylimidazole
2-ACETYL-4(5)-(1,2,3,4-TETRAHYDROXYBUTYL)-IMIDAZOLE (THI)
2-Athbi
Ethanone, 1-(4-(1,2,3,4-tetrahydroxybutyl)-1H-imidazol-2-yl)-, (1R-(1R*,2S*,3R*))-
2-Acetyl-5-tetrahydroxybutyl Imidazole
Ethanone, 1-[5-[(1R,2S,3R)-1,2,3,4-tetrahydroxybutyl]-1H-iMidazol-2-yl]-
Ethanone, 1-[4-(1,2,3,4-tetrahydroxybutyl)-1H-iMidazol-2-yl]-, [1R-(1R*,2S*,3R*)]- (9CI)
2-Acetyl-4-(1,2,3,4-tetrahydroxybutyl)iMidazole, 97%
2-Acetyl-5-tetrahydroxybutyl iMidazole (THI)
1-[5-[(1R,2S,3R)-1,2,3,4-Tetrahydroxybutyl]-1H-imidazol-2-yl]ethanone
(R,S,R)-2-Acetyl-4-(1,2,3,4-tetrahydroxybutyl)-imidazole
(1'R,2'S,3'R)-2-acetyl-4(5)-(1',2',3',4'-tetrahydroxy-1'-butyl)imidazole
2-Acetyl-4-tetrahydroxybutylimidazole Standard
1-(5-(1,1,2,2-Tetrahydroxybutyl)-1H-imidazol-2-yl)ethanone
2-Acetyl-4-(1,2,3,4-tetrahydroxybutyl)imidazole, 97%,
Inhibitor,inhibit,2 ATHBI,2ATHBI
94944-70-4