Butenafine

Butenafine Struktur
101828-21-1
CAS-Nr.
101828-21-1
Englisch Name:
Butenafine
Synonyma:
But·Nafine;BUTENAFINE;Butenafine USP/EP/BP;4-tert-Butylbenzylmethyl 1-naphtylmethylamine;(4-tert-butylbenzyl)-methyl-(1-naphthylmethyl)amine;N-methyl-N-(4-methylbenzyl)-N-(1-naphthylmethyl)amine;N-(4-tert-Butylbenzyl)-N-methyl-1-naphthalenemethanamine;n-(p-tert-butylbenzyl)-n-methyl-1-naphthalenemethylamine;1-(4-tert-butylphenyl)-N-methyl-N-(naphthalen-1-ylmethyl)methanamine;n-methyl-n-(naphthalen-1-ylmethyl)-1-(4-tert-butylphenyl)methanamine
CBNumber:
CB1742475
Summenformel:
C23H27N
Molgewicht:
317.47
MOL-Datei:
101828-21-1.mol

Butenafine Eigenschaften

Schmelzpunkt:
200-202 °C
Siedepunkt:
426.1±14.0 °C(Predicted)
Dichte
1.032±0.06 g/cm3(Predicted)
storage temp. 
Store at -20°C
Löslichkeit
DMSO: 63 mg/mL (198.44 mM);Ethanol: 63 mg/mL (198.44 mM)
pka
7.87±0.50(Predicted)
Wasserlöslichkeit
Water: Insoluble
LogP
6.770 (est)
CAS Datenbank
101828-21-1(CAS DataBase Reference)

Sicherheit

Butenafine Chemische Eigenschaften,Einsatz,Produktion Methoden

Verwenden

Butenafine (Mentax) is a synthetic benzylamine antifungal agent, related structurally and pharmacologically to terbinafine. It is thought to act by inhibiting the enzyme squalene 2,3-epoxidase, resulting in decreased ergosterol and corresponding increase in squalene, with subsequent cell membrane permeability alteration and cell death. It is active against dermatophytes, yeast, and Sporothrix.
Butenafine (Mentax)

Definition

ChEBI: Trimethylamine in which hydrogen atoms attached to different methyl groups are substituted by 1-naphthyl and 4-tert-butylphenyl groups. It is an inhibitor of squalene epoxidase, an enzyme responsible for the creation of sterols needed in funga cell membranes, and is used as its hydrochloride salt for treatment of dermatological fungal infections.

Trademarks

Lotrimin (Schering); Mentax (Mylan Bertek).

Butenafine Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Butenafine Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 109)Lieferanten
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101828-21-1()Verwandte Suche:


  • n-methyl-n-(naphthalen-1-ylmethyl)-1-(4-tert-butylphenyl)methanamine
  • n-(p-tert-butylbenzyl)-n-methyl-1-naphthalenemethylamine
  • N-methyl-N-(4-methylbenzyl)-N-(1-naphthylmethyl)amine
  • 4-tert-Butylbenzylmethyl 1-naphtylmethylamine
  • N-(4-tert-Butylbenzyl)-N-methyl-1-naphthalenemethanamine
  • (4-tert-butylbenzyl)-methyl-(1-naphthylmethyl)amine
  • BUTENAFINE
  • 1-(4-tert-butylphenyl)-N-methyl-N-(naphthalen-1-ylmethyl)methanamine
  • 1-NaphthaleneMethanaMine,N-[[4-(1,1-diMethylethyl)phenyl]Methyl]-N-Methyl-
  • But·Nafine
  • Butenafine USP/EP/BP
  • 101828-21-1
  • 92-12-0
  • C23H27N
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