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Zoledronate disodium tetrahydrate Produkt Beschreibung

Zoledronate disodium tetrahydrate Struktur
165800-07-7
CAS-Nr.
165800-07-7
Englisch Name:
Zoledronate disodium tetrahydrate
Synonyma:
CGP-42446A;Disodium salt tetrahydrate;Zoledronate Disodium, CGP-42446A;ZOLEDRONATE DISODIUM, TETRAHYDRATE;Zoledronate DisodiuM (C5H8N2Na2O7P24H2O);ZOLEDRONIC ACID, DISODIUM SALT, TETRAHYDRATE;Sodium (1-hydroxy-2-(1H-imidazol-1-yl)-1-phosphonoethyl)phosphonate tetrahydrate;(1-Hydroxy-2-(1H-imidazol-1-yl)ethylidene)bisphosphonic acid disodium salt tetrahydrate
CBNumber:
CB2191764
Summenformel:
C5H16N2Na2O11P2
Molgewicht:
388.11
MOL-Datei:
165800-07-7.mol

Zoledronate disodium tetrahydrate Eigenschaften

Schmelzpunkt:
305-307°C
storage temp. 
Sealed in dry,Room Temperature

Sicherheit

Zoledronate disodium tetrahydrate Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

Zoledronate was introduced in Canada as a lyophilized powder in vials for infusion as solution in the treatment of tumor-induced hypercalcemia. This third-generation bisphosphonate can be obtained by reaction of 2-(1-imidazolyl)acetic acid hydrochloride with phosphorous trichloride followed by hydrolysis in concentrated hydrochloric acid, Zoledronate originated from a medicinal chemistry program started at Novartis, Switzerland in 1986 and aimed at discovering a follow-up to pamidronate for the treatment of osteoporosis and metastatic bone disease. It has highly potent inhibitory effect on hypercalcemia induced by vitamin Ds both in vitro in mouse calvarial cultures and in viva in the thyroparathyroidectomized rat. It is respectively 100 and 850-fold more potent than pamidronate in the former and latter tests. Clinically, it was demonstrated that zoledronate achieved normalized serum calcium concentrations in a significantly higher percentage of cancer patients compared to pamidronate. The 5 minute infusion with zoledronate was more convenient than the 2 hour infusion necessary with pamidronate.

Chemische Eigenschaften

White Crystalline Powder

Originator

Novartis (Switzerland)

Verwenden

A biphosphonate bone resorption inhibitor.

Trademarks

Zometa

Zoledronate disodium tetrahydrate Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Zoledronate disodium tetrahydrate Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 30)Lieferanten
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165800-07-7()Verwandte Suche:


  • ZOLEDRONATE DISODIUM, TETRAHYDRATE
  • ZOLEDRONIC ACID, DISODIUM SALT, TETRAHYDRATE
  • Zoledronate Disodium, CGP-42446A
  • (1-Hydroxy-2-(1H-imidazol-1-yl)ethylidene)bisphosphonic acid disodium salt tetrahydrate
  • CGP-42446A
  • Zoledronate DisodiuM (C5H8N2Na2O7P24H2O)
  • Sodium (1-hydroxy-2-(1H-imidazol-1-yl)-1-phosphonoethyl)phosphonate tetrahydrate
  • Disodium salt tetrahydrate
  • 165800-07-7
  • C5H16N2Na2O11P2
  • C5H8N2Na2O7P24H2O
  • Inhibitors
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
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