Norgestimate
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- CAS-Nr.
- 35189-28-7
- Englisch Name:
- Norgestimate
- Synonyma:
- D-138;orf10131;Norgestimat;NORGESTIMATE;Norgestimate CRS;NorgestimateUsp27;dexnorgestrelacetime;Norgestimate (200 mg);Norgestimate USP/EP/BP;Norgestimate (1471914)
- CBNumber:
- CB2110884
- Summenformel:
- C23H31NO3
- Molgewicht:
- 369.5
- MOL-Datei:
- 35189-28-7.mol
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Norgestimate Eigenschaften
- Schmelzpunkt:
- 216°C
- alpha
- D25 +110°
- Siedepunkt:
- 497.9±45.0 °C(Predicted)
- Dichte
- 1.22±0.1 g/cm3(Predicted)
- storage temp.
- Hygroscopic, -20°C Freezer, Under Inert Atmosphere
- Löslichkeit
- DMSO: soluble5mg/mL (clear solution)
- Aggregatzustand
- powder
- pka
- 12.21±0.60(Predicted)
- Farbe
- white to beige
- Optische Aktivität
- [α]/D 43±3°, c = 1 in chloroform
- BRN
- 6440219
- Stabilität:
- Hygroscopic
- CAS Datenbank
- 35189-28-7
- EPA chemische Informationen
- 18,19-Dinorpregn-4-en-20-yn-3-one, 17-(acetyloxy)-13-ethyl-, 3-oxime, (17.alpha.)- (35189-28-7)
Sicherheit
- Risiko- und Sicherheitserklärung
- Gefahreninformationscode (GHS)
| Bildanzeige (GHS) |
 
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| Alarmwort |
Warnung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H302 |
Gesundheitsschädlich bei Verschlucken. |
Akute Toxizität oral |
Kategorie 4 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P270, P301+P312, P330, P501 |
| H315 |
Verursacht Hautreizungen. |
Hautreizung |
Kategorie 2 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P280, P302+P352, P321,P332+P313, P362 |
| H319 |
Verursacht schwere Augenreizung. |
Schwere Augenreizung |
Kategorie 2 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P280, P305+P351+P338,P337+P313P |
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| Sicherheit |
| P201 |
Vor Gebrauch besondere Anweisungen einholen. |
| P302+P352 |
BEI BERÜHRUNG MIT DER HAUT: Mit viel Wasser/... (Hersteller kann, falls zweckmäßig, ein Reinigungsmittel angeben oder, wenn Wasser eindeutig ungeeignet ist, ein alternatives Mittel empfehlen) waschen. |
| P305+P351+P338 |
BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach Möglichkeit entfernen. Weiter spülen. |
| P308+P313 |
BEI Exposition oder falls betroffen: Ärztlichen Rat einholen/ärztliche Hilfe hinzuziehen. |
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Norgestimate Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
Norgestimate is an orally-effective
progestogen, recently launched in combination with ethinyl estradiol as an oral contraceptive.
Chemische Eigenschaften
White Crystalline Solid
Allgemeine Beschreibung
Norgestimate, (17α)-17-acetyloxy-13-ethyl-18,19-dinor-pregn-4-en-20yn-3-one oxime, is a 19-nortestosterone, 3-oxime prodrug that is orally active andused with an estrogen in oral contraceptive products. It hasminimal androgenic action. Norgestimate is metabolized to17-deacetylnorgestimate (norelgestromin) and norgestrel,which provide the progestational action.
Stoffwechsel
Norgestimate is considered to be a pro-proges tin (prodrug), because it rapidly undergoes a two-s tep m etabolic transformation to form two active products, norelgestromine (levonorgestrel 3-oxime) and levonorgestrel. Deacetylation occurs in the intestine and liver, whereas convers ion of the 3-oxime to the corresponding ketone occurs primarily in the liver. Unlike the other progestins mentioned, norgestimate and its metabolites are not bound to SHBG.
Norgestimate Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Norgestimate Anbieter Lieferant Produzent Hersteller Vertrieb Händler.
Global( 155)Lieferanten
35189-28-7()Verwandte Suche:
- 13-ethyl-17-ethynyl-3-hydroxyimino-1,2,6,7,8,9,10,11,12,14,15,16-dodecahydrocyclopenta[a]phenanthren-17-yl acetate
- (17R)-17-(Acetyloxy)-13-ethyl-18,19-dinorpregn-4-en-20-yn-3-one oxime
- Norgestimate (200 mg)
- (17α)-17-(Acetyloxy)-13-ethyl-18,19-dinorpregn-4-en-20-yn-3-one 3-OxiMe
- (17a)-17-(Acetyloxy)-13-ethyl-18,19-dinorpregn-4-en-20-yn-3-one 3-Oxime
- D-138
- (17-alpha)-17-(acetyloxy)-13-ethyl-18,19-dinorpregn-4-en-20-yn-3-one3-oxime
- 18,19-dinorpregn-4-en-20-yn-3-one,17-(acetyloxy)-13-ethyl-,3-oxime,(17-alpha
- 19-dinorpregn-4-en-20-yn-3-one,17-(acetyloxy)-13-ethyl-,3-oxime,(17-alpha)-1
- d-13-beta-ethyl-17-alpha-ethynyl-17-beta-acetoxygon-4-en-3-oneoxime
- dexnorgestrelacetime
- orf10131
- NORGESTIMATE
- Norgestimat
- NORGESTIMATE, USP STANDARD
- NorgestimateUsp27
- acetic acid [(3E,8R,9S,10R,13S,14S,17R)-13-ethyl-17-ethynyl-3-hydroxyimino-1,2,6,7,8,9,10,11,12,14,15,16-dodecahydrocyclopenta[a]phenanthren-17-yl] ester
- Norgestimate for system suitability CRS
- Norgestimate CRS
- Norgestimate (Mixture of Z and E Isomers)
- 18,19-Dinorpregn-4-en-20-yn-3-one, 17-(acetyloxy)-13-ethyl-, 3-oxime, (17α)-
- (8R,9S,10R,12R,14S,17S)-12-ethyl-17-ethynyl-3-(hydroxyimino)-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl acetate
- Norgestimate USP/EP/BP
- NorgestimateQ: What is
Norgestimate Q: What is the CAS Number of
Norgestimate Q: What is the storage condition of
Norgestimate Q: What are the applications of
Norgestimate
- 35189-28-7 Norgestimate
- Norgestimate (1471914)
- 4-ESTREN-17α- ETHYNYL-18-HOMO-17β- OL-3-ONE(-)-ACETATE-OXIME
- (8R,9S,10R,13S,14S,17R)-13-ethyl-17-ethynyl-3-(hydroxyimino)-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl acetate
- 35189-28-7
- 25189-28-7
- C23H31NO3
- Metabolite Reference Standard
- Isotopically Labeled Pharmaceutical Reference Standard
- VAGISTAT
- Hormone
- Intermediates & Fine Chemicals
- Pharmaceuticals
- Steroids
