Arp2/3 Complex Inhibitor II, CK-869 - Calbiochem

Arp2/3 Complex Inhibitor II, CK-869 - Calbiochem Struktur
CAS-Nr.
Englisch Name:
Arp2/3 Complex Inhibitor II, CK-869 - Calbiochem
Synonyma:
Arp2/3 Complex Inhibitor II, CK-869 - Calbiochem
CBNumber:
CB14816882
Summenformel:
Molgewicht:
0
MOL-Datei:
Mol file

Arp2/3 Complex Inhibitor II, CK-869 - Calbiochem Eigenschaften

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Arp2/3 Complex Inhibitor II, CK-869 - Calbiochem Chemische Eigenschaften,Einsatz,Produktion Methoden

Allgemeine Beschreibung

A cell-permeable thiazolidinone compound that inhibits actin assembly mediated by actin-related protein Arp2/3 complex of human and bovine, but not yeast, species (IC50 = 11 μM against bovine Arp2/3). Shown to inhibit the actin filament "comet tails" formation around intracellular Listeria in infected SKOV3 cells (IC50 = 7 μM). Structrual studies indicate that CK-869 targets the hydrophobic core in subdomain 1 of Arp3. CK-666 (Cat. No. 182515) and CK-869 exhibit different modes of binding, resulting in their different yeast cross-reactivities. Supplied as a racemic mixture of the active 2S and the inactive 2R enantiomers. CK-312 (Cat. No. 182518) can serve as a negative control.

Arp2/3 Complex Inhibitor II, CK-869 - Calbiochem Upstream-Materialien And Downstream Produkte

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