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Ethyl-4-hydroxybenzoat Produkt Beschreibung

Ethylparaben Struktur
120-47-8
CAS-Nr.
120-47-8
Bezeichnung:
Ethyl-4-hydroxybenzoat
Englisch Name:
Ethylparaben
Synonyma:
Ethyl;Sobrol A;nipazina;solbrola;Of ethyl;Solbro A;Easeptol;Keloform;Mycocten;napagina
CBNumber:
CB5119772
Summenformel:
C9H10O3
Molgewicht:
166.17
MOL-Datei:
120-47-8.mol

Ethyl-4-hydroxybenzoat Eigenschaften

Schmelzpunkt:
114-117 °C (lit.)
Siedepunkt:
297-298 °C (lit.)
Dichte
1.1708 (rough estimate)
Dampfdruck
0.00012 hPa (25 °C)
Brechungsindex
1.5286 (estimate)
Flammpunkt:
297-298°C
storage temp. 
2-8°C
Löslichkeit
Very slightly soluble in water, freely soluble in ethanol (96 per cent) and in methanol.
Aggregatzustand
Crystalline Powder
pka
8.31±0.13(Predicted)
Farbe
White
PH
4.5-5.5 (H2O, 20°C) (saturated solution)
Wasserlöslichkeit
Slightly soluble in water.
Merck 
14,3837
BRN 
1101972
Stabilität:
Stable. Combustible. Incompatible with strong oxidizing agents, strong bases.
CAS Datenbank
120-47-8(CAS DataBase Reference)
NIST chemische Informationen
Ethylparaben(120-47-8)
EPA chemische Informationen
Ethylparaben (120-47-8)
Sicherheit
  • Risiko- und Sicherheitserklärung
  • Gefahreninformationscode (GHS)
Kennzeichnung gefährlicher Xi
R-Sätze: 36/37/38
S-Sätze: 26-36-24/25
WGK Germany  1
RTECS-Nr. DH2190000
Selbstentzündungstemperatur 495 °C
TSCA  Yes
HS Code  29182930
Giftige Stoffe Daten 120-47-8(Hazardous Substances Data)
Toxizität LD50 orally in Rabbit: > 2000 mg/kg
Bildanzeige (GHS)
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H303 May be harmfulif swallowed Acute toxicity,oral Category 5 P312
H315 Verursacht Hautreizungen. Hautreizung Kategorie 2 Warnung P264, P280, P302+P352, P321,P332+P313, P362
H317 Kann allergische Hautreaktionen verursachen. Sensibilisierung der Haut Kategorie 1A Warnung P261, P272, P280, P302+P352,P333+P313, P321, P363, P501
H319 Verursacht schwere Augenreizung. Schwere Augenreizung Kategorie 2 Warnung P264, P280, P305+P351+P338,P337+P313P
Sicherheit
P261 Einatmen von Staub vermeiden.
P264 Nach Gebrauch gründlich waschen.
P264 Nach Gebrauch gründlich waschen.
P272 Kontaminierte Arbeitskleidung nicht außerhalb des Arbeitsplatzes tragen.
P280 Schutzhandschuhe/Schutzkleidung/Augenschutz tragen.
P501 Inhalt/Behälter ... (Entsorgungsvorschriften vom Hersteller anzugeben) zuführen.

Ethyl-4-hydroxybenzoat Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:

R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.

S-Sätze Betriebsanweisung:

S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
S24/25:Berührung mit den Augen und der Haut vermeiden.

Chemische Eigenschaften

white crystalline powder

Chemische Eigenschaften

Ethylparaben occurs as a white, odorless or almost odorless, crystalline powder.

Verwenden

An antimicrobial

Verwenden

bronchodilator, tocolytic

Verwenden

Preservative for pharmaceuticals.

Verwenden

Ethyl 4-hydroxybenzoate (ethylparaben) was used to study the?in-situderivatisation solid-phase microextraction procedure for determining parabens, related chlorophenols and triclosan in water. It is a novel sorbent for solid-phase extraction, was used to study its retention property. It has high extraction efficiency towards the compounds tested owing to the electrostatic interaction, hydrophobic interaction and hydrogen bonding.

Vorbereitung Methode

Ethylparaben is prepared by the esterification of p-hydroxybenzoic acid with ethanol (95%).

Synthesis Reference(s)

The Journal of Organic Chemistry, 39, p. 3343, 1974 DOI: 10.1021/jo00937a007

Allgemeine Beschreibung

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Pharmazeutische Anwendungen

Ethylparaben is widely used as an antimicrobial preservative in cosmetics,food products, and pharmaceutical formulations.
It may be used either alone or in combination with other paraben esters or with other antimicrobial agents. In cosmetics it is one of the most frequently used preservatives.
The parabens are effective over a wide pH range and have a broad spectrum of antimicrobial activity, although they are most effective against yeasts and molds.
Owing to the poor solubility of the parabens, paraben salts, particularly the sodium salt, are frequently used. However, this may cause the pH of poorly buffered formulations to become more alkaline.

Kontakt-Allergie

This substance is one of the parabens family. Parabens are esters formed by p-hydroxybenzoic acid and an alcohol. They are largely used as biocides in cosmetics and toiletries, medicaments, or food. They have synergistic power with other biocides. Parabens can induce allergic contact dermatitis, mainly in chronic dermatitis and wounded skin.

Sicherheit(Safety)

Ethylparaben and other parabens are widely used as antimicrobial preservatives in cosmetics, food products, and oral and topical pharmaceutical formulations.
Systemically, no adverse reactions to parabens have been reported, although they have been associated with hypersensitivity reactions. Parabens, in vivo, have also been reported to exhibit estrogenic responses in fish.(10) The WHO has set an estimated total acceptable daily intake for methyl-, ethyl-, and propylparabens at up to 10 mg/kg body-weight.
LD50 (mouse, IP): 0.52 g/kg
LD50 (mouse, oral): 3.0 g/kg

Lager

Aqueous ethylparaben solutions at pH 3–6 can be sterilized by autoclaving, without decomposition. At pH 3–6, aqueous solutions are stable (less than 10% decomposition) for up to about 4 years at room temperature, while solutions at pH 8 or above are subject to rapid hydrolysis (10% or more after about 60 days at room temperature).
Ethylparaben should be stored in a well-closed container in a cool, dry place.

Inkompatibilitäten

The antimicrobial properties of ethylparaben are considerably reduced in the presence of nonionic surfactants as a result of micellization. Absorption of ethylparaben by plastics has not been reported, although it appears probable given the behavior of other parabens. Ethylparaben is coabsorbed on silica in the presence of ethoxylated phenols. Yellow iron oxide, ultramarine blue, and aluminum silicate extensively absorb ethylparaben in simple aqueous systems, thus reducing preservative efficacy.
Ethylparaben is discolored in the presence of iron and is subject to hydrolysis by weak alkalis and strong acids.

Regulatory Status

Accepted as a food additive in Europe. Included in the FDA Inactive Ingredients Database (oral, otic, and topical preparations). Included in nonparenteral medicines licensed in the UK. Included in the Canadian List of Acceptable Non-medicinal Ingredients.

Ethyl-4-hydroxybenzoat Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Ethyl-4-hydroxybenzoat Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 555)Lieferanten
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Capot Chemical Co.,Ltd.
+86(0)13336195806 +86-571-85586718
+86-571-85864795 sales@capotchem.com China 20012 60
Shanghai Bojing Chemical Co.,Ltd.
+86-21-37122233
+86-21-37127788 Candy@bj-chem.com CHINA 497 55
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com China 22607 55
Hubei XinRunde Chemical Co., Ltd.
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02783214688 bruce@xrdchem.cn CHINA 567 55
Hefei TNJ Chemical Industry Co.,Ltd.
+86-0551-65418679
86-0551-65418697 info@tnjchem.com China 3000 55
Tianjin Zhongxin Chemtech Co., Ltd.
+8618622897568 +86-022-66880623
022-66880086 sales@tjzxchem.com China 543 58
Shanghai Zheyan Biotech Co., Ltd.
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career henan chemical co
+86-0371-55982848
sales@coreychem.com China 29954 58
Chengdu GLP biotechnology Co Ltd
13350802083 028-87075086
scglp@glp-china.com CHINA 1824 58
SHANDONG ZHI SHANG CHEMICAL CO.LTD
+86 18953170293
+86 0531-67809011 sales@sdzschem.com CHINA 2940 58

120-47-8(Ethyl-4-hydroxybenzoat)Verwandte Suche:


  • 4-Carbethoxyphenol
  • nipaginaa
  • Nipazin A
  • nipazina
  • Para-hydroxybenzoic acid ethyl ester
  • p-Carbethoxyphenol
  • p-Hydroxybenzoic ethyl ester
  • p-hydroxy-benzoicaciethylester
  • p-hydroxybenzoicethylester
  • p-Oxybenzoesaeureaethylester
  • Sobrol A
  • Solbrol A
  • solbrola
  • Tegosept E
  • ETHYLPARABEN,NF
  • 4-HYDROXYBENZOICACIDETHYLESTER(ETHYLPARABEN)
  • PARABEN,ETHYL
  • Ethyl-4-hydroxybenzoat
  • Ethyl P-Hdroxybenzoate
  • ETHYLP-HYDROXYBENZOATE/EASEPTOL
  • ETHYL-4-HYDROXYBENZOATE WITH HPLC
  • ETHYLPARABEN (ETHYL 4-HYDROXYBENZOATE)
  • 4-Hydroxybenzoic acid ethyl
  • Aceptin A
  • Sorbrol A
  • Ethyl 4-hydroxybenzoate,99%
  • Ethyl p-Hydrobenzoate
  • 2-Ethyl-4-hydroxy-benzoicacid
  • Ethyl-p-hydroxybenzoate 5g [120-47-8]
  • Ethylparaben (200 mg)
  • Of ethyl
  • Of ethyl (Ethylparaben)
  • Ethyl cheMosept
  • Solbro A
  • Ethyl 4-Hydroxybenzoate [for BiocheMical Research]
  • Ethyl Paraben (EP)
  • Ethyl p-Hydroxybenzoate (Ethylparaben)
  • Ethyl 4-Hydroxybenzoate,(S)
  • ETHYL 4-HYDROXYBENZOATE / ETHYLPARABEN
  • Ethyl 4-hydroxybenzoate, 99% 100GR
  • Easeptol
  • Ester etylowykwasu p-hydroksybenzoesowego
  • esteretylowykwasup-hydroksybenzoesowego
  • ethvlparaben
  • Ethyl
  • Ethyl para-hydroxybenzoate
  • Ethyl p-oxybenzoate
  • Ethylester kyseliny p-hydroxybenzoove
  • ethylesterkyselinyp-hydroxybenzoove
  • ethylhydroxybenzoate
  • Mekkings E
  • NSC 23514
  • Ethylparaben 4-Hydroxybenzoic Acid Ethyl Ester
  • Methylparaben Impurity 1(Ethylparaben)
  • Compound sodium acetate neper gold
  • Methyldopa impurity 1
  • ETHYL 4-HYDROXYBENZOATE
  • ethyl butex
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