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Ethylacetat Produkt Beschreibung

Ethyl acetate Struktur
141-78-6
CAS-Nr.
141-78-6
Bezeichnung:
Ethylacetat
Englisch Name:
Ethyl acetate
Synonyma:
ETOH;EtOAc;Etile;SPIRIT;Ethyle;ALCOHOL;Vinasse;Acetidin;ai3-00404;FEMA 2414
CBNumber:
CB7255315
Summenformel:
C4H8O2
Molgewicht:
88.11
MOL-Datei:
141-78-6.mol

Ethylacetat Eigenschaften

Schmelzpunkt:
−84 °C(lit.)
Siedepunkt:
76.5-77.5 °C(lit.)
Dichte
0.902 g/mL at 25 °C(lit.)
Dampfdichte
3 (20 °C, vs air)
Dampfdruck
73 mm Hg ( 20 °C)
Brechungsindex
n20/D 1.3720(lit.)
FEMA 
2414 | ETHYL ACETATE
Flammpunkt:
26 °F
storage temp. 
Store at +2°C to +25°C.
Löslichkeit
Miscible with ethanol, acetone, diethyl ether and benzene.
pka
16-18(at 25℃)
Aggregatzustand
Liquid
Wichte
0.902 (20/20℃)
Farbe
APHA: ≤10
Relative polarity
0.228
Geruch (Odor)
Pleasant fruity odor detectable at 7 to 50 ppm (mean = 18 ppm)
Explosionsgrenze
2.2-11.5%, 38°F
Odor Threshold
0.87ppm
Wasserlöslichkeit
80 g/L (20 ºC)
maximale Wellenlänge (λmax)
λ: 256 nm Amax: ≤1.00
λ: 275 nm Amax: ≤0.05
λ: 300 nm Amax: ≤0.03
λ: 325-400 nm Amax: ≤0.005
JECFA Number
27
Merck 
14,3757
BRN 
506104
Henry's Law Constant
0.39 at 5.00 °C, 0.58 at 10.00 °C, 0.85 at 15.00 °C, 1.17 at 20.00 °C, 1.58 at 25.00 °C (column stripping-UV, Kutsuna et al., 2005)
Expositionsgrenzwerte
TLV-TWA 400 ppm (~1400 mg/m3) (ACGIH, MSHA, and OSHA); IDLH 10,000 ppm (NIOSH).
Stabilität:
Stable. Incompatible with various plastics, strong oxidizing agents. Highly flammable. Vapour/air mixtures explosive. May be moisture sensitive.
InChIKey
XEKOWRVHYACXOJ-UHFFFAOYSA-N
CAS Datenbank
141-78-6(CAS DataBase Reference)
NIST chemische Informationen
Ethyl acetate(141-78-6)
EPA chemische Informationen
Ethyl acetate (141-78-6)
Sicherheit
  • Risiko- und Sicherheitserklärung
  • Gefahreninformationscode (GHS)
Kennzeichnung gefährlicher F,Xi,Xn,T
R-Sätze: 11-36-66-67-20/21/22-10-39/23/24/25-23/24/25-68/20/21/22
S-Sätze: 16-26-33-36/37-45-7-25
RIDADR  UN 1173 3/PG 2
WGK Germany  1
RTECS-Nr. AH5425000
1
Selbstentzündungstemperatur 427 °C
TSCA  Yes
HS Code  2915 31 00
HazardClass  3
PackingGroup  II
Giftige Stoffe Daten 141-78-6(Hazardous Substances Data)
Toxizität LD50 orally in rats: 11.3 ml/kg (Smyth)
Bildanzeige (GHS)
Alarmwort Achtung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H225 Flüssigkeit und Dampf leicht entzündbar. Entzündbare Flüssigkeiten Kategorie 2 Achtung P210,P233, P240, P241, P242, P243,P280, P303+ P361+P353, P370+P378,P403+P235, P501
H319 Verursacht schwere Augenreizung. Schwere Augenreizung Kategorie 2 Warnung P264, P280, P305+P351+P338,P337+P313P
H320 Causes eye irritation Serious eye damage/eye irritation Category 2B Warnung P264, P305+P351+P338,P337+P313
H336 Kann Schläfrigkeit und Benommenheit verursachen. Spezifische Zielorgan-Toxizität (einmalige Exposition) Kategorie 3 (Schläfrigkeit und Benommenheit) Warnung P261, P271, P304+P340, P312,P403+P233, P405, P501
H370 Schädigt die Organe. Spezifische Zielorgan-Toxizität (einmalige Exposition) Kategorie 1 Achtung P260, P264, P270, P307+P311, P321,P405, P501
Sicherheit
P233 Behälter dicht verschlossen halten.
P240 Behälter und zu befüllende Anlage erden.
P264 Nach Gebrauch gründlich waschen.
P264 Nach Gebrauch gründlich waschen.
P270 Bei Gebrauch nicht essen, trinken oder rauchen.
P271 Nur im Freien oder in gut belüfteten Räumen verwenden.
P303+P361+P353 BEI BERÜHRUNG MIT DER HAUT (oder dem Haar): Alle kontaminierten Kleidungsstücke sofort ausziehen. Haut mit Wasser abwaschen oder duschen.

Ethylacetat Chemische Eigenschaften,Einsatz,Produktion Methoden

ERSCHEINUNGSBILD

FARBLOSE FLüSSIGKEIT MIT CHARAKTERISTISCHEM GERUCH.

PHYSIKALISCHE GEFAHREN

Die Dämpfe sind schwerer als Luft und können sich am Boden ausbreiten. Fernzündung möglich.

CHEMISCHE GEFAHREN

Erhitzen kann zu sehr heftiger Verbrennung oder Explosion führen. Zersetzung unter Einfluss von UV-Licht, Säurenund Basen. Reagiert mit starken Oxidationsmitteln, Basen oder Säuren. Greift Aluminium und Kunststoffe an.

ARBEITSPLATZGRENZWERTE

TLV: 400 ppm (als TWA); (ACGIH 2005).
MAK: 400 ppm, 1500 mg/m? Spitzenbegrenzung: überschreitungsfaktor I(2); Schwangerschaft: Gruppe C; (DFG 2005).

AUFNAHMEWEGE

Aufnahme in den Körper durch Inhalation der Dämpfe.

INHALATIONSGEFAHREN

Beim Verdampfen bei 20°C kann schnell eine gesundheitsschädliche Kontamination der Luft eintreten.

WIRKUNGEN BEI KURZZEITEXPOSITION

WIRKUNGEN BEI KURZZEITEXPOSITION:
Die Substanz reizt die Augen und die Atemwege. Möglich sind Auswirkungen auf das Zentralnervensystem. Exposition weit oberhalb der Arbeitsplatzgrenzwerte kann zum Tod führen.

WIRKUNGEN NACH WIEDERHOLTER ODER LANGZEITEXPOSITION

Die Flüssigkeit entfettet die Haut.

LECKAGE

Gefahrenbereich verlassen! Ausgelaufene Flüssigkeit möglichst in abdichtbaren Behältern sammeln. Reste mit Sand oder inertem Absorptionsmittel aufnehmen und an einen sicheren Ort bringen. NICHT in die Kanalisation spülen. Persönliche Schutzausrüstung: Vollschutzanzug mit umgebungsluftunabhängigem Atemschutzgerät.

R-Sätze Betriebsanweisung:

R11:Leichtentzündlich.
R36:Reizt die Augen.
R66:Wiederholter Kontakt kann zu spröder oder rissiger Haut führen.
R67:Dämpfe können Schläfrigkeit und Benommenheit verursachen.
R20/21/22:Gesundheitsschädlich beim Einatmen,Verschlucken und Berührung mit der Haut.
R10:Entzündlich.
R39/23/24/25:Giftig: ernste Gefahr irreversiblen Schadens durch Einatmen, Berührung mit der Haut und durch Verschlucken.
R23/24/25:Giftig beim Einatmen, Verschlucken und Berührung mit der Haut.
R68/20/21/22:Gesundheitsschädlich: Möglichkeit irreversiblen Schadens durch Einatmen,Berührung mit der Haut und durch Verschlucken.

S-Sätze Betriebsanweisung:

S16:Von Zündquellen fernhalten - Nicht rauchen.
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S33:Maßnahmen gegen elektrostatische Aufladungen treffen.
S36/37:Bei der Arbeit geeignete Schutzhandschuhe und Schutzkleidung tragen.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn möglich, dieses Etikett vorzeigen).
S7:Behälter dicht geschlossen halten.
S25:Berührung mit den Augen vermeiden.

Aussehen Eigenschaften

C4H8O2; (Ethylacetat; Essigester; Essigether). Farblose, charakteristisch riechende Flüssigkeit.

Gefahren für Mensch und Umwelt

Leichtentzündlich. Die Dämpfe sind viel schwerer als Luft und bilden mit Luft explosionsfähige Gemische. Mit Oxidationsmittel heftige Reaktion, ggf. Entzündung möglich.
Ethylacetat besitzt in niedrigen Dampfkonzentrationen einen angenehm fruchtargtigen Geruch, in mittleren Konzentrationen schleimhautreizende, in höheren Dosen narkotische Wirkung. Dasselbe tritt nach Verschlucken ein, wobei geringe Dosen krampflösend und auf die Atmung vertiefend wirken. Die Symptome nach Inhalation sind: Kratzen im Hals, Appetitlosigkeit, Magenschmerzen , Kopfschmerzen. Bei höheren Konzentrationen, je nach aufgenommener Menge, subnarkotische bis narkotische Symptome, evtl.. Atemlähmung. Lungenödeme sind möglich. Durch entfettende Wirkung sind Hautekzeme möglich.
Schwach wassergefährdender Stoff (WGK 1).

Schutzmaßnahmen und Verhaltensregeln

Von Zündquellen fernhalten.
Nur in gut gelüfteten Bereichen verwenden.
Schutzhandschuhe nur als kurzzeitiger Spritzschutz.

Verhalten im Gefahrfall

Mit saugfähigem, inertem Material z. Rench Rapid oder Chemozorb aufnehmen. Rückstände mit viel Wasser und Netzmittel wegspülen.
Wasser, Kohlendioxid, Trockenlöschmittel, Schaum.

Erste Hilfe

Nach Augenkontakt: Bei Kontakt gründlich mit Wasser (mind. 10 Min.) spülen. Augenarzt konsultieren.
Nach Einatmen: Frischluft.
Nach Verschlucken: Sofort und wiederholt reichlich Wasser trinken. Erbrechen vermeiden (Aspirationsgefahr!). Arzt aufsuchen.
Nach Kleidungskontakt: Benetzte Kleidung sofort ausziehen.
Ersthelfer: siehe gesonderten Anschlag

Sachgerechte Entsorgung

Als Sondermüll (halogenfreie Lösungsmittel) entsorgen.

Beschreibung

Ethyl acetate (systematically, ethyl ethanoate, commonly abbreviated EtOAc or EA) is the organic compound with the formula CH3COOCH2CH3. This colorless liquid has a characteristic sweet smell (similar to pear drops) and is used in glues, nail polish removers, decaffeinating tea and coffee, and cigarettes (see list of additives in cigarettes). Ethyl acetate is the ester of ethanol and acetic acid; it is manufactured on a large scale for use as a solvent. The combined annual production in 1985 of Japan, North America, and Europe was about 400,000 tons. In 2004, an estimated 1.3M tons were produced worldwide.

Chemische Eigenschaften

Ethyl acetate has a pleasant ethereal fruity, brandy-like odor, reminiscent of pineapple, somewhat nauseating in high concentration. It has fruity sweet taste when freshly diluted in water. Ethyl acetate is probably one of the most used of all flavor chemicals by volume. Ethyl acetate is slowly decomposed by moisture and then acquires an acid status due to the acetic acid formed.

Physikalische Eigenschaften

Clear, colorless, mobile liquid with a pleasant, sweet fruity odor. Experimentally determined detection and recognition odor threshold concentrations were 23 mg/m3 (6.4 ppmv) and 48 mg/m3 (13.3 ppmv), respectively (Hellman and Small, 1974). Cometto-Mu?iz and Cain (1991) reported an average nasal pungency threshold concentration of 67,300 ppmv.

Occurrence

Although it has been reported present in some natural fruital aromas and in some distillates (rum, rum ether), it has not been reported yet as a constituent of essential oils; it has been identified also in the petals of Magnolia fuscata. Reported found in many foods including fresh and cooked apple, apricot, banana (169 ppm), sweet and sour cherry, citrus peel oils and juices, blueberry, cranberry, black currants, raspberry, blackberry, guava, passion fruit, melon, peaches, papaya, pineapple, cabbage, onion, leek, potato, tomato (3 to 6 ppm), clove, ginger, vinegar, breads, cheeses (0.2 to 0.8 ppm), butter (2 ppm), yogurt, milk, meats, cognac, beer (4 to 64 ppm), whiskies, cider, sherry, grape wines, rum, cocoa, coffee, tea, filberts, peanuts, popcorn, oats, honey, soybeans, coconut, olive oil (0.02 ppm) and olive.

Verwenden

Ethyl acetate is used primarily as a solvent and diluent, being favored because of its low cost, low toxicity, and agreeable odor. For example, it is commonly used to clean circuit boards and in some nail varnish removers (acetone and acetonitrile are also used). Coffee beans and tea leaves are decaffeinated with this solvent.It is also used in paints as an activator or hardener.[citation needed] Ethyl acetate is present in confectionery, perfumes, and fruits. In perfumes, it evaporates quickly, leaving only the scent of the perfume on the skin.
3 – 1 - Laboratory uses
In the laboratory, mixtures containing ethyl acetate are commonly used in column chromatography and extractions. Ethyl acetate is rarely selected as a reaction solvent because it is prone to hydrolysis and trans esterification.
3 – 2 - Occurrence in wines
Ethyl acetate is the most common ester in wine, being the product of the most common volatile organic acid — acetic acid, and the ethyl alcohol generated during the fermentation. The aroma of ethyl acetate is most vivid in younger wines and contributes towards the general perception of "fruitiness" in the wine.
3 – 3 - Entomological killing agent
In the field of entomology, ethyl acetate is an effective asphyxiant for use in insect collecting and study. In a killing jar charged with ethyl acetate, the vapors will kill the collected (usually adult) insect quickly without destroying it. Because it is not hygroscopic, ethyl acetate also keeps the insect soft enough to allow proper mounting suitable for a collection.

Verwenden

Ethyl acetate is used as a solvent for varnishes, lacquers, and nitrocellulose; as anartificial fruit flavor; in cleaning textiles;and in the manufacture of artificial silk andleather, perfumes, and photographic filmsand plates (Merck 1996). Ethyl Acetate is generally used as a solvent in organic reactions. Environmental contaminants; Food contaminants.

Verwenden

Pharmaceutic aid (flavor); artificial fruit essences; solvent for nitrocellulose, varnishes, lacquers, and aeroplane dopes; manufacture of smokeless powder, artificial leather, photographic films and plates, artificial silk, perfumes; cleaning textiles, etc.

Vorbereitung Methode

Ethyl acetate is synthesized in industry mainly via the classic Fischer esterification reaction of ethanol and acetic acid. This mixture converts to the ester in about 65% yield at room temperature:
CH3CH2OH + CH3COOH ? CH3COOCH2CH3 + H2O
The reaction can be accelerated by acid catalysis and the equilibrium can be shifted to the right by removal of water. It is also prepared in industry using the Tishchenko reaction, by combining two equivalents of acetaldehyde in the presence of an alkoxide catalyst:
2 CH3CHO → CH3COOCH2CH3.

Vorbereitung Methode

Ethyl acetate can be manufactured by the slow distillation of a mixture of ethanol and acetic acid in the presence of concentrated sulfuric acid. It has also been prepared from ethylene using an aluminum alkoxide catalyst.

synthetische

Ethyl acetate is made by esterification of acetic acid with ethanol, from acetaldehyde, or by the direct addition of ethylene to acetic acid. BP started a 220,000 tonne/year plant in 2001 to operate the last of these processes, known as AVADA. Ethylene and acetic acid react in the presence of a heteropolyacid catalyst to give ethyl acetate at a claimed high selectivity and 99.97% purity. This is the world’s largest ethyl acetate plant and is motivated by its increasing use as a more “acceptable” solvent than hydrocarbons.
In some countries, where ethanol is expensive or there is surplus acetaldehyde capacity, ethyl acetate is made by a Tishchenko reaction. Sasol in South Africa was said to be investigating such a process in the early 2000s. Ethanol is a solvent for surface coatings, cleaning preparations, and cosmetics. Industrial ethanol is aerobically fermented to white vinegar (dilute acetic acid) of the type used for pickling. Gourmet vinegars—wine vinegar, cider vinegar, and so on, made by fermentation of alcoholic beverages—are also available. Ten percent of industrial ethanol production was used for vinegar in the United States in 2001.

Reaktionen

Ethyl acetate can be hydrolyzed in acidic or basic conditions to regain acetic acid and ethanol. The use of an acid catalyst accelerates the hydrolysis, which is subject to the Fischer equilibrium mentioned above. In the laboratory, and usually for illustrative purposes only, ethyl esters are typically hydrolyzed in a two step process starting with a stoichiometric amount of strong base, such as sodium hydroxide. This reaction gives ethanol and sodium acetate, which is unreactive toward ethanol:
CH3CO2C2H5 + Na OH → C2H5OH + CH3CO2Na
The rate constant is 0.111 dm3 / mol.sec at 25 °C.

Aroma threshold values

Detection: 5 ppb to 5 ppm

Air & Water Reaktionen

Highly flammable. Slightly soluble in water. Ethyl acetate is slowly hydrolyzed by moisture.

Reaktivität anzeigen

Ethyl acetate is also sensitive to heat. On prolonged storage, materials containing similar functional groups have formed explosive peroxides. Ethyl acetate may ignite or explode with lithium aluminum hydride. Ethyl acetate may also ignite with potassium tert-butoxide. Ethyl acetate is incompatible with nitrates, strong alkalis and strong acids. Ethyl acetate will attack some forms of plastics, rubber and coatings. Ethyl acetate is incompatible with oxidizers such as hydrogen peroxide, nitric acid, perchloric acid and chromium trioxide. Violent reactions occur with chlorosulfonic acid. . SOCl2 reacts with esters, such as Ethyl acetate, forming toxic SO2 gas and water soluble/toxic acyl chlorides, catalyzed by Fe or Zn (Spagnuolo, C.J. et al. 1992. Chemical and Engineering News 70(22):2.).

Health Hazard

The acute toxicity of ethyl acetate is low. Ethyl acetate vapor causes eye, skin, and respiratory tract irritation at concentrations above 400 ppm. Exposure to high concentrations may lead to headache, nausea, blurred vision, central nervous system depression, dizziness, drowsiness, and fatigue. Ingestion of ethyl acetate may cause gastrointestinal irritation and, with larger amounts, central nervous system depression. Eye contact with the liquid can produce temporary irritation and lacrimation. Skin contact produces irritation. Ethyl acetate is regarded as a substance with good warning properties. No chronic systemic effects have been reported in humans, and ethyl acetate has not been shown to be a human carcinogen, reproductive, or developmental toxin

Flammability and Explosibility

Ethyl acetate is a flammable liquid (NFPA rating = 3), and its vapor can travel a considerable distance to an ignition source and "flash back." Ethyl acetate vapor forms explosive mixtures with air at concentrations of 2 to 11.5% (by volume). Hazardous gases produced in ethyl acetate fires include carbon monoxide and carbon dioxide. Carbon dioxide or dry chemical extinguishers should be used for ethyl acetate fires.

Chemische Reaktivität

Reactivity with Water No reaction; Reactivity with Common Materials: No reaction; Stability During Transport: Stable; Neutralizing Agents for Acids and Caustics: Not pertinent; Polymerization: Not pertinent; Inhibitor of Polymerization: Not pertinent.

Pharmazeutische Anwendungen

In pharmaceutical preparations, ethyl acetate is primarily used as a solvent, although it has also been used as a flavoring agent. As a solvent, it is included in topical solutions and gels, and in edible printing inks used for tablets.
Ethyl acetate has also been shown to increase the solubility of chlortalidone and to modify the polymorphic crystal forms obtained for piroxicam pivalate, mefenamic acid, and fluconazole,and has been used in the formulation of microspheres. Ethyl acetate has been used as a solvent in the preparation of a liposomal amphotericin B dry powder inhaler formulation.(9) Its use as a chemical enhancer for the transdermal iontophoresis of insulin has been investigated.
In food applications, ethyl acetate is mainly used as a flavoring agent. It is also used in artificial fruit essence and as an extraction solvent in food processing.

Sicherheitsprofil

Potentially poisonous by ingestion. Toxicity depends upon alcohols in question, generally ethanol with methanol as a denaturant. A flammable liquid and dangerous fire hazard; can react vigorously with oxidzing materials. Moderate explosion hazard. See ETHANOL, METHYL ALCOHOL, and n-PROPYL ALCOHOL.

Sicherheit(Safety)

Ethyl acetate is used in foods, and oral and topical pharmaceutical formulations. It is generally regarded as a relatively nontoxic and nonirritant material when used as an excipient.
However, ethyl acetate may be irritant to mucous membranes, and high concentrations may cause central nervous system depression. Potential symptoms of overexposure include irritation of the eyes, nose, and throat, narcosis, and dermatitis.
Ethyl acetate has not been shown to be a human carcinogen or a reproductive or developmental toxin.
The WHO has set an estimated acceptable daily intake of ethyl acetate at up to 25 mg/kg body-weight.
In the UK, it has been recommended that ethyl acetate be temporarily permitted for use as a solvent in food and that the maximum concentration consumed in food should be set at 1000 ppm.
LD50 (cat, SC): 3.00 g/kg
LD50 (guinea-pig, oral): 5.50 g/kg
LD50 (guinea-pig, SC): 3.00 g/kg
LD50 (mouse, IP): 0.709 g/kg
LD50 (mouse, oral): 4.10 g/kg
LD50 (rabbit, oral): 4.935 g/kg
LD50 (rat, oral): 5.62 g/kg

Chemical Synthesis

By reacting acetic acid and ethanol in the presence of sulfuric acid; by distillation of sodium potassium, or lead acetate with ethanol in the presence of sulfuric acid; by polymerizatin of acetaldehyde in the presence of aluminum ethylate or aluminum acetate as catalysts.

mögliche Exposition

This material is used as a solvent for nitrocellulose and lacquer. It is also used in making dyes,flavoring and perfumery, and in smokeless powder manufacture

Carcinogenicity

Ethyl acetate was not mutagenic in bacterial assays; it was not genotoxic in a number of in vivo assays but did cause chromosomal damage in hamster cells in vitro.
Ethyl acetate has a fruity odor detectable at 10ppm.
The 2003 ACGIH threshold limit valuetime- weighted average (TLV-TWA) for ethyl acetate is 400pm (1440mg/m3).

Source

Identified among 139 volatile compounds identified in cantaloupe (Cucumis melo var. reticulates cv. Sol Real) using an automated rapid headspace solid phase microextraction method (Beaulieu and Grimm, 2001).

Environmental Fate

Biological. Heukelekian and Rand (1955) reported a 5-d BOD value of 1.00 g/g which is 54.9% of the ThOD value of 1.82 g/g.
Photolytic. Reported rate constants for the reaction of ethyl acetate and OH radicals in the atmosphere (296 K) and aqueous solution are 1.51 x 10-12 and 6.60 x 10-13 cm3/molecule?sec, respectively (Wallington et al., 1988b).
Chemical/Physical. Hydrolyzes in water forming ethanol and acetic acid (Kollig, 1993). The estimated hydrolysis half-life at 25 °C and pH 7 is 2.0 yr (Mabey and Mill, 1978).

Stoffwechsel

Ethyl acetate is hydrolysed to ethyl alcohol, which is then partly excreted in the expired air and urine. The rest is metabolized, the acetate fraction becoming incor porated in the body pool (Fassett, 1963).

Lager

Ethyl acetate should be stored in an airtight container, protected from light and at a temperature not exceeding 30°C. Ethyl acetate is slowly decomposed by moisture and becomes acidic; the material can absorb up to 3.3% w/w water.
Ethyl acetate decomposes on heating to produce ethanol and acetic acid, and will emit acrid smoke and irritating fumes. It is flammable and its vapor may travel a considerable distance to an ignition source and cause a ‘flashback’.
The alkaline hydrolysis of ethyl acetate has been shown to be inhibited by polyethylene glycol and by mixed micelle systems.

Versand/Shipping

UN1173 Ethyl acetate, Hazard Class: 3; Labels: 3-Flammable liquid.

läuterung methode

The most common impurities in EtOAc are water, EtOH and acetic acid. These can be removed by washing with aqueous 5% Na2CO3, then with saturated aqueous CaCl2 or NaCl, and drying with K2CO3, CaSO4 or MgSO4. More efficient drying is achieved if the solvent is further dried with P2O5, CaH2 or molecular sieves before distillation. CaO has also been used. Alternatively, ethanol can be converted to ethyl acetate by refluxing with acetic anhydride (ca 1mL per 10mL of ester), the liquid is then fractionally distilled, dried with K2CO3 and redistilled. [Beilstein 2 III 127.]

Toxicity evaluation

Ethyl acetate is rapidly hydrolyzed to ethanol and acetic acid. When ethyl acetate was injected intraperitoneal at 1.6 g kg-1, hydrolysis to acetic acid and ethanol occurred rapidly. The biological half-life value of the conversion of ethyl acetate to ethanol was found to be between 5 and 10 min. At doses higher than 1.6 g kg-1 in rats the rate of hydrolysis exceeded the ethanol oxidation leading to the ethanol accumulation in the vascular system.

Inkompatibilitäten

Ethyl acetate can react vigorously with strong oxidizers, strong alkalis, strong acids, and nitrates to cause fires or explosions. It also reacts vigorously with chlorosulfonic acid, lithium aluminum hydride, 2-chloromethylfuran, and potassium tert-butoxide.

Waste disposal

Dissolve or mix the material with a combustible solvent and burn in a chemical incinerator equipped with an afterburner and scrubber. All federal, state, and local environmental regulations must be observed. Consult with environmental regulatory agencies for guidance on acceptable disposal practices. Generators of waste containing this contaminant (≧100 kg/ mo) must conform with EPA regulations governing storage, transportation, treatment, and waste disposal.

Regulatory Status

Included in the FDA Inactive Ingredients Database (oral tablets and sustained-action tablets; topical and transdermal preparations). Included in nonparenteral medicines licensed in the UK (tablets, topical solutions, and gels). Ethyl acetate is also accepted for use in food applications in a number of countries including the UK. Included in the Canadian List of Acceptable Non-medicinal Ingredients.

Ethylacetat Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Ethylacetat Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 119)Lieferanten
Firmenname Telefon Fax E-Mail Land Produktkatalog Edge Rate
Shandong Yanshuo Chemical Co., Ltd.
+8618678179670
+86-533-7077568 leon@yanshuochem.com China 60 58
Tianjin Zhongxin Chemtech Co., Ltd.
022-66880623
022-66880086 sales@tjzxchem.com CHINA 537 58
Hebei Guanlang Biotechnology Co., Ltd.
+8619930503282
sales3@crovellbio.com China 5930 58
Henan Xiangtong Chemical Co., Ltd.
86-371-61312303
86-371-86017988 cathy@hnxtchem.com CHINA 293 58
Shanghai Longyu Biotechnology Co., Ltd.
+8615821988213
+86 15821988213 info@longyupharma.com China 2473 58
Hubei Ipure Biology Co., Ltd
+8618062405514
18062427325 ada@ipurechemical.com;ada@ipurechemical.com China 10352 58
Hebei Ruiyao Biotechnology Co. Ltd
15532235888 15632182983
031188180881 admin@ruiyaobio.com CHINA 846 58
Connect Chemicals GmbH
+49 2102 2077-39
+49 2102 2077-40 inquiries@connectchemicals.com Germany 265 58
Wuxi Rejoys chemical Technology Co., Ltd.
0510-86103381
0510-86103381 sales@rejoyschem.com CHINA 976 58
Shanghai UCHEM Inc.
15502138767 15502138767
sales@myuchem.com CHINA 2773 58

141-78-6(Ethylacetat)Verwandte Suche:


  • AKOS BBS-00004223
  • METHYLATED SPIRIT
  • METHYLATED SPIRIT INDUSTRIAL
  • METHYLATED SPIRIT MINERALISED
  • METHYLCARBINOL
  • REAGENT ALCOHOL
  • RARECHEM AL BI 0544
  • SPIRIT OF WINE
  • SPIRIT
  • S2, ETHYL ACETATE
  • S2B, ETHYL ACETATE
  • NATURAL ETHYL ACETATE
  • VINEGAR NAPHTHA
  • UK INDUSTRIAL METHYLATED SPIRIT
  • Ethvl acetate
  • Ethyl acetate ,99.9% [ACS/HPLC certified]
  • Ethyl acetate ,99.9% [SuperPure]
  • Acetic acid ethyl
  • ETHYL ACETATE, 99+%, PURE
  • ETHYL ACETATE, 99.5+%, FOR SPECTROSCOPY
  • ETHYL ACETATE, 99.5%, FOR ANALYSIS
  • ETHYL ACETATE, 99.5%, FOR HPLC
  • ETHYL ACETATE, 99.9%, RESIDUE FREE, FOR ELECTRONIC USE
  • ETHYL ACETATE, 99.9%, WATER <50 PPM, EXTRA DRY OVER MOLECULAR SIEVE
  • ETHYL ACETATE, 99.6%, FOR ANALYSIS ACS
  • Ethyl acetate, pure
  • Ethyl acetate, for spectroscopy
  • Ethyl acetate, for analysis
  • Ethyl acetate, AcroSeal, Extra Dry
  • Ethyl acetate, residue free, for electronic use
  • Ethyl acetate, AcroSeal, Extra Dry over Molecular Sieve
  • Ethyl acetate, conform to ACS, for spectroscopy
  • Ethyl acetate, for analysis ACS
  • Ethanol, anhydrous, denatured, HPLC Grade, 90%, packaged under Argon in resealable ChemSeal^t bottle
  • Ethyl acetate,99.9%,Extra Dry over MolecularSieve
  • Ethyl acetate,99.9%,Extra Dry
  • Ethyl acetate,for residue analysis,suitable for residue and pesticides analysis
  • Ethyl acetate,99.5%,for spectroscopy,conformto ACS
  • Ethyl acetate,99.9%,for electronic use,residue free
  • MultiPharM (TM) Ethyl Acetate Extra Pure, Ph Eur, NF
  • Ethyl Acetate (1.2 mL/ampule
  • Ethyl acetate, 99.9%, Extra Dry over Molecular Sieve, AcroSeal
  • Ethyl acetate, 99.9%, Extra Dry, AcroSeal
  • Ethyl acetate, 99+%, extra pure
  • Ethyl acetate, for analysis, 99.5% 1LT
  • Ethyl acetate, for analysis, 99.5% 2.5LT
  • Ethyl acetate, for spectroscopy, 99.5+% 500ML
  • Ethyl acetate, pure, 99+% 1LT
  • Ethyl acetate, pure, 99+% 2.5LT
  • Ethyl acetate, pure, 99+% 25LT
  • Ethyl acetate, pure, 99+% 5LT
  • EtOAc
  • 1-acetoxyethane
  • ac. acetic ethyl ester
  • acetated’ethyle
  • acetated’ethyle(french)
  • acetatodeetilo
  • Acetidin
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