clofibride
- CAS No.
- 26717-47-5
- Chemical Name:
- clofibride
- Synonyms
- MG-46;Lipenan;clofibride;[4-(dimethylamino)-4-oxobutyl] 2-(4-chlorophenoxy)-2-methylpropanoate;2-(p-Chlorophenoxy)-2-methylpropionic acid 4-(dimethylamino)-4-oxobutyl ester;2-(4-Chlorophenoxy)-2-methylpropionic acid 4-(dimethylamino)-4-oxobutyl ester;2-(4-Chlorophenoxy)-2-methylpropanoic acid 4-(dimethylamino)-4-oxobutyl ester;Propanoic acid, 2-(4-chlorophenoxy)-2-methyl-, 4-(dimethylamino)-4-oxobutyl ester
- CBNumber:
- CB0941813
- Molecular Formula:
- C10H13ClO-
- Molecular Weight:
- 184.66262
- MDL Number:
- MFCD00865712
- MOL File:
- 26717-47-5.mol
| Melting point | 34°C |
|---|---|
| Boiling point | 195°C (rough estimate) |
| Density | 1.1635 (rough estimate) |
| refractive index | 1.6800 (estimate) |
| FDA UNII | 0S9SLS3L93 |
| ATC code | C10AB10 |
clofibride Chemical Properties,Uses,Production
Originator
Lipenan,Charpentier,France,1974
Definition
ChEBI: Clofibride is a monocarboxylic acid.
Manufacturing Process
48.5 parts of ethyl 4'-chlorophenoxyisobutyrate are dissolved in 200 parts by
volume of dry toluene in the presence of 262 parts of 4-hydroxy-N,Ndimethylbutyramide and 2 parts of aluminum isopropylate. The solution is
heated for 8 hours, while collecting the toluene-ethanol azeotrope, in an
apparatus provided with a distillation column at a controllable rate of reflux.
After this it is filtered ,the solvent is evaporated in vacuo and the residue is
distilled. An almost colorless, slightly yellow oil is obtained, the purity of which
by chromatographic examination in the gaseous phase is of the order of
99.5%. Its boiling point is 175°C under 0.1 torr.
48.5 parts of ethyl 4'-chlorophenoxyisobutyrate are dissolved in 200 parts by
volume of dry toluene in the presence of 262 parts of 4-hydroxy-N,Ndimethylbutyramide and 2 parts of aluminum isopropylate. The solution is
heated for 8 hours, while collecting the toluene-ethanol azeotrope, in an
apparatus provided with a distillation column at a controllable rate of reflux.
After this it is filtered ,the solvent is evaporated in vacuo and the residue is
distilled. An almost colorless, slightly yellow oil is obtained, the purity of which
by chromatographic examination in the gaseous phase is of the order of
99.5%. Its boiling point is 175°C under 0.1 torr.
The product can be recrystallized. For this, it is dissolved, for example, at the
ambient temperature in petrol ether, ethyl ether or isopropyl ether, and this
solution is cooled at about -50°C while stirring. After drying over sulfuric acid
under vacuum, white needles of very great purity are thus obtained.
Therapeutic Function
Antihyperlipidemic
clofibride Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28180 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
| TargetMol Chemicals Inc. | 4008200310 | marketing@tsbiochem.com | China | 24131 | 58 |
| Supplier | Advantage |
|---|---|
| Hubei Jusheng Technology Co.,Ltd. | 58 |
| TargetMol Chemicals Inc. | 58 |
| TargetMol Chemicals Inc. | 58 |