1-DEOXYMANNOJIRIMYCIN HYDROCHLORIDE
- CAS No.
- 73465-43-7
- Chemical Name:
- 1-DEOXYMANNOJIRIMYCIN HYDROCHLORIDE
- Synonyms
- DMM;DMJ;DMJ, HYDROCHLORIDE;DEOXYMANNOJIRIMYCIN HCL;1-DeoxymannojirimycineHCl;1-DEOXYMANNOJIRIMYCIN HCL;DEOXYMANNONOJIRIMYCIN HCL;DEOXYMANNOJIRIMYCIN, HYDROCHLORIDE;1-DEOXYMANNOJIRIMYCIN HYDROCHLORIDE;1-Deoxymannojirimycinehydrochloride
- CBNumber:
- CB1768822
- Molecular Formula:
- C6H14ClNO4
- Molecular Weight:
- 199.63
- MDL Number:
- MFCD00083611
- MOL File:
- 73465-43-7.mol
- MSDS File:
- SDS
| Melting point | 183-185°C |
|---|---|
| storage temp. | Inert atmosphere,Store in freezer, under -20°C |
| solubility | H2O: soluble10mg/mL |
| form | Powder |
| color | white to off-white |
| Water Solubility | Soluble in water (50 mM) |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in distilled water may be stored at -20°C for up to 2 months. |
| CAS DataBase Reference | 73465-43-7 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302+H312+H332 | |||||||||
| Precautionary statements | P261-P264-P280-P301+P312-P302+P352+P312-P304+P340+P312 | |||||||||
| Hazard Codes | Xn,Xi | |||||||||
| Risk Statements | 20/21/22-36/37/38 | |||||||||
| Safety Statements | 22-24/25-36-37/39-26 | |||||||||
| WGK Germany | 3 | |||||||||
| HS Code | 2941900000 | |||||||||
| NFPA 704 |
|
1-DEOXYMANNOJIRIMYCIN HYDROCHLORIDE price More Price(29)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | D9160 | 1-Deoxymannojirimycin hydrochloride | 73465-43-7 | 1mg | $144 | 2024-03-01 | Buy |
| Sigma-Aldrich | D9160 | 1-Deoxymannojirimycin hydrochloride | 73465-43-7 | 5mg | $231 | 2024-03-01 | Buy |
| Alfa Aesar | J61277 | (+)-1-Deoxymannojirimycin hydrochloride | 73465-43-7 | 5mg | $143.65 | 2024-03-01 | Buy |
| Alfa Aesar | J61277 | (+)-1-Deoxymannojirimycin hydrochloride | 73465-43-7 | 10mg | $236.65 | 2024-03-01 | Buy |
| Cayman Chemical | 17178 | 1-Deoxymannojirimycin (hydrochloride) ≥98% | 73465-43-7 | 1mg | $28 | 2024-03-01 | Buy |
1-DEOXYMANNOJIRIMYCIN HYDROCHLORIDE Chemical Properties,Uses,Production
Description
1-Deoxymannojirimycin is a specific inhibitor of class I α-1,2-mannosidase (IC50 = 0.02 μM), a key enzyme for N-glycan processing in the endoplasmic reticulum and Golgi and for targeting misfolded proteins for translocation out of the endoplasmic reticulum and degradation by the proteasome. By inhibiting α-1,2-mannosidase activity, this compound generates N-linked oligosaccharides with high mannose content, preventing misfolded protein degradation. This compound has been used for studies on glycoprotein processing and as a model for the development of anticancer and antiviral therapies.
Chemical Properties
White Crystalline Solid
Uses
Deoxymannojirimycin has been shown to be a potent inhibitor of the mammalian Golgi alpha- mannosidase 1 activity, blocking the conversion of high-mannose oligosaccharides to complex-type oligosaccharides. However, it does not inhibit the biosynthesis of lipid- linked oligosaccharides.
Uses
Selective inhibitor of a-mannosidase
storage
+4°C
References
1) Bischoff et al. (1986), The use of 1-deoxymannojirimycin to evaluated the role of various alpha-mannosidases in oligosaccharide processing in intact cells; J. Biol. Chem., 261 4766 2) Bischoff et al. (1984), The effect of 1-deoxymannojirimycin on rat liver alpha mannosidases.; Biochem. Biophys. Res. Commun., 125 324 3) Fuhrmann et al. (1984), Novel mannosidase inhibitor blocking conversation of high mannose to complex oligosaccharides; Nature, 307 755 4) Miyake and Nagai (2009), Inhibition of alpha-mannosidase attenuates endoplasmic reticulum stress-induced neuronal cell death; Neurotoxicology, 30 144 5) Tai et al. (2011), Production of lentiviral vectors with enhanced efficiency to target dendritic cells by attenuating mannosidase activity of mammalian? cells; J. Biol. Eng., 5? 1 6) Lee et al. (2012), Construction of stable producer cells to make high-titer lentiviral vectors for dendritic cell-based vaccination; Biotechnol. Bioeng., 109 1551
1-DEOXYMANNOJIRIMYCIN HYDROCHLORIDE Preparation Products And Raw materials
Raw materials
Preparation Products
1-DEOXYMANNOJIRIMYCIN HYDROCHLORIDE Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28180 | 58 |
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19553 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 29016 | 58 |
| Wuhan Fortuna Chemical Co., Ltd | +86-27-59207850 +86-13986145403 | info@fortunachem.com | China | 5989 | 58 |
| Hangzhou MolCore BioPharmatech Co.,Ltd. | +86-057181025280; +8617767106207 | sales@molcore.com | China | 49739 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131981 | 58 |
| J & K SCIENTIFIC LTD. | 010-82848833 400-666-7788 | jkinfo@jkchemical.com | China | 96815 | 76 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 821-50328103-801 18930552037 | 3bsc@sina.com | China | 15848 | 69 |
View Lastest Price from 1-DEOXYMANNOJIRIMYCIN HYDROCHLORIDE manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2023-02-16 | 1-DeoxyMannojiriMycin hydrochloride
73465-43-7
|
US $0.00 / G | 10G | 98%min | 30kg/month | WUHAN FORTUNA CHEMICAL CO., LTD |
-
- 1-DeoxyMannojiriMycin hydrochloride
73465-43-7
- US $0.00 / G
- 98%min
- WUHAN FORTUNA CHEMICAL CO., LTD
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