SERTINDOLE
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- CAS-Nr.
- 106516-24-9
- Englisch Name:
- SERTINDOLE
- Synonyma:
- S-1991;Zerdol;Serlect;Serdoleet;LU-23-174;Serdolect;SERTINDOLE;Sertindole>SUBSTANCE 5364890;SERTINDOLE USP/EP/BP
- CBNumber:
- CB2221267
- Summenformel:
- C24H26ClFN4O
- Molgewicht:
- 440.94
- MOL-Datei:
- 106516-24-9.mol
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SERTINDOLE Eigenschaften
- Schmelzpunkt:
- 95-100°C
- Siedepunkt:
- 592.1±50.0 °C(Predicted)
- Dichte
- 1.36
- storage temp.
- Sealed in dry,2-8°C
- Löslichkeit
- DMSO: >10mg/mL
- Aggregatzustand
- solid
- pka
- 14.53±0.20(Predicted)
- Farbe
- off-white
- Merck
- 14,8466
- InChIKey
- GZKLJWGUPQBVJQ-UHFFFAOYSA-N
SERTINDOLE Chemische Eigenschaften,Einsatz,Produktion Methoden
R-Sätze Betriebsanweisung:
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
Beschreibung
Serdolect was launched in the UK for acute and chronic schizophrenia and
schizoaffective psychoses. It is synthetically available in three steps from 5chloro-l-
(4-fluorophenyl)-l H-indole. Sertindole is selective for the limbic areas of the brain
and has a high affinity for the serotinin 5-HT
2 receptor where it behaves as an
antagonist. It has weak affinity for the α
1-adrenergic receptor and no affinity for
dopamine D
2 receptors. It is as effective as haloperidol but without the
extrapyramidal symptoms. This may be a consequence of the fact that it expresses
the c-fos protein in a manner different for haloperidol but similar to clozapine. It is
non-sedating, long lasting (several days after a single dose) and has an atypical
mode of action.
Chemische Eigenschaften
Off-White to Pale Yellow Solid
Verwenden
Antipsychotic used in the treatment of schizophrenia.
Definition
ChEBI: A phenylindole that is 1H-indole which is substituted on the nitrogen by a p-chlorophenyl group, at position 5 by chlorine, and at position 3 by a piperidin-4-yl group, which is itself substituted on the nitrogen by a 2-(2-o
oimidazolidin-1-yl)ethyl group.
Nebenwirkungen
Sertindole is an indole-containing compound that behaves as a high-affinity serotonin 5-HT2 receptor antagonist,
with weak affinity for adrenergic α1 receptors and almost no affinity for dopaminergic D2 receptors. It is about as
effective as haloperidol in the treatment of acute and chronic schizophrenia, but with much lower incidence of
extrapyramidal side effects. Sertindole is relatively nonsedating, and its effects are long lasting (several days).
SERTINDOLE Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
SERTINDOLE Anbieter Lieferant Produzent Hersteller Vertrieb Händler.
Global( 137)Lieferanten
106516-24-9()Verwandte Suche:
- SERTINDOLE
- SUBSTANCE 5364890
- 1-(2-{4-[5-CHLORO-1-(4-FLUORO-PHENYL)-1H-INDOL-3-YL]-PIPERIDIN-1-YL}-ETHYL)-IMIDAZOLIDIN-2-ONE
- 1-[2-[4-[5-Chloro-1-(4-fluorophenyl)-1h-indol-3-yl]-1-piperidinyl]ethyl]-2-imidazolidinone
- 1-(4-Fluorophenyl)-5-chloro-3-[1-[2-[(tetrahydro-2-oxo-1H-imidazol)-1-yl]ethyl]piperidin-4-yl]-1H-indole
- 1-[2-[4-[1-(4-Fluorophenyl)-5-chloro-1H-indole-3-yl]piperidino]ethyl]imidazolidine-2-one
- S-1991
- LU-23-174
- Serdoleet
- 2-IMidazolidinone, Sertindole
- 2-IMidazolidinone,1-[2-[4-[5-chloro-1-(4-fluorophenyl)-1H-indol-3-yl]-1-piperidinyl]ethyl]-
- Zerdol
- Serdolect
- SERDOLECT;SERLECT;LU 23-174
- Serlect
- Sertindole>
- SERTINDOLE USP/EP/BP
- Maribavir Impurity 15
- 106516-24-9
- C24H26ClFN4O
- C24H26ClFN3O
- C24H22D4ClFN4O
- Aluminium foil bag/Fluoride bottle or on your request
- Aromatics
- Heterocycles
- Intermediates & Fine Chemicals
- Isotope Labelled Compounds
- Pharmaceuticals
