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N-[3-[[5-Cyclopropyl-2-[[3-(4-morpholinylmethyl)phenyl]amino]-4-pyrimidinyl]amino]propyl]cyclobutanecarboxamide

N-[3-[[5-Cyclopropyl-2-[[3-(4-morpholinylmethyl)phenyl]amino]-4-pyrimidinyl]amino]propyl]cyclobutanecarboxamide Struktur
1190378-57-4
CAS-Nr.
1190378-57-4
Englisch Name:
N-[3-[[5-Cyclopropyl-2-[[3-(4-morpholinylmethyl)phenyl]amino]-4-pyrimidinyl]amino]propyl]cyclobutanecarboxamide
Synonyma:
CS-2840;MRT68921;MRT67307;MRT67307 HCl;MRT67307 (MRT 67307;MRT67307 (free base);MRT67307 hydrochloride;MRT67307 HCl(free-base);MRT67307, 10 mM in DMSO;IKKε/TBK1 Inhibitor II, MRT67307
CBNumber:
CB22547040
Summenformel:
C26H36N6O2
Molgewicht:
464.6
MOL-Datei:
1190378-57-4.mol
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N-[3-[[5-Cyclopropyl-2-[[3-(4-morpholinylmethyl)phenyl]amino]-4-pyrimidinyl]amino]propyl]cyclobutanecarboxamide Eigenschaften

Dichte
1.270
storage temp. 
Keep in dark place,Sealed in dry,2-8°C
Löslichkeit
H2O: soluble15mg/mL, clear
Aggregatzustand
powder
pka
15.94±0.20(Predicted)
Farbe
white to light brown
Wasserlöslichkeit
H2O: 15mg/mL, clear
InChIKey
UKBGBACORPRCGG-UHFFFAOYSA-N
SMILES
C1(C(NCCCNC2C(C3CC3)=CN=C(NC3=CC=CC(CN4CCOCC4)=C3)N=2)=O)CCC1

Sicherheit

WGK Germany  3

N-[3-[[5-Cyclopropyl-2-[[3-(4-morpholinylmethyl)phenyl]amino]-4-pyrimidinyl]amino]propyl]cyclobutanecarboxamide Chemische Eigenschaften,Einsatz,Produktion Methoden

Verwenden

MRT67307 hydrochloride has been used to study its effect on LPS (lipopolysaccharide) -induced lysosome tubulation.

Biochem/physiol Actions

MRT67307 is an amino-pyrimidine derivative and has an IC50 value of 19. It is known to induce TLR (toll like receptor) mediated anti inflammatory cytokine generation. Also, MRT67307 prevents the secretion of cytokines associated with proinflammation.

N-[3-[[5-Cyclopropyl-2-[[3-(4-morpholinylmethyl)phenyl]amino]-4-pyrimidinyl]amino]propyl]cyclobutanecarboxamide Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

N-[3-[[5-Cyclopropyl-2-[[3-(4-morpholinylmethyl)phenyl]amino]-4-pyrimidinyl]amino]propyl]cyclobutanecarboxamide Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 114)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795
ivan@atkchemical.com China 33024 60
Shandong chuangyingchemical Co., Ltd. 		18853181302
sale@chuangyingchem.com CHINA 5906 58
BOC Sciences 		+1-631-485-4226
inquiry@bocsci.com United States 19552 58
CONIER CHEM AND PHARMA LIMITED 		+8618523575427
 sales@conier.com China 49975 58
TargetMol Chemicals Inc. 		+1-781-999-5354; +17819995354
 marketing@targetmol.com United States 32435 58
HANGZHOU CLAP TECHNOLOGY CO.,LTD 		86-571-88216897,88216896 13588875226
 sales@hzclap.com CHINA 6312 58
InvivoChem 		+1-708-310-1919 +1-13798911105
 sales@invivochem.cn United States 6391 58
TargetMol Chemicals Inc. 		+1-781-999-5354;
support@targetmol.com United States 39035 58
GIHI CHEMICALS CO.,LIMITED 		+8618058761490
 info@gihichemicals.com China 49936 58
Henan Fengda Chemical Co., Ltd 		+86-371-86557731 +86-13613820652
 info@fdachem.com China 20134 58
  • MRT67307
  • MRT67307 hydrochloride
  • N-[3-[[5-Cyclopropyl-2-[[3-(4-morpholinylmethyl)phenyl]amino]-4-pyrimidinyl]amino]propyl]-cyclobutanecarboxamide hydrochloride
  • MRT68921
  • N-[3-[[5-Cyclopropyl-2-[[3-(4-morpholinylmethyl)phenyl]amino]-4-pyrimidinyl]amino]propyl]cyclobutanecarboxamide
  • MRT67307 (free base)
  • IKKε/TBK1 Inhibitor II, MRT67307 - CAS 1190378-57-4 - Calbiochem
  • MRT67307 HCl
  • CS-2840
  • Cyclobutanecarboxamide, N-[3-[[5-cyclopropyl-2-[[3-(4-morpholinylmethyl)phenyl]amino]-4-pyrimidinyl]amino]propyl]-
  • MRT67307 HCl(free-base)
  • MRT67307, 10 mM in DMSO
  • IKKε/TBK1 Inhibitor II, MRT67307
  • MRT67307 (MRT 67307
  • 1190378-57-4
  • C26H36N6O2xHCl
  • NF-kB
  • API
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