Clofibrid

clofibride Struktur
26717-47-5
CAS-Nr.
26717-47-5
Bezeichnung:
Clofibrid
Englisch Name:
clofibride
Synonyma:
MG-46;Lipenan;clofibride;[4-(dimethylamino)-4-oxobutyl] 2-(4-chlorophenoxy)-2-methylpropanoate;2-(p-Chlorophenoxy)-2-methylpropionic acid 4-(dimethylamino)-4-oxobutyl ester;2-(4-Chlorophenoxy)-2-methylpropionic acid 4-(dimethylamino)-4-oxobutyl ester;2-(4-Chlorophenoxy)-2-methylpropanoic acid 4-(dimethylamino)-4-oxobutyl ester;Propanoic acid, 2-(4-chlorophenoxy)-2-methyl-, 4-(dimethylamino)-4-oxobutyl ester
CBNumber:
CB0941813
Summenformel:
C10H13ClO-
Molgewicht:
184.66262
MOL-Datei:
26717-47-5.mol

Clofibrid Eigenschaften

Schmelzpunkt:
34°C
Siedepunkt:
195°C (rough estimate)
Dichte
1.1635 (rough estimate)
Brechungsindex
1.6800 (estimate)

Sicherheit

Clofibrid Chemische Eigenschaften,Einsatz,Produktion Methoden

Originator

Lipenan,Charpentier,France,1974

Manufacturing Process

48.5 parts of ethyl 4'-chlorophenoxyisobutyrate are dissolved in 200 parts by volume of dry toluene in the presence of 262 parts of 4-hydroxy-N,Ndimethylbutyramide and 2 parts of aluminum isopropylate. The solution is heated for 8 hours, while collecting the toluene-ethanol azeotrope, in an apparatus provided with a distillation column at a controllable rate of reflux. After this it is filtered ,the solvent is evaporated in vacuo and the residue is distilled. An almost colorless, slightly yellow oil is obtained, the purity of which by chromatographic examination in the gaseous phase is of the order of 99.5%. Its boiling point is 175°C under 0.1 torr.
48.5 parts of ethyl 4'-chlorophenoxyisobutyrate are dissolved in 200 parts by volume of dry toluene in the presence of 262 parts of 4-hydroxy-N,Ndimethylbutyramide and 2 parts of aluminum isopropylate. The solution is heated for 8 hours, while collecting the toluene-ethanol azeotrope, in an apparatus provided with a distillation column at a controllable rate of reflux. After this it is filtered ,the solvent is evaporated in vacuo and the residue is distilled. An almost colorless, slightly yellow oil is obtained, the purity of which by chromatographic examination in the gaseous phase is of the order of 99.5%. Its boiling point is 175°C under 0.1 torr.
The product can be recrystallized. For this, it is dissolved, for example, at the ambient temperature in petrol ether, ethyl ether or isopropyl ether, and this solution is cooled at about -50°C while stirring. After drying over sulfuric acid under vacuum, white needles of very great purity are thus obtained.

Therapeutic Function

Antihyperlipidemic

Clofibrid Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Clofibrid Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 9)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Hubei Jusheng Technology Co.,Ltd.
18871490254
linda@hubeijusheng.com CHINA 28180 58
TargetMol Chemicals Inc.
+1-781-999-5354
support@targetmol.com United States 19973 58
TargetMol Chemicals Inc. 4008200310
marketing@tsbiochem.com China 24131 58

26717-47-5(Clofibrid)Verwandte Suche:


  • 2-(4-Chlorophenoxy)-2-methylpropanoic acid 4-(dimethylamino)-4-oxobutyl ester
  • 2-(4-Chlorophenoxy)-2-methylpropionic acid 4-(dimethylamino)-4-oxobutyl ester
  • 2-(p-Chlorophenoxy)-2-methylpropionic acid 4-(dimethylamino)-4-oxobutyl ester
  • Lipenan
  • MG-46
  • clofibride
  • [4-(dimethylamino)-4-oxobutyl] 2-(4-chlorophenoxy)-2-methylpropanoate
  • Propanoic acid, 2-(4-chlorophenoxy)-2-methyl-, 4-(dimethylamino)-4-oxobutyl ester
  • 26717-47-5
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