6-Cyclohexyl-1-hydroxy-4-methylpyridin-2(1H)-on, Verbindung mit 2-Aminoethanol (1:1) Chemische Eigenschaften,Einsatz,Produktion Methoden
R-Sätze Betriebsanweisung:
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
R42/43:Sensibilisierung durch Einatmen und Hautkontakt möglich.
R20/22:Gesundheitsschädlich beim Einatmen und Verschlucken.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
S22:Staub nicht einatmen.
Chemische Eigenschaften
White or pale yellow, crystalline powder.
Verwenden
Ciclopirox ethanolamine is a broad spectrum antimycotic agent with some antibacterial activity.
Definition
ChEBI: The ethanolamine salt of ciclopirox. A broad spectrum antigfungal agent, it also exhibits antibacterial activity against many Gram-positive and Gram-negative bacteria, and has anti-inflammatory properties. It is used a a topical treatment of fungal skin an
nail infections.
Indications
Ciclopirox olamine (Loprox, Penlac) is a synthetic, broad-spectrum hydroxypyridone
antifungal agent. It is chemically unrelated to the imidazoles or
any other antifungal agent currently available in the United States. It appears
to act through intracellular depletion of substrates and/or ions principally
by inhibition of transmembrane transport of these substances. It is active
against dermatophytes, yeast, and Pityrosporum orbiculare. It also demonstrates
activity against Trichomonas vaginalis, some mycoplasma, and some
gram-positive and gram-negative bacteria.
Clinical Use
6-Cyclohexyl-1-hydroxyl-4-methyl-2(1H)-pyridinoneethanolamine salt (Loprox) is a broad-spectrum antifungalagent intended only for topical use. It is active against dermatophytesas well as pathogenic yeasts (C. albicans) thatare causative agents for superficial fungal infections.
Ciclopirox is considered an agent of choice in the treatmentof cutaneous candidiasis, tinea corporis, tinea cruris,tinea pedis, and tinea versicolor. It is a second-line agent forthe treatment of onychomycosis (ringworm of the nails).Loprox is formulated as a cream and a lotion, each containing1% of the water-soluble ethanolamine salt. Ciclopirox isbelieved to act on cell membranes of susceptible fungi atlow concentrations to block the transport of amino acids intothe cells. At higher concentrations, membrane integrity islost, and cellular constituents leak out.
Sicherheitsprofil
Poison by intravenous andintraperitoneal routes. Moderately toxic by ingestion andsubcutaneous routes. Experimental reproductive effects.When heated to decomposition it emits toxic fumes ofNOx.
6-Cyclohexyl-1-hydroxy-4-methylpyridin-2(1H)-on, Verbindung mit 2-Aminoethanol (1:1) Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
