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5,11-Dihydro-11-[(4-methylpiperazin-1-yl)acetyl]-6H-pyrido[2,3-b][1,4]benzodiazepin-6-ondihydrochlorid

Pirenzepine hydrochloride Struktur
29868-97-1
CAS-Nr.
29868-97-1
Bezeichnung:
5,11-Dihydro-11-[(4-methylpiperazin-1-yl)acetyl]-6H-pyrido[2,3-b][1,4]benzodiazepin-6-ondihydrochlorid
Englisch Name:
Pirenzepine hydrochloride
Synonyma:
Tabe;Maghen;Leblon;l-s519;Ulcosan;Renzepin;Gasteril;ls519cl2;Bisvanil;Gastricur
CBNumber:
CB1245572
Summenformel:
C19H22ClN5O2
Molgewicht:
387.87
MOL-Datei:
29868-97-1.mol
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5,11-Dihydro-11-[(4-methylpiperazin-1-yl)acetyl]-6H-pyrido[2,3-b][1,4]benzodiazepin-6-ondihydrochlorid Eigenschaften

Schmelzpunkt:
248-250°C
storage temp. 
Inert atmosphere,2-8°C
Löslichkeit
H2O: 50 mg/mL
Aggregatzustand
powder
Farbe
white
Wasserlöslichkeit
Soluble to 100 mM in water
Sensitive 
Hygroscopic
CAS Datenbank
29868-97-1(CAS DataBase Reference)
Sicherheit
  • Risiko- und Sicherheitserklärung
  • Gefahreninformationscode (GHS)
WGK Germany  2
RTECS-Nr. UU7883000
HS Code  2933.99.7500
Toxizität dog,LD50,intravenous,62500ug/kg (62.5mg/kg),Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 19, Pg. 544, 1988.
Bildanzeige (GHS) GHS hazard pictograms
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H302 Gesundheitsschädlich bei Verschlucken. Akute Toxizität oral Kategorie 4 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P270, P301+P312, P330, P501
H315 Verursacht Hautreizungen. Hautreizung Kategorie 2 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P280, P302+P352, P321,P332+P313, P362
H317 Kann allergische Hautreaktionen verursachen. Sensibilisierung der Haut Kategorie 1A Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P261, P272, P280, P302+P352,P333+P313, P321, P363, P501
H319 Verursacht schwere Augenreizung. Schwere Augenreizung Kategorie 2 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P280, P305+P351+P338,P337+P313P
H402 Harmful to aquatic life Hazardous to the aquatic environment, acute hazard Category 3
Sicherheit
P261 Einatmen von Staub vermeiden.
P264 Nach Gebrauch gründlich waschen.
P264 Nach Gebrauch gründlich waschen.
P270 Bei Gebrauch nicht essen, trinken oder rauchen.
P272 Kontaminierte Arbeitskleidung nicht außerhalb des Arbeitsplatzes tragen.
P273 Freisetzung in die Umwelt vermeiden.
P280 Schutzhandschuhe/Schutzkleidung/Augenschutz tragen.
P302+P352 BEI BERÜHRUNG MIT DER HAUT: Mit viel Wasser/... (Hersteller kann, falls zweckmäßig, ein Reinigungsmittel angeben oder, wenn Wasser eindeutig ungeeignet ist, ein alternatives Mittel empfehlen) waschen.
P337+P313 Bei anhaltender Augenreizung: Ärztlichen Rat einholen/ärztliche Hilfe hinzuziehen.

5,11-Dihydro-11-[(4-methylpiperazin-1-yl)acetyl]-6H-pyrido[2,3-b][1,4]benzodiazepin-6-ondihydrochlorid Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

Pirenzepine is an antagonist of M1 muscarinic acetylcholine receptors (Ki = 11.48 nM). It is selective for M1 over M2, M3, and M4 receptors (Kis = 602.56, 151.36, and 199.53 nM, respectively). Pirenzepine inhibits ascending reflex contraction of the circular smooth muscle in isolated guinea pig ileal segments induced by intraluminal balloon inflation (IC50 = 501.19 nM). It inhibits methacholine-induced increases in ileal pressure in guinea pigs (ID50 = 724.44 nmol/kg). Pirenzepine inhibits oxotremorine-induced gastric ulcer, gastric acid secretion, and salivation in rats (ED50s = 13, 37.5, and 620 μg/kg i.v., respectively). It prevents form-deprivation myopia (FDM) in a chick model of experimental myopia.

Chemische Eigenschaften

Solid

Allgemeine Beschreibung

Pirenzepine dihydrochloride is an anticholinergic agent. It is also considered as an antiulcer drug. It is used to treat myopia, gastric and duodenal ulcers. Pirenzepine dihydrochloride induces the dimerization of muscarinic M1 receptors.

5,11-Dihydro-11-[(4-methylpiperazin-1-yl)acetyl]-6H-pyrido[2,3-b][1,4]benzodiazepin-6-ondihydrochlorid Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Chloracetylchlorid N,N-Diethylethanamin 1-Methylpiperazin 4-Amino-2-methyl-10H-thiene[2,3-b][1,5]benzodiazepine hydrochloride

Downstream Produkte

Pirenzepine

5,11-Dihydro-11-[(4-methylpiperazin-1-yl)acetyl]-6H-pyrido[2,3-b][1,4]benzodiazepin-6-ondihydrochlorid Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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29868-97-1(5,11-Dihydro-11-[(4-methylpiperazin-1-yl)acetyl]-6H-pyrido[2,3-b][1,4]benzodiazepin-6-ondihydrochlorid)Verwandte Suche:

2-Piperazin-1-ylethylamin 2,6-Dimethyloct-7-en-2-ol 2,3-Dihydro-5,6-dimethoxy-2-[[1-(phenylmethyl)-4-piperidinyl]methyl]-1H-inden-1-one hydrochloride Pirenzepine 2-Piperidinessigsäure-alpha-phenyl-methylester-hydrochlorid Acetylchlorid [2S-[2α,5α,6β(S*)]]-6-[[[[(4-Ethyl-2,3-dioxopiperazin-1-yl)carbonyl]amino]phenylacetyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptan-2-carbonsure 2,4-Pentandion 4-(4-Chlorphenyl)-4-hydroxy-N,N-dimethyl-α,α-diphenylpiperidin-1-butyramidmonohydrochlorid N-Methyl-N-(1-methylethyl)-N-(2-((9H-xanthen-9-yl-carbonyl)oxy)ethyl)-2-propanaminium-bromid Piperazine ferulate 2,4'-Dimethyl-3-piperidinopropiophenonhydrochlorid Topotecan hydrochloride Tetryzolinhydrochlorid Robenidinhydrochlorid 1-β-D-Arabinofuranosylcytosinhydrochlorid 2-Chlor-α-[(isopropylamino)methyl]benzylalkoholhydrochlorid Moroxydinhydrochlorid
  • Gasteril
  • Leblon
  • Maghen
  • Renzepin
  • Tabe
  • Ulcosan
  • Ulcuforton
  • 5,11-dihydro-11-[2-(4-methyl-1-piperazinyl)acetyl]-6H-pyrido[2,3-β][1,4]benzo- diazepin-6-one Dihydrochloride
  • Gastricur
  • 11-[2-(4-methylpiperazin-1-yl)acetyl]-5H-pyrido[2,3-b][1,4]benzodiazepin-6-one dihydrochloride
  • 11-[2-(4-methylpiperazin-1-yl)ethanoyl]-5H-pyrido[2,3-b][1,4]benzodiazepin-6-one dihydrochloride
  • Pirenzepine dihydrochloride,5,11-Dihydro-11-[(4-methyl-1-piperazinyl)acetyl]-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one dihydrochloride
  • Duogastral,Durapirenz,Gasteril,Gastrozepin,Leblon,Maghen,Renzepin,Tabe,Ulcuforton,Ulcosan,2HCl
  • 5,11-Dihydro-11-((4-methylpiperazin-1-yl)acetyl)-6H-pyrido(2,3-b)-(1,4)benzodiazepin-6-onedihydrochloride
  • Pirenzepin2HCl
  • 5,11-dihydro-11-[2-(4-methyl-1-piperazinyl)acetyl]-6H-pyrido[2,3-b][1,4]benzo- diazepin-6-one Dihydrochloride
  • Duogastral
  • Durapirenz
  • Pirenzepine hydrochl
  • HCl pirenzepine
  • 5,11-DIHYDRO-11-[(4-METHYL-1-PIPERAZINYL)ACETYL]-6H-PYRIDO-[2,3-B][1,4] BENZODIAZEPIN-6-ONE DIHYDROBROMIDE
  • 5,11-DIHYDRO-11-[(4-METHYL-1-PIPERAZINYL)ACETYL]-6H-PYRIDO-[2,3-B] [1,4]BENZODIAZEPIN-6-ONE DIHYDROCHLORIDE
  • 5,11-dihydro-11-[(4-methylpiperazin-1-yl)acetyl]-6h-pyrido[2,3-b][1,4]benzodiazepin-6-one dihydrochloride
  • Pirenzepine Hydrochloride Hydrate
  • 5,11-Dihydro-11-((4-methylpiperazin-1-yl)acetyl)-6H-pyrido(2,3-b)-(1,4)benzodiazepin-6-one dihydrochloride
  • Pirenzepine HCL
  • pirenzeping hydrochloride
  • PIRENZEPINE 2HCL
  • PIRENZEPINE DIHYDROCHLORIDE
  • PIRENZEPINE HCL HYDRATE
  • PIRENZEPINE HYDROCHLORIDE
  • l-s519
  • ls519cl2
  • ls519dihydrochloride
  • 6H-Pyrido[2,3-b][1,4]benzodiazepin-6-one,5,11-dihydro-11-[2-(4-methyl-1-piperazinyl)acetyl]-, hydrochloride (1:2)
  • 11-[2-(4-methyl-1-piperazinyl)-1-oxoethyl]-5H-pyrido[2,3-b][1,4]benzodiazepin-6-one hydrate hydrochloride
  • Pirenzepine Dihydrochloride Monohyd
  • Pirenzepine dihydrochloride monohydrate CRS
  • Bisvanil
  • Pirenzepine hydrochloride USP/EP/BP
  • 11-(2-(4-Methylpiperazin-1-yl)acetyl)-5,11-dihydro-6H-benzo[e]pyrido[3,2-b][1,4]diazepin-6-one dihydrochloride
  • TIANFU-CHEM - Pirenzepine hydrochloride
  • 29868-97-1
  • 29368-97-1
  • 29808-97-1
  • C19H23Cl2N5O2
  • C19H21N5O22HCl
  • Inhibitor
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
  • Acetylcholine receptor
  • All Inhibitors
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