セルチンドール
セルチンドール 物理性質
- 融点 :
- 95-100°C
- 沸点 :
- 592.1±50.0 °C(Predicted)
- 比重(密度) :
- 1.36
- 貯蔵温度 :
- Sealed in dry,2-8°C
- 溶解性:
- DMSO：>10mg/mL
- 外見 :
- 個体
- 酸解離定数(Pka):
- 14.53±0.20(Predicted)
- 色:
- オフホワイト
- Merck :
- 14,8466
- InChIKey:
- GZKLJWGUPQBVJQ-UHFFFAOYSA-N
| メーカー |
製品番号 |
製品説明 |
CAS番号 |
包装 |
価格 |
更新時間 |
購入 |
|
東京化成工業
|
S0942 |
セルチンドール >95.0%(HPLC)
Sertindole
>95.0%(HPLC) |
106516-24-9 |
10mg |
￥11400 |
2024-03-01 |
購入 |
|
東京化成工業
|
S0942 |
セルチンドール >95.0%(HPLC)
Sertindole
>95.0%(HPLC) |
106516-24-9 |
50mg |
￥40700 |
2024-03-01 |
購入 |
|
Sigma-Aldrich Japan
|
S8072 |
セルチンドール ≥97.5% (HPLC)
Sertindole ≥97.5% (HPLC) |
106516-24-9 |
10mg |
￥18700 |
2021-03-23 |
購入 |
|
Sigma-Aldrich Japan
|
S8072 |
セルチンドール ≥97.5% (HPLC)
Sertindole ≥97.5% (HPLC) |
106516-24-9 |
50mg |
￥83500 |
2021-03-23 |
購入 |
セルチンドール 化学特性,用途語,生産方法
外観
白色～ほとんど白色粉末～結晶
効能
統合失調症治療薬, 神経遮断薬
説明
Serdolect was launched in the UK for acute and chronic schizophrenia and
schizoaffective psychoses. It is synthetically available in three steps from 5chloro-l-
(4-fluorophenyl)-l H-indole. Sertindole is selective for the limbic areas of the brain
and has a high affinity for the serotinin 5-HT
2 receptor where it behaves as an
antagonist. It has weak affinity for the α
1-adrenergic receptor and no affinity for
dopamine D
2 receptors. It is as effective as haloperidol but without the
extrapyramidal symptoms. This may be a consequence of the fact that it expresses
the c-fos protein in a manner different for haloperidol but similar to clozapine. It is
non-sedating, long lasting (several days after a single dose) and has an atypical
mode of action.
化学的特性
Off-White to Pale Yellow Solid
使用
Antipsychotic used in the treatment of schizophrenia.
定義
ChEBI: A phenylindole that is 1H-indole which is substituted on the nitrogen by a p-chlorophenyl group, at position 5 by chlorine, and at position 3 by a piperidin-4-yl group, which is itself substituted on the nitrogen by a 2-(2-o
oimidazolidin-1-yl)ethyl group.
副作用
Sertindole is an indole-containing compound that behaves as a high-affinity serotonin 5-HT2 receptor antagonist,
with weak affinity for adrenergic α1 receptors and almost no affinity for dopaminergic D2 receptors. It is about as
effective as haloperidol in the treatment of acute and chronic schizophrenia, but with much lower incidence of
extrapyramidal side effects. Sertindole is relatively nonsedating, and its effects are long lasting (several days).
セルチンドール 上流と下流の製品情報
原材料
準備製品
セルチンドール 生産企業
Global( 132)Suppliers
106516-24-9(セルチンドール)キーワード:
- 106516-24-9
- SERTINDOLE
- SUBSTANCE 5364890
- 1-(2-{4-[5-CHLORO-1-(4-FLUORO-PHENYL)-1H-INDOL-3-YL]-PIPERIDIN-1-YL}-ETHYL)-IMIDAZOLIDIN-2-ONE
- 1-[2-[4-[5-Chloro-1-(4-fluorophenyl)-1h-indol-3-yl]-1-piperidinyl]ethyl]-2-imidazolidinone
- 1-(4-Fluorophenyl)-5-chloro-3-[1-[2-[(tetrahydro-2-oxo-1H-imidazol)-1-yl]ethyl]piperidin-4-yl]-1H-indole
- 1-[2-[4-[1-(4-Fluorophenyl)-5-chloro-1H-indole-3-yl]piperidino]ethyl]imidazolidine-2-one
- S-1991
- LU-23-174
- Serdoleet
- 2-IMidazolidinone, Sertindole
- 2-IMidazolidinone,1-[2-[4-[5-chloro-1-(4-fluorophenyl)-1H-indol-3-yl]-1-piperidinyl]ethyl]-
- Zerdol
- Serdolect
- SERDOLECT;SERLECT;LU 23-174
- Serlect
- Sertindole>
- SERTINDOLE USP/EP/BP
- Maribavir Impurity 15
- 1-(4-フルオロフェニル)-5-クロロ-3-[1-[2-[(テトラヒドロ-2-オキソ-1H-イミダゾール)-1-イル]エチル]ピペリジン-4-イル]-1H-インドール
- 1-[2-[4-[1-(4-フルオロフェニル)-5-クロロ-1H-インドール-3-イル]ピペリジノ]エチル]イミダゾリジン-2-オン
- セルチンドール
- 1-(4-フルオロフェニル)-5-クロロ-3-[1-[2-(2-オキソ-1-イミダゾリジニル)エチル]-4-ピペリジニル]-1H-インドール
- 1-[2-[4-[5-クロロ-1-(4-フルオロフェニル)-1H-インドール-3-イル]-1-ピペリジニル]エチル]-2-イミダゾリジノン
- 1-(2-{4-[5-クロロ-1-(4-フルオロフェニル)-1H-インドール-3-イル]ピペリジン-1-イル}エチル)イミダゾリジン-2-オン
- 向精神薬