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TYRPHOSTIN B7

TYRPHOSTIN B7 Struktur
134036-53-6
CAS-Nr.
134036-53-6
Englisch Name:
TYRPHOSTIN B7
Synonyma:
AG 370;TYRPHOSTIN B7;TYRPHOSTIN AG 370;TYROPHOSTIN AG 370;2-AMINO-4-(1H-INDOL-5-YL)-1,1,3-TRICYANOBUTA-1,3-DIENE;2-AMINO-4-(1H-INDO-5'-YL)-1,1,3-TRICYANOBUTA-1,3-DIENE;3-AMINO-4-(1H-INDOL-5-YLMETHYLENE)-2-PENTENETRICARBONITRILE;2-Pentenetricarbonitrile, 3-amino-4-(1H-indol-5-ylmethylene)-;2-Amino-4-(1H-indo-5μ-yl)-1,1,3-tricyanobuta-1,3-diene, Tyrphostin B7
CBNumber:
CB2288901
Summenformel:
C15H9N5
Molgewicht:
259.27
MOL-Datei:
134036-53-6.mol
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TYRPHOSTIN B7 Eigenschaften

Siedepunkt:
714.1±60.0 °C(Predicted)
Dichte
1.396±0.06 g/cm3(Predicted)
storage temp. 
−20°C
Löslichkeit
DMSO: soluble
pka
15.95±0.30(Predicted)
Aggregatzustand
Yellow solid.

Sicherheit

S-Sätze: 22-24/25
WGK Germany  3

TYRPHOSTIN B7 Chemische Eigenschaften,Einsatz,Produktion Methoden

S-Sätze Betriebsanweisung:

S22:Staub nicht einatmen.
S24/25:Berührung mit den Augen und der Haut vermeiden.

Beschreibung

Protein tyrosine kinase (PTK) inhibitors are potential antiproliferative agents for diseases caused by the hyperactivity of PTKs. Tyrphostins are a class of antiproliferative compounds which selectively inhibit PTKs of key growth factors such as epidermal growth factor (EGF) or platelet-derived growth factor (PDGF) by blocking the phosphorylation of specific tyrosine residues. AG-370 is a selective inhibitor of PDGF receptor kinase with an IC50 value of 20 μM in human bone marrow fibroblasts. It displays comparatively weak inhibition of the EGF receptor (IC50 = 820 μM).

TYRPHOSTIN B7 Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

TYRPHOSTIN B7 Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 36)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Aladdin Scientific 		+1-833-552-7181
sales@aladdinsci.com United States 52927 58
3B Pharmachem (Wuhan) International Co.,Ltd. 821-50328103-801 18930552037
 3bsc@sina.com China 15848 69
Spectrum Chemical Manufacturing Corp. 021-021-021-67601398-809-809-809 15221380277
 marketing_china@spectrumchemical.com China 9664 60
BOC Sciences 16314854226
 info@bocsci.com United States 9926 65
Shanghai EFE Biological Technology Co., Ltd. 021-65675885 18964387627
 info@efebio.com China 9709 58
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 18818260767
 sales@chemegen.com China 11289 58
MedBioPharmaceutical Technology Inc 021-69568360 18916172912
 order@med-bio.cn China 8141 58
TargetMol Chemicals Inc. 4008200310
 marketing@tsbiochem.com China 24131 58
ApexBio Technology --
 sales@apexbt.com United States 6254 58

134036-53-6()Verwandte Suche:

[(4-Hydroxyphenyl)methylen]malononitril 3-Aminoprop-1-en-1,1,3-tricarbonitril 3-Butennitril
  • AG 370
  • 2-Amino-4-(1H-indo-5μ-yl)-1,1,3-tricyanobuta-1,3-diene, Tyrphostin B7
  • TYROPHOSTIN AG 370
  • TYRPHOSTIN B7
  • TYRPHOSTIN AG 370
  • 3-AMINO-4-(1H-INDOL-5-YLMETHYLENE)-2-PENTENETRICARBONITRILE
  • 2-AMINO-4-(1H-INDO-5'-YL)-1,1,3-TRICYANOBUTA-1,3-DIENE
  • 2-AMINO-4-(1H-INDOL-5-YL)-1,1,3-TRICYANOBUTA-1,3-DIENE
  • 2-Pentenetricarbonitrile, 3-amino-4-(1H-indol-5-ylmethylene)-
  • 134036-53-6
  • Platelet Derived Growth Factor Receptor (PDGFR)
  • Receptor Tyrosine Kinase Inhibitors
  • Kinase/Phosphatase Biology
  • Cell Signaling and Neuroscience
  • Cell Biology
  • BioChemical
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