PF-06761281

PF-06761281 Struktur
1854061-19-0
CAS-Nr.
1854061-19-0
Englisch Name:
PF-06761281
Synonyma:
PF-06761281;PF-06761281 >=97% (HPLC);Butanedioic acid, 2-hydroxy-2-[2-(2-methoxy-5-methyl-3-pyridinyl)ethyl]-, (2R)-
CBNumber:
CB04670535
Summenformel:
C13H17NO6
Molgewicht:
283.28
MOL-Datei:
1854061-19-0.mol

PF-06761281 Eigenschaften

Siedepunkt:
469.7±45.0 °C(Predicted)
Dichte
1.358±0.06 g/cm3(Predicted)
storage temp. 
-20°C
pka
3.37±0.28(Predicted)
Aggregatzustand
powder
Farbe
white to beige
Sicherheit
  • Risiko- und Sicherheitserklärung
  • Gefahreninformationscode (GHS)
RIDADR  UN 2811 6.1 / PGIII
Bildanzeige (GHS) GHS hazard pictograms
Alarmwort Achtung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H301 Giftig bei Verschlucken. Akute Toxizität oral Kategorie 3 Achtung GHS hazard pictogramssrc="/GHS06.jpg" width="20" height="20" /> P264, P270, P301+P310, P321, P330,P405, P501
Sicherheit

PF-06761281 Chemische Eigenschaften,Einsatz,Produktion Methoden

Verwenden

PF-06761281 has been used as a SLC13A family inhibitor, in rats to determine its unbound partition coefficient (Kpuu), to estimate its potency as a drug.

Allgemeine Beschreibung

PF-06761281 is a small, polar dicarboxylate compound. Its structure is similar to citrate, which is the endogenous substrate of Na+-citrate cotransporter (NaCT). It is a novel, potent inhibitor of SLC13a2/3/5 (solute channel) family, along with selectivity for NaCT.

Biochem/physiol Actions

PF-06761281 is an inhibitor of the sodium-coupled citrate transporter (NaCT or SLC13A5), which may be a target for tretment and prevention of metabolic disorders. The SLC13 transporters SLC13A2 (NaDC1), SLC13A3 (NaDC3), and SLC13A5 (NaCT) co-transport di- and tricarboxylates with multiple sodium ions into cells. PF-06761281 inhibits citrate uptake with an IC50 of 740 nM for NaCT in human hepatocytes. PF-06761281 has >25-fold in vitro selectivity for NaCT over NaDC1 and NaDC3 and was inactive in a selectivity panel of 65 targets.

PF-06761281 Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


PF-06761281 Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 4)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Sigma-Aldrich 021-61415566 800-8193336
orderCN@merckgroup.com China 51471 80
DC Chemicals 021-58447131 13564518121
sales@dcchemicals.com China 9412 58
Energy Chemical 021-58432009 400-005-6266
marketing1@energy-chemical.com China 44843 58
Beijing Biocreative Technology Co., Ltd. 15522676233
3007606172@qq.com China 1249 58

  • PF-06761281
  • PF-06761281 >=97% (HPLC)
  • Butanedioic acid, 2-hydroxy-2-[2-(2-methoxy-5-methyl-3-pyridinyl)ethyl]-, (2R)-
  • 1854061-19-0
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