Arp2/3 Complex Inhibitor II, CK-869 - Calbiochem
- CAS No.
- Chemical Name:
- Arp2/3 Complex Inhibitor II, CK-869 - Calbiochem
- Synonyms
- Arp2/3 Complex Inhibitor II, CK-869 - Calbiochem
- CBNumber:
- CB14816882
- Molecular Formula:
- Molecular Weight:
- 0
- MDL Number:
- MOL File:
- Mol file
Arp2/3 Complex Inhibitor II, CK-869 - Calbiochem Chemical Properties,Uses,Production
General Description
A cell-permeable thiazolidinone compound that inhibits actin assembly mediated by actin-related protein Arp2/3 complex of human and bovine, but not yeast, species (IC50 = 11 μM against bovine Arp2/3). Shown to inhibit the actin filament "comet tails" formation around intracellular Listeria in infected SKOV3 cells (IC50 = 7 μM). Structrual studies indicate that CK-869 targets the hydrophobic core in subdomain 1 of Arp3. CK-666 (Cat. No. 182515) and CK-869 exhibit different modes of binding, resulting in their different yeast cross-reactivities. Supplied as a racemic mixture of the active 2S and the inactive 2R enantiomers. CK-312 (Cat. No. 182518) can serve as a negative control.
Arp2/3 Complex Inhibitor II, CK-869 - Calbiochem Preparation Products And Raw materials
Raw materials
Preparation Products
Arp2/3 Complex Inhibitor II, CK-869 - Calbiochem Suppliers
Global( 2)Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
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Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51471 | 80 |
Supplier | Advantage |
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Sigma-Aldrich | 80 |
Arp2/3 Complex Inhibitor II, CK-869 - Calbiochem