Arp2/3 Complex Inhibitor II, CK-869 - Calbiochem Chemische Eigenschaften,Einsatz,Produktion Methoden
Allgemeine Beschreibung
A cell-permeable thiazolidinone compound that inhibits actin assembly mediated by actin-related protein Arp2/3 complex of human and bovine, but not yeast, species (IC
50 = 11 μM against bovine Arp2/3). Shown to inhibit the actin filament "comet tails" formation around intracellular
Listeria in infected SKOV3 cells (IC
50 = 7 μM). Structrual studies indicate that CK-869 targets the hydrophobic core in subdomain 1 of Arp3. CK-666 (Cat. No.
182515) and CK-869 exhibit different modes of binding, resulting in their different yeast cross-reactivities. Supplied as a racemic mixture of the active 2S and the inactive 2R enantiomers. CK-312 (Cat. No.
182518) can serve as a negative control.
Arp2/3 Complex Inhibitor II, CK-869 - Calbiochem Upstream-Materialien And Downstream Produkte
Upstream-Materialien
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