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Acetohexamid Produkt Beschreibung

ACETOHEXAMIDE Struktur
968-81-0
CAS-Nr.
968-81-0
Bezeichnung:
Acetohexamid
Englisch Name:
ACETOHEXAMIDE
Synonyma:
u14812;u-14812;dimelin;dimelor;dymelor;minoral;ordimel;Cyclamide;tsiklamid;DiMelor-d6
CBNumber:
CB1316029
Summenformel:
C15H20N2O4S
Molgewicht:
324.4
MOL-Datei:
968-81-0.mol

Acetohexamid Eigenschaften

Schmelzpunkt:
188-190° (GB 912789); mp 175-177° (Marshall)
Dichte
1.2528 (rough estimate)
Brechungsindex
1.6930 (estimate)
Löslichkeit
DMSO: ~45 mg/mL
Aggregatzustand
solid
Farbe
white
CAS Datenbank
968-81-0

Sicherheit

S-Sätze: 36
WGK Germany  2
RTECS-Nr. YR7350000

Acetohexamid Chemische Eigenschaften,Einsatz,Produktion Methoden

S-Sätze Betriebsanweisung:

S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.

Verwenden

Acetohexamide is a sulfonylurea derivative. Acetohexamide is a hyopglycemic agent with moderate uricosuric activity. Acetohexamide is a first generation medication used in the treatment of diabetes metilus type 2.

Verwenden

antifungal

Verwenden

Labelled Acetohexamide, a sulfonylurea derivative. Acetohexamide is a hyopglycemic agent with moderate uricosuric activity. Acetohexamide is a first generation medication used in the treatment of diab etes metilus type 2.

Definition

ChEBI: An N-sulfonylurea that is urea in which a hydrogen attached to one of the nitrogens is replaced by a p-acetylphenylsulfonyl group, while a hydrogen attached to the other nitrogen is replaced by a cyclohexyl group.

Trademarks

Dymelor (Lilly).

Allgemeine Beschreibung

White fluffy crystalline powder with almost no odor.

Allgemeine Beschreibung

Acetohexamide is 4-acetyl-N-[(cyclohexylamino)carbonyl]benzenesulfonamide; or 1-[(p-acetylphenyl)sulfonyl]-3-cyclohexylurea; or 1-(p-acetylbenzenesulfonyl)-3-cyclohexylurea(generic). Acetohexamide incorporates the nearly optimal(for potency) cyclohexyl moiety in the “right-hand” sideof its molecular structure, but a p-acetyl substituent on the“left-side” benzene ring that decreases lipophilicity and israpidly biotransformed by reduction to an active metabolitethat is cleared relatively rapidly (see preceding discussion) independentlyof any P450s.

Allgemeine Beschreibung

Acetohexamide, 1-[(p-acetylphenyl)sulfonyl]-3-cyclohexylurea (Dymelor), is relatedchemically and pharmacologically to tolbutamide and chlorpropamide.Like the other sulfonylureas, acetohexamidelowers the blood sugar level, primarily by stimulating the releaseof endogenous insulin.

Air & Water Reaktionen

Water insoluble.

Reaktivität anzeigen

An amide. Organic amides/imides react with azo and diazo compounds to generate toxic gases. Flammable gases are formed by the reaction of organic amides/imides with strong reducing agents. Amides are very weak bases (weaker than water). Imides are less basic yet and in fact react with strong bases to form salts. That is, they can react as acids. Mixing amides with dehydrating agents such as P2O5 or SOCl2 generates the corresponding nitrile. The combustion of these compounds generates mixed oxides of nitrogen (NOx).

Brandgefahr

Flash point data for ACETOHEXAMIDE are not available; however, ACETOHEXAMIDE is probably combustible.

Clinical Use

Acetohexamide is metabolized in the liver to a reducedform, the α -hydroxyethyl derivative. This metabolite, themain one in humans, possesses hypoglycemic activity.Acetohexamide is intermediate between tolbutamide andchlorpropamide in potency and duration of effect on bloodsugar levels.

Sicherheitsprofil

Human reproductive effects by an unspecified route: stillbirth. Mildly toxic by ingestion. When heated to decomposition it emits very toxic fumes of SO, and NOx,.

Acetohexamid Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Acetohexamid Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 46)Lieferanten
Firmenname Telefon Fax E-Mail Land Produktkatalog Edge Rate
Hubei xin bonus chemical co. LTD
86-13657291602
027-59338440 sales@guangaobio.com CHINA 23049 58
J & K SCIENTIFIC LTD. 400-666-7788 +86-10-82848833
86-10-82849933 jkinfo@jkchemical.com;market6@jkchemical.com China 96815 76
3B Pharmachem (Wuhan) International Co.,Ltd. 86-21-50328103 * 801、802、803、804 Mobile:18930552037
86-21-50328109 3bsc@sina.com China 15881 69
LGM Pharma 1-(800)-881-8210
615-250-9817 inquiries@lgmpharma.com United States 1940 70
Chemsky (shanghai) International Co.,Ltd 021-50135380
shchemsky@sina.com China 15426 60
Sinopharm Chemical Reagent Co,Ltd. 86-21-63210123
86-21-63290778 86-21-63218885 sj_scrc@sinopharm.com China 9847 79
Shanghai Fuhe Chemistry Technology Co., Ltd. 0086-21-67651709
0086-21-67651705 cfx759@hotmail.com China 410 57
Shanghai LiuShi Pharmaceutical Technology Co., Ltd. 021-60135539
021-38721356 shlschemical@hotmail.com China 9915 55
Haoyuan Chemexpress Co., Ltd. 86-21-58998985
(86) 21-58955996 apisales@chemexpress.com.cn China 7560 61
MedChemexpress LLC 609-228-6898
609-228-5909 sales@medchemexpress.com United States 4609 58

968-81-0(Acetohexamid)Verwandte Suche:


  • 4-ACETYL-N-[(CYCLOHEXYLAMINO)-CARBONYL]BENZENESULFONAMIDE
  • ACETOHEXAMIDE
  • u-14812
  • ACETOHEXAMIDE, USP GRADE ORAL HYPOGLYCEM IC AGE
  • 1-(p-acetylbenzenesulfonyl)-3-cyclohexylure
  • Cyclamide
  • 1-(4-acetylphenyl)sulfonyl-3-cyclohexylurea
  • 1-(4-acetylphenyl)sulfonyl-3-cyclohexyl-urea
  • 1-cyclohexyl-3-(4-ethanoylphenyl)sulfonyl-urea
  • Acetohexamide (250 mg)
  • BenzenesulfonaMide, 4-acetyl-N-[(cyclohexylaMino)carbonyl]-
  • 1-[(p-Acetylphenyl)su
  • 1-(p-Acetylbenzenesulfonyl)
  • 4-Acetyl-N-[(cyclohexyl-d6-aMino)carbonyl]benzenesulfonaMide
  • AcetohexaMide-d6
  • -d6 DiMelin-d6
  • DiMelor-d6
  • DyMelor-d6
  • GaMadiabet-d6
  • Hypoglicil-d6
  • Metaglucina-d6
  • Minoral-d6
  • OrdiMel-d6
  • TsiklaMid-d6
  • U 14812-d6
  • 1-((p-acetylphenyl)sulfonyl)-3-cyclohexyl-ure
  • 1-((p-acetylphenyl)sulfonyl)-3-cyclohexylurea
  • 1-(p-acetylbenzenesulfonyl)-3-cyclohexylurea
  • 4-acetyl-n-((cyclohexylamino)carbonyl)-benzenesulfonamid
  • 4-acetyl-n-[(cyclohexylamino)carbonyl]-benzenesulfonamid
  • 4-acetyl-n-benzenesulfonamide
  • acetohexamid
  • dimelin
  • dimelor
  • dymelor
  • gamadiaber
  • gamadiabet
  • hypoglicil
  • metaglucina
  • minoral
  • n-(p-acetylphenylsulfonyl)-n’-cyclohexylurea
  • nci-c03247
  • ordimel
  • tsiklamid
  • u14812
  • 968-81-0
  • C15H20N2O4S
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