ChemicalBook > Produktkatalog >Bio- und Chemieingenieurwesen >Inhibitoren >Mitogen-aktivierte Proteinkinase (MAPK) >Raf-Inhibitoren >CEP-32496 (free base)

CEP-32496 (free base)

1188910-76-0

CAS-Nr.: 1188910-76-0

Englisch Name:: CEP-32496 (free base)

Synonyma:: CS-1683;AC013773;RXDX-105;AC 013773;Agerafenib;RXDX-105 (CEP-32496);CEP-32496 (free base);AC-013773. Agerafenib;Agerafenib (RXDX-105);Agerafenib (CEP-32496)

CBNumber:: CB12627682

Summenformel:: C24H22F3N5O5

Molgewicht:: 517.46

MOL-Datei:: 1188910-76-0.mol

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Eigenschaften Sicherheit Verwendungswort Produktionsfirma 96

CEP-32496 (free base) Eigenschaften

storage temp.: Store at -20°C

Löslichkeit: ≥25.85 mg/mL in DMSO; insoluble in H2O; insoluble in EtOH

Aggregatzustand: A crystalline solid

CAS Datenbank: 1188910-76-0

Sicherheit

CEP-32496 (free base) Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

B-Raf is a MAP kinase kinase kinase, which functions downstream of Ras family GTPases to activate MEK1/2 and ERK1/2 signaling. Mutations of B-Raf, particularly at Val⁶⁰⁰, are common in melanomas and melanocytic nevi. CEP-32496 is a potent inhibitor of B-Raf^V600E (K_d = 14 nM in an in vitro binding assay). It blocks B-Raf^V600E-dependent phosphorylation of MEK in human melanoma A375 and colorectal cancer COLO 205 cells (IC₅₀s = 78 and 60 nM, respectively). CEP-32496 binds kinases other than B-Raf but displays selective cytotoxicity for cells expressing B-Raf^V600E. It displays good oral bioavailability in rats, dogs, and monkeys and has single oral dose pharmacodynamics inhibition of both pMEK and pERK in B-Raf^V600E colon carcinoma xenografts in nude mice.

Verwenden

CEP 32496 is an orally active BRAFV600E inhibitor with selective cellular and in vivo antitumor activity.

CEP-32496 (free base) Upstream-Materialien And Downstream Produkte

Upstream-Materialien

[5-(2,2,2-TRIFLUORO-1,1-DIMETHYL-ETHYL)-ISOXAZOL-3-YL]-CARBAMIC ACID PHENYL ESTER 5-(1,1,1-Trifluoro-2-methylpropan-2-yl)isoxazol-3-amine methyl 3,3,3-trifluoro-2,2-dimethylpropanoate 1188911-73-0 3,3,3-Trifluoro-2,2-dimethylpropionic acid 3-[(6,7-dimethoxy-4-quinazolinyl)oxy]aniline 4-Chloro-6,7-dimethoxyquinazoline 3-Aminophenol

Downstream Produkte

CEP-32496 (free base) Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 96)Lieferanten

Firmenname	Telefon	E-Mail	Land	Produktkatalog	Edge Rate
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32686	60
Hubei Jusheng Technology Co.,Ltd.	18871490254	linda@hubeijusheng.com	CHINA	28180	58
Chongqing Chemdad Co., Ltd	+86-023-61398051 +8613650506873	sales@chemdad.com	China	39916	58
career henan chemical co	+86-0371-86658258 15093356674;	factory@coreychem.com	China	29826	58
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	19892	58
HANGZHOU CLAP TECHNOLOGY CO.,LTD	86-571-88216897,88216896 13588875226	sales@hzclap.com	CHINA	6313	58
Shenzhen Shengda Pharma Limited	755-85269922 +8613424394241	sales@shengdapharm.com	CHINA	310	58
Hefei Hirisun Pharmatech Co., Ltd	+8615056975894	shawn@hirisunpharm.com	CHINA	9923	58
Zhejiang J&C Biological Technology Co.,Limited	+1-2135480471 +1-2135480471	sales@sarms4muscle.com	China	10523	58
InvivoChem	+1-708-310-1919 +1-13798911105	sales@invivochem.cn	United States	6393	58

CEP-32496 (free base)
1-[3-[(6,7-Dimethoxyquinazolin-4-yl)oxy]phenyl]-3-[5-(1,1,1-trifluoro-2-methylpropan-2-yl)isoxazol-3-yl]urea
Urea, N-[3-[(6,7-dimethoxy-4-quinazolinyl)oxy]phenyl]-N-[5-(2,2,2-trifluoro-1,1-dimethylethyl)-3-isoxazolyl]-
AC 013773
AC013773
AC-013773. Agerafenib
CEP-32496 FREE BASE;AC013773; AC 013773; AC-013773. AGERAFENIB
1-[3-(6,7-dimethoxyquinazolin-4-yl)oxyphenyl]-3-[5-(1,1,1-trifluoro-2-methylpropan-2-yl)-1,2-oxazol-3-yl]urea
Agerafenib (CEP-32496)
CEP-32496;CEP 32496;CEP32496
CS-1683
Agerafenib
RXDX-105
RXDX-105 (CEP-32496)
CEP-32496 CEP32496 Agerafenib RXDX-105 RXDX105
Agerafenib (RXDX-105)
1188910-76-0
188910-76-0
Inhibitors
MAPK