Arp2/3 Complex Inhibitor II, CK-869 - Calbiochem 속성
안전
Arp2/3 Complex Inhibitor II, CK-869 - Calbiochem C화학적 특성, 용도, 생산
일반 설명
A cell-permeable thiazolidinone compound that inhibits actin assembly mediated by actin-related protein Arp2/3 complex of human and bovine, but not yeast, species (IC50 = 11 μM against bovine Arp2/3). Shown to inhibit the actin filament "comet tails" formation around intracellular Listeria in infected SKOV3 cells (IC50 = 7 μM). Structrual studies indicate that CK-869 targets the hydrophobic core in subdomain 1 of Arp3. CK-666 (Cat. No. 182515) and CK-869 exhibit different modes of binding, resulting in their different yeast cross-reactivities. Supplied as a racemic mixture of the active 2S and the inactive 2R enantiomers. CK-312 (Cat. No. 182518) can serve as a negative control.
Arp2/3 Complex Inhibitor II, CK-869 - Calbiochem 준비 용품 및 원자재
원자재
준비 용품
Arp2/3 Complex Inhibitor II, CK-869 - Calbiochem 공급 업체
