1-DEOXYMANNOJIRIMYCIN HYDROCHLORIDE

1-DEOXYMANNOJIRIMYCIN HYDROCHLORIDE Struktur
73465-43-7
CAS-Nr.
73465-43-7
Englisch Name:
1-DEOXYMANNOJIRIMYCIN HYDROCHLORIDE
Synonyma:
DMM;DMJ;DMJ, HYDROCHLORIDE;DEOXYMANNOJIRIMYCIN HCL;1-DeoxymannojirimycineHCl;1-DEOXYMANNOJIRIMYCIN HCL;DEOXYMANNONOJIRIMYCIN HCL;DEOXYMANNOJIRIMYCIN, HYDROCHLORIDE;1-DEOXYMANNOJIRIMYCIN HYDROCHLORIDE;1-Deoxymannojirimycinehydrochloride
CBNumber:
CB1768822
Summenformel:
C6H14ClNO4
Molgewicht:
199.63
MOL-Datei:
73465-43-7.mol

1-DEOXYMANNOJIRIMYCIN HYDROCHLORIDE Eigenschaften

Schmelzpunkt:
183-185°C
storage temp. 
Inert atmosphere,Store in freezer, under -20°C
Löslichkeit
H2O: soluble10mg/mL
Aggregatzustand
Powder
Farbe
white to off-white
Wasserlöslichkeit
Soluble in water (50 mM)
Stabilität:
Stable for 1 year from date of purchase as supplied. Solutions in distilled water may be stored at -20°C for up to 2 months.
CAS Datenbank
73465-43-7

Sicherheit

Kennzeichnung gefährlicher Xn,Xi
R-Sätze: 20/21/22-36/37/38
S-Sätze: 22-24/25-36-37/39-26
WGK Germany  3
HS Code  2941900000

1-DEOXYMANNOJIRIMYCIN HYDROCHLORIDE Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:

R20/21/22:Gesundheitsschädlich beim Einatmen,Verschlucken und Berührung mit der Haut.
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.

S-Sätze Betriebsanweisung:

S22:Staub nicht einatmen.
S24/25:Berührung mit den Augen und der Haut vermeiden.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
S37/39:Bei der Arbeit geeignete Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.

Beschreibung

1-Deoxymannojirimycin is a specific inhibitor of class I α-1,2-mannosidase (IC50 = 0.02 μM), a key enzyme for N-glycan processing in the endoplasmic reticulum and Golgi and for targeting misfolded proteins for translocation out of the endoplasmic reticulum and degradation by the proteasome. By inhibiting α-1,2-mannosidase activity, this compound generates N-linked oligosaccharides with high mannose content, preventing misfolded protein degradation. This compound has been used for studies on glycoprotein processing and as a model for the development of anticancer and antiviral therapies.

Chemische Eigenschaften

White Crystalline Solid

Verwenden

Deoxymannojirimycin has been shown to be a potent inhibitor of the mammalian Golgi alpha- mannosidase 1 activity, blocking the conversion of high-mannose oligosaccharides to complex-type oligosaccharides. However, it does not inhibit the biosynthesis of lipid- linked oligosaccharides.

1-DEOXYMANNOJIRIMYCIN HYDROCHLORIDE Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


1-DEOXYMANNOJIRIMYCIN HYDROCHLORIDE Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 103)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Hubei Jusheng Technology Co.,Ltd.
18871490254
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Dideu Industries Group Limited
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+86-27-59207850 +86-13986145403
info@fortunachem.com China 5981 58
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+86-057181025280; +8617767106207
sales@molcore.com China 49739 58
Aladdin Scientific
+1-833-552-7181
sales@aladdinsci.com United States 35748 58
Amadis Chemical Company Limited
571-89925085
sales@amadischem.com China 132020 58
J & K SCIENTIFIC LTD. 010-82848833 400-666-7788
jkinfo@jkchemical.com China 96815 76
3B Pharmachem (Wuhan) International Co.,Ltd. 821-50328103-801 18930552037
3bsc@sina.com China 15848 69

73465-43-7()Verwandte Suche:


  • 1,5-DIDEOXY-1,5-IMINO-D-MANNITOL, HCL
  • 1,5-DIDEOXY-1,5-IMINO-D-MANNITOL HYDROCHLORIDE
  • 1-DEOXYMANNOJIRIMYCIN HCL
  • (+)-1-DEOXYMANNOJIRIMYCIN HYDROCHLORIDE
  • 1-DEOXYMANNOJIRIMYCIN HYDROCHLORIDE
  • (2R,3R,4R,5R)-2-(HYDROXYMETHYL)-3,4,5-PIPERIDINETRIOL HYDROCHLORIDE
  • 1-DeoxymannojirimycineHCl
  • 1-Deoxymannojirimycinehydrochloride
  • 3,4,5-Piperidinetriol, 2-(hydroxymethyl)-, hydrochloride, (2R,3R,4R,5R)-
  • 1-Deoxymannojirimycin hydrochloride min. 98%
  • DMJ HCl, (2R,3R,4R,5R)-2-(Hydroxymethyl)-3,4,5-piperidinetriol hydrochloride
  • Manno-1-deoxynojiriMycin Hydrochloride
  • DMJ, HYDROCHLORIDE
  • DEOXYMANNOJIRIMYCIN HCL
  • DEOXYMANNOJIRIMYCIN, HYDROCHLORIDE
  • DEOXYMANNONOJIRIMYCIN HCL
  • 1-DEOXYMANNOJIRIMYCIN HYDROCHLORIDE USP/EP/BP
  • DMJ
  • DMM
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