Calciumdobesilat

Calcium dobesilate Struktur
20123-80-2
CAS-Nr.
20123-80-2
Bezeichnung:
Calciumdobesilat
Englisch Name:
Calcium dobesilate
Synonyma:
205-E;doxium;dexium;Calciumdobesilat;CALCIUM DOBESILATE;5-benzenesulfonate;calcium dihydroxy-2;Qiangbenhuangsuangai;Dobesilate calcium salt;CALCIUMDOBESILATECAPSULE
CBNumber:
CB5713183
Summenformel:
2C6H5O5S.Ca
Molgewicht:
418.41
MOL-Datei:
20123-80-2.mol

Calciumdobesilat Eigenschaften

Schmelzpunkt:
>300° (dec)
storage temp. 
Inert atmosphere,Room Temperature
Löslichkeit
H2O: soluble15mg/mL, clear
Aggregatzustand
powder
Farbe
white to beige
Stabilität:
Hygroscopic
InChIKey
QGNBTYAQAPLTMX-UHFFFAOYSA-L
CAS Datenbank
20123-80-2(CAS DataBase Reference)
Sicherheit
  • Risiko- und Sicherheitserklärung
  • Gefahreninformationscode (GHS)
Kennzeichnung gefährlicher Xi
R-Sätze: 36/37/38
S-Sätze: 26
WGK Germany  3
HazardClass  IRRITANT
Toxizität LD50 in mice: 700 mg/kg (Esteve-Subirana)
Bildanzeige (GHS) GHS hazard pictograms
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H315 Verursacht Hautreizungen. Hautreizung Kategorie 2 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P280, P302+P352, P321,P332+P313, P362
H319 Verursacht schwere Augenreizung. Schwere Augenreizung Kategorie 2 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P280, P305+P351+P338,P337+P313P
H335 Kann die Atemwege reizen. Spezifische Zielorgan-Toxizität (einmalige Exposition) Kategorie 3 (Atemwegsreizung) Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" />
Sicherheit
P261 Einatmen von Staub vermeiden.
P264 Nach Gebrauch gründlich waschen.
P264 Nach Gebrauch gründlich waschen.
P271 Nur im Freien oder in gut belüfteten Räumen verwenden.
P280 Schutzhandschuhe/Schutzkleidung/Augenschutz tragen.
P302+P352 BEI BERÜHRUNG MIT DER HAUT: Mit viel Wasser/... (Hersteller kann, falls zweckmäßig, ein Reinigungsmittel angeben oder, wenn Wasser eindeutig ungeeignet ist, ein alternatives Mittel empfehlen) waschen.
P305+P351+P338 BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach Möglichkeit entfernen. Weiter spülen.

Calciumdobesilat Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

Calcium dobesilate is a vasoprotective. It is the calcium salt of dobesilic acid. It is a synthetic molecule with the ability to reduce capillary permeability in the body. In Switzerland the drug is sold by the pharmaceutical company OM Pharma under the trade name of Doxium in capsules containing 500 mg of active ingredient.
Calcium dobesilate is indicated in states of fragility and altered capillary permeability, e.g. diabetic retinopathy, chronic venous disease and hemorrhoidal disease. In combination with lidocaine or with lidocaine and dexamethasone, the drug enters the composition of preparations for the therapy of hemorrhoidal disease. In association with potassium hydrodex-sulfate[citation needed] enters the composition of adjuvant gels in the treatment of varicose veins. The efficacy of calcium dobesilate has been described in patients with microangiopathies such as diabetic retinopathy and diabetic nephropathy.

Chemische Eigenschaften

White or almost white, hygroscopic powder.

Verwenden

Calcium dobesilate is an antioxidant that has been used to treat diabetic retinopathy, in which it slows progression of the disease during long-term oral treatment by reducing microvascular permeability, leading to improved visual acuity. It not only acts as an antioxidant but also stimulates endothelial production of nitric oxide.

Indications

Calcium dobesilate (CaD) is a widely prescribed veno-tonic drug for CVI, diabetic retinopathy, and the symptoms of hemorrhoid attacks.
Calcium dobesilate is also almost the only one angioprotective drug that recently remains the object of interest in treatment of diabetic retinopathy including clinical studies (Leal et al. 2010, Einarsdottir & Stefansson, 2009, Ribeiro et al., 2006), and even it was used as a standard for determination of the particular activity of a traditional Chinese herbal medicine preparation (Luo et al. 2009).

Allgemeine Beschreibung

Dobesilate calcium belongs to the family of fibroblast growth factor (FGF) inhibitors.

Nebenwirkungen

Fever
Skin reactions
Arthralgia(joint pain)
Gastrointestinal disorders
Agranulocytosis (lower white blood cell count)

Calciumdobesilat Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Calciumdobesilat Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 340)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Hebei Yanxi Chemical Co., Ltd.
+8617531190177
peter@yan-xi.com China 5993 58
Hebei Guanlang Biotechnology Co,.LTD
+8619930503252
daisy@crovellbio.com China 5964 58
XuZhou Magic Biotechnology Co., Ltd.
+undefined13921770081
SVP01@magicbiotech.cn China 92 58
airuikechemical co., ltd.
+undefined86-15315557071
sales02@airuikechemical.com China 994 58
Hebei Zhuanglai Chemical Trading Co.,Ltd
+8613343047651
admin@zlchemi.com China 476 58
Henan Tianfu Chemical Co.,Ltd.
+86-0371-55170693 +86-19937530512
info@tianfuchem.com China 21691 55
Zjartschem
+86-571-8723 8903 jocelynpan@zjarts.com
jocelynpan@zjarts.com CHINA 993 58
career henan chemical co
+86-0371-86658258
sales@coreychem.com China 29914 58
SHANDONG ZHI SHANG CHEMICAL CO.LTD
+86 18953170293
sales@sdzschem.com China 2931 58
Hubei Jusheng Technology Co.,Ltd.
18871490254
linda@hubeijusheng.com CHINA 28180 58

20123-80-2(Calciumdobesilat)Verwandte Suche:


  • CALCIUM DOBESILATE
  • Calcium Dobesilate Mnohydrate
  • CALIUM DOBESILATE MONOHYDRATE
  • CALCIUM DOBESILATE 1-HYDRATE
  • 2,5-Dihydroxybenzenesulfonic acid, calcium salt
  • 2,5-dihydroxy-benzenesulfonic aci calcium salt
  • dexium
  • doxium
  • hydroquinone calcium sulfonate
  • CALCIUMDOBESILATECAPSULE
  • 1,2-dihydroxybenzolsulfonic acid calcium salt (2:1)
  • Benzenesulfonic acid, 2,5-dihydroxy-, calcium salt (2:1)
  • 205-E
  • Bis(2,5-dihydroxybenzenesulfonic acid)calcium salt
  • Bis[2,5-dihydroxybenzenesulfonic acid]calcium salt
  • CalciuM Dobesilat Monohydrate
  • Calcium bis(2,5-dihydroxybenzenesulfonate)
  • 2,5-dihydroxybenzoic acid calciuM
  • Qiangbenhuangsuangai
  • Calcium 2,5-dihydroxybenzenesulfonate
  • Calciumdobesilat
  • 5-benzenesulfonate
  • calcium dihydroxy-2
  • Caium Dobesilate Mnohydrate
  • Calcium dobesilate USP/EP/BP
  • CAS 20123-80-2 Calcium dobesilate
  • 13C6]-Dobesilate calcium salt
  • Dobesilate calcium salt
  • 20123-80-2
  • 20123-20-8
  • 2C6H5O5SCa
  • C6H5O5S2CaC12H10Ca2
  • C12H10CaO10S2
  • C6H5O5S2CaC12H10Ca2O10S2
  • 2C6H5O5SCaH2O
  • C12H10CaO10S2H2O
  • C6H5O5S2Ca
  • C12H12CaO11S2
  • C12H10CaO10S2xH2Oanhydrous
  • API
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