PF-06761281

1854061-19-0

CAS-Nr.: 1854061-19-0

Englisch Name:: PF-06761281

Synonyma:: PF-06761281;PF-06761281 >=97% (HPLC);Butanedioic acid, 2-hydroxy-2-[2-(2-methoxy-5-methyl-3-pyridinyl)ethyl]-, (2R)-

CBNumber:: CB04670535

Summenformel:: C13H17NO6

Molgewicht:: 283.28

MOL-Datei:: 1854061-19-0.mol

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Eigenschaften Sicherheit Verwendungswort Produktionsfirma 4

PF-06761281 Eigenschaften

Siedepunkt:: 469.7±45.0 °C(Predicted)

Dichte: 1.358±0.06 g/cm3(Predicted)

storage temp.: -20°C

pka: 3.37±0.28(Predicted)

Aggregatzustand: powder

Farbe: white to beige

Sicherheit

Risiko- und Sicherheitserklärung
Gefahreninformationscode (GHS)

RIDADR	UN 2811 6.1 / PGIII

Bildanzeige (GHS)

Alarmwort

Achtung

Gefahrenhinweise

Code	Gefahrenhinweise	Gefahrenklasse	Abteilung	Alarmwort	Symbol	P-Code
H301	Giftig bei Verschlucken.	Akute Toxizität oral	Kategorie 3	Achtung	src="/GHS06.jpg" width="20" height="20" />	P264, P270, P301+P310, P321, P330,P405, P501

Sicherheit

PF-06761281 Chemische Eigenschaften,Einsatz,Produktion Methoden

Verwenden

PF-06761281 has been used as a SLC13A family inhibitor, in rats to determine its unbound partition coefficient (Kpuu), to estimate its potency as a drug.

Allgemeine Beschreibung

PF-06761281 is a small, polar dicarboxylate compound. Its structure is similar to citrate, which is the endogenous substrate of Na⁺-citrate cotransporter (NaCT). It is a novel, potent inhibitor of SLC13a2/3/5 (solute channel) family, along with selectivity for NaCT.

Biochem/physiol Actions

PF-06761281 is an inhibitor of the sodium-coupled citrate transporter (NaCT or SLC13A5), which may be a target for tretment and prevention of metabolic disorders. The SLC13 transporters SLC13A2 (NaDC1), SLC13A3 (NaDC3), and SLC13A5 (NaCT) co-transport di- and tricarboxylates with multiple sodium ions into cells. PF-06761281 inhibits citrate uptake with an IC50 of 740 nM for NaCT in human hepatocytes. PF-06761281 has >25-fold in vitro selectivity for NaCT over NaDC1 and NaDC3 and was inactive in a selectivity panel of 65 targets.

PF-06761281 Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

PF-06761281 Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 4)Lieferanten

Firmenname	Telefon	E-Mail	Land	Produktkatalog	Edge Rate
Sigma-Aldrich	021-61415566 800-8193336	orderCN@merckgroup.com	China	51471	80
DC Chemicals	021-58447131 13564518121	sales@dcchemicals.com	China	9412	58
Energy Chemical	021-58432009 400-005-6266	marketing1@energy-chemical.com	China	44843	58
Beijing Biocreative Technology Co., Ltd.	15522676233	3007606172@qq.com	China	1249	58

PF-06761281
PF-06761281 >=97% (HPLC)
Butanedioic acid, 2-hydroxy-2-[2-(2-methoxy-5-methyl-3-pyridinyl)ethyl]-, (2R)-
1854061-19-0