Lapatinib ditosylate
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- CAS-Nr.
- 388082-78-8
- Englisch Name:
- Lapatinib ditosylate
- Synonyma:
- Lapatinib ditosylate Monohydrate;Lapatinib tosilate;Lapatinib ditosylate hydrate;Lapatinb;GW2016 ditosylate;GW-572016;GW572016;lapatinib(GW572016);Lapatinib Ditosilate;Lapatinib ditosylate;xyene sulfonate lapatinib
- CBNumber:
- CB2966227
- Summenformel:
- C41H40ClFN4O11S3
- Molgewicht:
- 925.46
- MOL-Datei:
- 388082-78-8.mol
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Lapatinib ditosylate Eigenschaften
- Schmelzpunkt:
- >200oC (dec.)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- Löslichkeit
- DMSO (Slightly), Methanol (Slightly)
- Aggregatzustand
- Solid
- Farbe
- Yellow
- CAS Datenbank
- 388082-78-8(CAS DataBase Reference)
Sicherheit
- Risiko- und Sicherheitserklärung
- Gefahreninformationscode (GHS)
| Bildanzeige (GHS) |
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| Alarmwort |
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| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H413 |
Kann für Wasserorganismen schädlich sein, mit langfristiger Wirkung. |
Langfristig (chronisch) gewässergefährdend |
Kategorie 4 |
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Lapatinib ditosylate Chemische Eigenschaften,Einsatz,Produktion Methoden
Verwenden
Lapatinib ditosylate monohydrate is a form of Lapatinib I, an orally active drug for breast cancer as a dual EGFR and erbB-?2 inhibitor.
Allgemeine Beschreibung
Lapatinib is available in 250-mg tablets for oral administrationand is used in combination with cabecitabine in thetreatment of breast cancer for those patients that over expressthe type 2 EGF-R and who have previously receivedtaxane, anthracycline, and trastuzumab therapy. The type 2EGF-R is one subtype of this receptor and is also known asHER2 or ErbB-2. The agent is a receptor TK inhibitor targetingthe ErbB-1 and ErbB-2 subtypes. Binding occurs atthe ATP-binding site and thereby prevents phosphorylationand the subsequent activation of other kinase enzymes.ErbB-1 overexpression occurs in approximately27% to 30% of breast cancers, while ErbB-2 is over expressedin 20% to 25% of cases.The agent has demonstratedIC50 values of ＜0.2μM against ErbB-1 and 2 fromseveral different cancer cell lines and dissociates slowly(t
1/2＝300 min) from these receptor TKs.The drug isboth a substrate and an inhibitor of the efflux transportersPgp and BCRP. It is also an inhibitor of the hepatic uptaketransporter OATP1B1, which is an organic anion transporter.The absorption of lapatinib is incomplete andvariable after oral administration. The agent is extensivelymetabolized by CYP3A4 and CYP3A5, with minor contributionsfrom CYP2C19 and CYP2C8. Lapatinib inhibitsCYP3A and CYP2C8 at clinically relevant concentrations.The agent is highly (99%) protein bound and eliminatedprimarily in the feces. The half-life of the agent increaseupon repeated dosing, taking 6 days to reach steady statethat gives an effective half-life of 24 hours. The most commonlyseen adverse effects of lapatinib therapy are skinrash and diarrhea. Skin rash is commonly seen with manyof the other TK inhibitors and agents that target ErbB-1.Lapatinib-induced diarrhea is usually mild to moderate.There have been reports of decreases in left ventricularejection fraction associated with the agent, although thisappears to occur only rarely and is reversible upon discontinuationof therapy.
Lapatinib ditosylate Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Lapatinib ditosylate Anbieter Lieferant Produzent Hersteller Vertrieb Händler.
Global( 341)Lieferanten
388082-78-8()Verwandte Suche:
- Lapatinib ditosylate
- benzenesulfonic acid: N-[3-chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6 -[5-[(2-methylsulfonylethylamino)methyl]-2-furyl]quinazolin-4-amine: h ydrate
- N-(3-Chloro-4-((3-fluorophenyl)methoxy)phenyl)-6-(5-(((2-(methylsulfonyl)ethyl)amino)methyl)-2-furanyl)-4-quinazolinamine bis(4-methylbenzenesulfonate)
- Lapatinib Ditosilate
- Lapatinib, Tykerb, GW572016
- Lapatinib Ditosylate (GW-572016)
- lapatinib(GW572016)
- bis(N-(3-chloro-4-(3-fluorobenzyloxy)phenyl)-6-(5-((2-(Methylsulfonyl)ethylaMino)Methyl)furan-2-yl)quinazolin-4-aMine) tetrakis(4-Methylbenzenesulfonate) hydrate
- Lapatinb
- 4-QuinazolinaMine, N-[3-chloro-4-[(3-fluorophenyl)Methoxy]phenyl]-6-[5-[[[2-(Methylsulfonyl)ethyl]aMino]Methyl]-2-furanyl]-, bis(4-Methylbenzenesulfonate), Monohydrate (9CI)
- N-(3-Chloro-4-((3-fluorophenyl)methoxy)phenyl)-6-(5-(((2-(methylsulfonyl)ethyl)amino)methyl)-2-furanyl)-4-quinazolinamine bis(4-methylbenzenesulfonate) monohydrate
- 4-QuinazolinaMine, N-[3-chloro-4-[(3-fluorophenyl)Methoxy]phenyl]-6-[5-[[[2-(Methylsulfonyl)ethyl]aMino]Methyl]-2-furanyl]-, bis(4-Methylbenzenesulfonate), Monohydrate
- xyene sulfonate lapatinib
- (N-(3-chloro-4-(3-fluorobenzyloxy)phenyl)-6-(5-((2-(Methylsulfonyl)ethylaMino)Methyl)furan-2-yl)quinazolin-4-aMine)bis(4-Methylbenzenesulfonate) hydrate
- Lapatinib ditosylate N-(3-Chloro-4-((3-fluorophenyl)methoxy)phenyl)-6-(5-(((2-(methylsulfonyl)ethyl)amino)methyl)-2-furanyl)-4-quinazolinamine bis(4-methylbenzenesulfonate)
- N-(3-Chloro-4-(3-fluorobenzyloxy)phenyl)-6-(5-((2-(methylsulfonyl)ethylamino)methyl)furan-2-yl)-quinazolin-4-ylamine ditosylate hydrate
- Rapatinib bis - toluene sulfonate
- GW-572016;GW572016
- Lapatinib xylene sulfonate
- N-[3-Chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6-[5-[[[2-(methylsulfonyl)ethyl]amino]methyl]-2-furanyl]-4-quinazolinamine, 4-methylbenzenesulfonate, hydrate (1:2:1)
- Lapatinib Ditosylate MonohydrateI
- Lapatinib ditosylate hydrat
- Lapatinib ditoluenesulfonate monohydrate
- Lapatinib tosilate hydrate
- Lapatinib ditosylate ISO 9001：2015 REACH
- Lapatinib D4 DitosylateQ: What is
Lapatinib D4 Ditosylate Q: What is the CAS Number of
Lapatinib D4 Ditosylate
- Lapatinib tosilate
- Lapatinib ditosylate Monohydrate
- Lapatinib ditosylate hydrate
- Lapatinib p-toluenesulfonate monohydrate
- GW2016 ditosylate
- 388082-78-8
- 388083-78-8
- 388082-78-9
- C29H26ClFN4O4S2C7H8O3
- C29H26ClFN4O4S2C7H8O3S
- C41H40ClFN4O11S3
- C29H26ClFN4O4S2C74H8O3SH2O
- C29H26ClFN4O4S2C7H8O3SH2O
- C43H44ClFN4O11S3
- 2C7H8O3SC29H26ClFN4O4S
- anti-neoplastic
- Inhibitors
- Anti-cancer&immunity
- Lapatinib
- API
- 388082-78-8
